马来酸依那普利联合前列地尔治疗糖尿病肾病的临床疗效观察(1)
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[摘要] 目的 观察马来酸依那普利联合前列地尔治疗糖尿病肾病患者的临床疗效。 方法 将68例糖尿病肾病患者随机分为观察组与对照组，每组各34例，对照组在常规糖尿病治疗基础上，给予马来酸依那普利10 mg，口服，1次/d；观察组在对照组治疗基础上，加用前列地尔注射液10 μg，静脉滴注，1次/d；两组疗程均为4周。 结果 治疗结束后，观察组尿清蛋白排泄率(UAER)、血清肌酐(Scr)含量均较治疗前显著下降(P < 0.05)；观察组临床总有效率为91.18%，显著高于对照组的61.76%(P < 0.05)。 结论 马来酸依那普利联合前列地尔治疗糖尿病肾病的疗效显著，值得推广使用。
[关键词] 依那普利；前列地尔；糖尿病肾病；疗效
[中图分类号] R587.2 [文献标识码] A [文章编号] 1674-4721(2012)07(b)-0072-02
Clinical efficacy of maleate enalapril and alprostadil in patients with diabetic nephropathy
Aizemujiang·tuersun
Shache County People's Hospital of Kashi in Xinjiang Uygur Autonomous Region, Shache 844700, China
[Abstract] Objective To observe the clinical efficacy of maleate enalapril and alprostadil in patients with diabetic nephropathy (DN) and dyslipidemia. Methods Sixty-eight cases with DN patients were randomly divided into observation group (n = 34) and control group (n = 34). The two groups were treated with conventional treatment, and on the basis of this, control group was treated with maleate enalapril, the observation group was treated with maleate enalapril and alprostadil for four weeks. Results After the treatment, the levels of UAER and Scr were significantly lower than those before treatment in the observation group (P < 0.05). The clinical total effective rate was 91.18% in the observation group, which was significantly higher than that (61.76%) of the control group (P < 0.05). Conclusion The clinical efficacy of maleate enalapril and alprostadil for the treatment of DN is significant, it is worthy of being recommended in the clinic.
[Key words] Maleate enalapril; Alprostadil; Diabetic nephropathy; Efficacy ......
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