应用64排CT评价两种剂量阿托伐他汀对急性冠脉综合征PCI术后冠状动脉斑块的影响(1)
[摘要] 目的 通过64排CT观察两种不同剂量阿托伐他汀对血脂、超敏C反应蛋白(Hs-CRP)和冠状动脉斑块的影响。 方法 48例急性冠脉综合征(ACS)冠状动脉介入治疗(PCI)术后1个月内进行64排CT检查，随机分为强化他汀组(阿托伐他汀40 mg/d+常规用药)和常规他汀组(阿托伐他汀20 mg/d+常规用药)，入组时分别检查TC、TG、LDL-C 、HDL-C、Hs-CRP和冠状动脉斑块类型及面积，随访12个月后再复查以上指标。 结果 治疗12个月后，两组TC、LDL-C、TG和Hs-CRP均较治疗前下降(P<0.05)；HDL-C均较前升高(P<0.05)；强化他汀组治疗后脂质斑块和纤维斑块面积缩小(P<0.05)；常规他汀治疗组斑块面积无明显改变(P>0.05)；两组脂质斑块和纤维斑块CT值均较前增加，强化他汀组更明显(P<0.05)；两组钙化斑块面积和CT值改变差异无统计学意义(P>0.05)。 结论 应用64排CT可以定性、定量检查冠状动脉斑块情况；阿托伐他汀强化治疗可以使冠状动脉斑块更稳定，甚至缩小、逆转非钙化斑块。
, 百拇医药
[关键词] 64排螺旋CT；冠状动脉斑块；阿托伐他汀
[中图分类号] R543.3 [文献标识码] A [文章编号] 1674-4721(2013)07(a)-0026-03
Influence evaluation of two doses of Atorvastatin for coronary plaque of acute coronary syndrome after PCI by applying 64-slice CT
MA Wen-xue PENG Jian-feng JIANG Zhi-gao GU Yu-yan BI Jian-cheng XV Zhi-qi
Department of Cardiovascular Medicine， People's Hospital of Huadu District in Guangzhou City of Guangdong Province， Guangzhou 510800， China
, 百拇医药
[Abstract] Objective To observe the impact of two different doses of Atorvastatin on serum lipids， high-sensitivity C-reactive protein (Hs-CRP) and coronary plaque by 64-slice CT. Methods Forty eight patients with acute coronary syndrome (ACS)， who were detected by 64-slice CT within one month after percutaneous coronary intervention (PCI)， were randomly assigned into intensive statins group (Atorvastatin 40 mg/d + regular medication) and convention statins group (Atorvastatin 20 mg/d + regular medication) with TC， TG， LDL-C， HDL-C， hs-CRP， coronary plaque type and size examined simultaneously. The above indicators were reviewed after 12 months of follow up. Results After treatment of 12 months， the levels of TC， TG， LDL-C， and hs-CRP in both groups were lowered compare with the levels before treatment (P<0.05)； the levels of HDL-C in both groups were increased (P<0.05)； the lipid and fibrous plaque area of patients in intensive statins group were minified after treatment， compared with the previous data (P<0.05)； the plaque area of patients in invention statins group had no significant change (P>0.05)； the CT values of lipid and fibrous plaque area of patients in both groups were increased compared to the previous data with more significant change of intensive statins group (P<0.05)； there was no statistical significance of changes in calcified plaque area and CT values of both groups (P>0.05). Conclusion Application of 64-slice CT can qualitatively and quantitatively detect changes of coronary plaque； intensive treatment of Atorvastatin can make the coronary plaque more stable， or even minify， and reverse noncalcified plaque., 百拇医药
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马文学 彭剑峰 江志羔 古玉燕 毕健成 徐志奇 广州市花都区人民医院心血管内科;
【摘要】目的通过64排CT观察两种不同剂量阿托伐他汀对血脂、超敏C反应蛋白(Hs-CRP)和冠状动脉斑块的影响。方法 48例急性冠脉综合征(ACS)冠状动脉介入治疗(PCI)术后1个月内进行64排CT检查,随机分为强化他汀组(阿托伐他汀40 mg/d+常规用药)和常规他汀组(阿托伐他汀20 mg/d+常规用药),入组时分别检查TC、TG、LDL-C、HDL-C、Hs-CRP和冠状动脉斑块类型及面积,随访12个月后再复查以上指标。结果治疗12个月后,两组TC、LDL-C、TG和Hs-CRP均较治疗前下降(P0.05);HDL-C均较前升高(P0.05);强化他汀组治疗后脂质斑块和纤维斑块面积缩小(P0.05);常规他汀治疗组斑块面积无明显改变(P0.05);两组脂质斑块和纤维斑块CT值均较前增加,强化他汀组更明显(P0.05);两组钙化斑块面积和CT值改变差异无统计学意义(P0.05)。结论应用64排CT可以定性、定量检查冠状动脉斑块情况;阿托伐他汀强化治疗可以使冠状动脉斑块更稳定,甚至缩小、逆转非钙化斑块。
