恩替卡韦治疗慢性重型乙型肝炎的临床效果及安全性观察
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[摘要] 目的 探讨恩替卡韦治疗慢性重型乙型肝炎的临床效果。 方法 选择本院2013年1月～2014年1月收治的慢性重型乙型肝炎患者96例，将其随机分为观察组和对照组，每组48例，均接受基础支持治疗，对照组加用拉米夫定治疗，观察组加用恩替卡韦治疗，对比两组的临床效果及治疗前后肝功能和血清HBV DNA改善情况。 结果 观察组总有效率为97.92%，高于对照组的83.33%(P<0.05)；观察组治疗后肝功能和血清HBV DNA明显优于对照组(P<0.05)。 结论 恩替卡韦治疗慢性重型乙型肝炎的临床效果显著，能改善患者的生活质量，值得临床推广应用。
[关键词] 慢性重型乙型肝炎；恩替卡韦；临床效果
[中图分类号] R512.6+2[文献标识码] A[文章编号] 1674-4721(2014)04(c)-0097-02
Clinical efficacy and security observation of entecavir in treatment of chronic severe hepatitis B
LIU Xiao-bo ZHU Hong
People′s Hospital of Jishui County in Jiangxi Province,Jishui 331600,China
[Abstract] Objective To investigate the clinical effect of entecavir in the treatment of chronic severe hepatitis B.Methods 96 cases of patients with chronic severe hepatitis B in our hospital from January 2013 to January 2014 were selected,and were randomly divided into observation group and control group,48 cases in each group.All patients were treated with basic treatment,the control group were treated with lamivudine,observation group were treated with entecavir ......
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