373例乙型肝炎患者HBV-DNA定量与乙型肝炎病毒核心抗原及肝脏酶学指标的相关性分析(1)
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[摘要] 目的 探讨HBV-DNA定量和乙型肝炎病毒核心抗原在诊断乙型肝炎和评价病情中的意义。 方法 收集373例乙型肝炎患者的HBV-DNA定量、HBeAg与丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、谷氨酰转移酶(GGT)等实验室诊断指标，进行相关性分析。 结果 (1)HBV-DNA定量与HBeAg具有相关性(P < 0.01)。(2)HBV-DNA定量与ALT、AST、GGT结果具有相关性(P < 0.01)。(3)HBeAg与ALT、AST、GGT结果无相关性(P > 0.05)。 结论 (1)HBeAg一定程度上反映了病毒在体内的复制情况，但HBV-DNA定量是评价体内病毒复制更直接的指标。(2)HBV-DNA定量结果与肝功能受损情况相关，高病毒载量是肝功能受损的危险因素。
[关键词] 乙型肝炎；实验室诊断；HBV-DNA；乙型肝炎病毒核心抗原；丙氨酸氨基转移酶；天冬氨酸氨基转移酶；谷氨酰转移酶
[中图分类号] R512.6+2 [文献标识码] A [文章编号] 1674-4721(2012)07(a)-0110-03
Correlation analysis of 373 cases of hepatitis B patients with HBV-DNA quantitative, HBeAg and liver enzymatic indicators
ZHANG Qian1 FANG Chaoping
1.Department of Sea Medical, Second Military Medical University, Shanghai 200433, China; 2.Laboratory Diagnosis Division, Second Military Medical University Changhai Hospital, Shanghai 200433, China
[Abstract] Objective To explore the significance of quantitative HBV-DNA and HBeAg in the diagnosis of hepatitis B and in the evaluation of disease. Methods Three hundred and seventy-three cases of hepatitis B patients with HBV-DNA quantitative, HBeAg, ALT, AST and GGT laboratory diagnostic indicators were collected, and the correlation analysis was conducted. Results (1)There was correlation between HBV-DNA quantitative and HBeAg (P < 0.01). (2)There was correlation between HBV-DNA quantitative and ALT, AST, GGT (P < 0.01). (3)There was no correlation between HBeAg and ALT, AST, GGT (P > 0.05). Conclusion (1)HBeAg reflects the replication of the virus in the body to a certain extent. However, HBV-DNA quantitative is a more direct indicator to evaluate the viral replication in vivo ......
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