枯草杆菌二联活菌肠溶胶囊联合地衣芽胞杆菌活菌胶囊治疗老年抗生素相关性腹泻的效果分析(1)
[摘要] 目的 探讨枯草杆菌二联活菌肠溶胶囊联合地衣芽胞杆菌活菌胶囊对老年抗生素相关性腹泻的临床疗效。 方法 收集2013年2月～2014年2月本院老年抗生素相关性腹泻患者120例，根据随机数字表法分为枯草杆菌二联活菌肠溶胶囊组、地衣芽胞杆菌活菌胶囊组、枯草杆菌二联活菌肠溶胶囊和地衣芽胞杆菌活菌胶囊联合组各40例。比较3组的治疗效果。 结果 联合组1个月内的腹泻治愈率高于枯草杆菌二联活菌肠溶胶囊组及地衣芽胞杆菌活菌胶囊组，差异有统计学意义(χ2=8.26，P=0.02)。联合组未愈患者1个月内的腹泻次数明显低于枯草杆菌二联活菌肠溶胶囊组及地衣芽胞杆菌活菌胶囊组，差异有统计学意义(F=91.03，P=0.00)。 结论 枯草杆菌二联活菌肠溶胶囊以及地衣芽胞杆菌活菌胶囊均为益生菌类药物，对治疗老年人抗生素相关性腹泻有一定的疗效，但是枯草杆菌二联活菌肠溶胶囊联合地衣芽胞杆菌活菌胶囊对老年抗生素相关性腹泻的疗效更显著，对于临床治疗有一定的协助作用。
[关键词] 抗生素相关性腹泻；枯草杆菌二联活菌肠溶胶囊；地衣芽胞杆菌活菌胶囊
[中图分类号] R975 [文献标识码] A [文章编号] 1674-4721(2015)01(b)-0103-03
Effect analysis of Bacillus subtilis two (Live) enteric-coated capsules combined with Bacillus licheniformis capsule in the treatment of antibiotic associated diarrhea
YUAN Hong-wei
Department of Pharmacy，Affiliated Hospital of Yanbian University，Jilin Province，Yanji 133000，China
[Abstract] Objective To explore the clinical effect of Bacillus subtilis two (Live) enteric-coated capsules combined with Bacillus licheniformis capsule in the treatment of antibiotic associated diarrhea. Methods 120 patients with antibiotic associated diarrhea in our hospital from February 2013 to February 2014 were selected，and were divided into three groups based on random number table，Bacillus subtilis two (Live) enteric-coated capsules group，Bacillus licheniformis capsule group，and joint application of Bacillus subtilis two (Live) enteric-coated capsules and Bacillus licheniformis capsule group.The therapeutic effects among three groups were compared. Results The cure rate of joint application of Bacillus subtilis two (Live) enteric-coated capsules and Bacillus licheniformis capsule group was higher than that of Bacillus subtilis two (Live) enteric-coated capsules group and Bacillus licheniformis capsule group，the difference was significant (χ2=8.26，P=0.02).The number of diarrhea in healed patients of joint application of Bacillus subtilis two (Live) enteric-coated capsules and Bacillus licheniformis capsule group was less than that of Bacillus subtilis two (Live) enteric-coated capsules group and Bacillus licheniformis capsule group，the difference was significant (F=91.03，P=0.00). Conclusion Both Bacillus subtilis two (Live) enteric-coated capsules and Bacillus licheniformis capsule are classified into probiotics，and have some effect on treating senile associated diarrhea caused by antibiotics.Joint application of the two drugs displays remarkable effect on treating antibiotic associated diarrhea，and plays a certain assistant role in clinical treatment. (袁宏伟)
[关键词] 抗生素相关性腹泻；枯草杆菌二联活菌肠溶胶囊；地衣芽胞杆菌活菌胶囊
[中图分类号] R975 [文献标识码] A [文章编号] 1674-4721(2015)01(b)-0103-03
Effect analysis of Bacillus subtilis two (Live) enteric-coated capsules combined with Bacillus licheniformis capsule in the treatment of antibiotic associated diarrhea
YUAN Hong-wei
Department of Pharmacy，Affiliated Hospital of Yanbian University，Jilin Province，Yanji 133000，China
[Abstract] Objective To explore the clinical effect of Bacillus subtilis two (Live) enteric-coated capsules combined with Bacillus licheniformis capsule in the treatment of antibiotic associated diarrhea. Methods 120 patients with antibiotic associated diarrhea in our hospital from February 2013 to February 2014 were selected，and were divided into three groups based on random number table，Bacillus subtilis two (Live) enteric-coated capsules group，Bacillus licheniformis capsule group，and joint application of Bacillus subtilis two (Live) enteric-coated capsules and Bacillus licheniformis capsule group.The therapeutic effects among three groups were compared. Results The cure rate of joint application of Bacillus subtilis two (Live) enteric-coated capsules and Bacillus licheniformis capsule group was higher than that of Bacillus subtilis two (Live) enteric-coated capsules group and Bacillus licheniformis capsule group，the difference was significant (χ2=8.26，P=0.02).The number of diarrhea in healed patients of joint application of Bacillus subtilis two (Live) enteric-coated capsules and Bacillus licheniformis capsule group was less than that of Bacillus subtilis two (Live) enteric-coated capsules group and Bacillus licheniformis capsule group，the difference was significant (F=91.03，P=0.00). Conclusion Both Bacillus subtilis two (Live) enteric-coated capsules and Bacillus licheniformis capsule are classified into probiotics，and have some effect on treating senile associated diarrhea caused by antibiotics.Joint application of the two drugs displays remarkable effect on treating antibiotic associated diarrhea，and plays a certain assistant role in clinical treatment. (袁宏伟)