【关键词】 排螺旋CT 冠状动脉斑块 阿托伐他汀
【分类号】R541.4
冠状动脉粥样硬化性心脏病是常见病、多发病,尤其急性冠脉综合征严重影响危害人民群众的身体健康。冠状动脉介入治疗(percutaneous coronary intervention,PCI)能有效治疗冠心病,特别是急性冠脉综合征发作期间可有效开通罪犯血管,有效改善患者的预后,但冠状动脉PCI术后新发冠(马文学 彭剑峰 江志羔 古玉燕 毕健成 )
, 百拇医药
[关键词] 64排螺旋CT；冠状动脉斑块；阿托伐他汀
[中图分类号] R543.3 [文献标识码] A [文章编号] 1674-4721(2013)07(a)-0026-03
Influence evaluation of two doses of Atorvastatin for coronary plaque of acute coronary syndrome after PCI by applying 64-slice CT
MA Wen-xue PENG Jian-feng JIANG Zhi-gao GU Yu-yan BI Jian-cheng XV Zhi-qi
Department of Cardiovascular Medicine， People's Hospital of Huadu District in Guangzhou City of Guangdong Province， Guangzhou 510800， China
, 百拇医药
[Abstract] Objective To observe the impact of two different doses of Atorvastatin on serum lipids， high-sensitivity C-reactive protein (Hs-CRP) and coronary plaque by 64-slice CT. Methods Forty eight patients with acute coronary syndrome (ACS)， who were detected by 64-slice CT within one month after percutaneous coronary intervention (PCI)， were randomly assigned into intensive statins group (Atorvastatin 40 mg/d + regular medication) and convention statins group (Atorvastatin 20 mg/d + regular medication) with TC， TG， LDL-C， HDL-C， hs-CRP， coronary plaque type and size examined simultaneously. The above indicators were reviewed after 12 months of follow up. Results After treatment of 12 months， the levels of TC， TG， LDL-C， and hs-CRP in both groups were lowered compare with the levels before treatment (P<0.05)； the levels of HDL-C in both groups were increased (P<0.05)； the lipid and fibrous plaque area of patients in intensive statins group were minified after treatment， compared with the previous data (P<0.05)； the plaque area of patients in invention statins group had no significant change (P>0.05)； the CT values of lipid and fibrous plaque area of patients in both groups were increased compared to the previous data with more significant change of intensive statins group (P<0.05)； there was no statistical significance of changes in calcified plaque area and CT values of both groups (P>0.05). Conclusion Application of 64-slice CT can qualitatively and quantitatively detect changes of coronary plaque； intensive treatment of Atorvastatin can make the coronary plaque more stable， or even minify， and reverse noncalcified plaque., 百拇医药
------
马文学 彭剑峰 江志羔 古玉燕 毕健成 徐志奇 广州市花都区人民医院心血管内科;
【摘要】目的通过64排CT观察两种不同剂量阿托伐他汀对血脂、超敏C反应蛋白(Hs-CRP)和冠状动脉斑块的影响。方法 48例急性冠脉综合征(ACS)冠状动脉介入治疗(PCI)术后1个月内进行64排CT检查,随机分为强化他汀组(阿托伐他汀40 mg/d+常规用药)和常规他汀组(阿托伐他汀20 mg/d+常规用药),入组时分别检查TC、TG、LDL-C、HDL-C、Hs-CRP和冠状动脉斑块类型及面积,随访12个月后再复查以上指标。结果治疗12个月后,两组TC、LDL-C、TG和Hs-CRP均较治疗前下降(P0.05);HDL-C均较前升高(P0.05);强化他汀组治疗后脂质斑块和纤维斑块面积缩小(P0.05);常规他汀治疗组斑块面积无明显改变(P0.05);两组脂质斑块和纤维斑块CT值均较前增加,强化他汀组更明显(P0.05);两组钙化斑块面积和CT值改变差异无统计学意义(P0.05)。结论应用64排CT可以定性、定量检查冠状动脉斑块情况;阿托伐他汀强化治疗可以使冠状动脉斑块更稳定,甚至缩小、逆转非钙化斑块。
【关键词】 排螺旋CT 冠状动脉斑块 阿托伐他汀
【分类号】R541.4
冠状动脉粥样硬化性心脏病是常见病、多发病,尤其急性冠脉综合征严重影响危害人民群众的身体健康。冠状动脉介入治疗(percutaneous coronary intervention,PCI)能有效治疗冠心病,特别是急性冠脉综合征发作期间可有效开通罪犯血管,有效改善患者的预后,但冠状动脉PCI术后新发冠(马文学 彭剑峰 江志羔 古玉燕 毕健成 )