阿德福韦酯联合异甘草酸镁治疗慢性乙型肝炎的近期效果观察(1)
[摘要] 目的 探讨阿德福韦酯联合异甘草酸镁治疗慢性乙型肝炎的近期效果。 方法 选择2013年1月～2014年1月来本院就诊的90例慢性乙型肝炎患者，随机分为对照组和实验组各45例，对照组给予常规阿德福韦酯治疗，实验组在对照组治疗的基础上加以异甘草酸镁治疗，治疗30周，评定两组的疗效。 结果 治疗前，两组患者的丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、白蛋白和球蛋白的比值(A/G)及总胆红素(TBiL)比较，差异无统计学意义(P>0.05)；治疗后，两组患者的ALT、AST、A/G及TBiL较治疗前降低，差异有统计学意义(P<0.05)；实验组患者的ALT、AST及TBiL均明显低于对照组，差异有统计学意义(P<0.05)，但A/G差异无统计学意义(P>0.05)。治疗后，两组血清HBV-DNA复制水平均明显下降，差异有统计学意义(P<0.05)，但实验组下降更加明显(P<0.05)，且血清HBV-DNA<1000 copies/ml的比例高于对照组，差异有统计学意义(P<0.05)。 结论 阿德福韦酯联合异甘草酸镁治疗慢性乙型肝炎的近期效果显著，值得临床推广应用。
[关键词] 阿德福韦酯；异甘草酸镁；乙型肝炎
[中图分类号] R512.6+2 [文献标识码] A [文章编号] 1674-4721(2015)02(a)-0077-03
The clinical effect observation of adefovir dipivoxil combined with magnesium isoglycyrrhizinate in treatment of hepatitis B
YAO Zhan WANG Li-ya FANG Gui-hua
Department of Infectious Diseases，Affiliated Hospital of Guangdong Medical College，Zhanjang 524001，China
[Abstract] Objective To study the effect of adefovir dipivoxil combined with magnesium isoglycyrrhizinate in treatment of hepatitis B. Methods 90 cases of patients with hepatitis B treated in our hospital from January 2013 to January 2014 were selected，and were randomly divided into control group and experiment group，45 cases in each group，control group were taken with adefovir dipivoxil，experiment group were added with magnesium isoglycyrrhizinate on the basis of control group，After 30 weeks treatment，the clinical effect of two groups was compared. Results Before treatment，alanine aminotransferase (ALT)，aspartate aminotransferase (AST)，albumin and globulin ratio (A/G) and total bilirubin (TBiL) of the two groups had no significant difference (P>0.05)；After treatment，ALT，AST，A/G and TBiL of the two groups decreased compared with before treatment，the difference was significant (P<0.05)；ALT，AST and TBiL of the experiment group was lower than that of control group，the difference was significant (P<0.05)，but A/G of the two groups had no significant difference (P>0.05).After treatment，the level of serum HBV-DNA replication in the two groups decreased compare with before treatment，the difference was significant (P<0.05)，and the experiment group decreased more than that of control group (P<0.05)；the ratio of serum HBV-DNA < 1000 copies/ml in the experimental group was higher than that in control group，the difference was significant (P<0.05). Conclusion Adefovir dipivoxil combined with magnesium isoglycyrrhizinate in treatment of hepatitis B has prefect clinical efficacy，and it is worthy of clinical promotion. (姚湛 王丽娅 方贵华)
[关键词] 阿德福韦酯；异甘草酸镁；乙型肝炎
[中图分类号] R512.6+2 [文献标识码] A [文章编号] 1674-4721(2015)02(a)-0077-03
The clinical effect observation of adefovir dipivoxil combined with magnesium isoglycyrrhizinate in treatment of hepatitis B
YAO Zhan WANG Li-ya FANG Gui-hua
Department of Infectious Diseases，Affiliated Hospital of Guangdong Medical College，Zhanjang 524001，China
[Abstract] Objective To study the effect of adefovir dipivoxil combined with magnesium isoglycyrrhizinate in treatment of hepatitis B. Methods 90 cases of patients with hepatitis B treated in our hospital from January 2013 to January 2014 were selected，and were randomly divided into control group and experiment group，45 cases in each group，control group were taken with adefovir dipivoxil，experiment group were added with magnesium isoglycyrrhizinate on the basis of control group，After 30 weeks treatment，the clinical effect of two groups was compared. Results Before treatment，alanine aminotransferase (ALT)，aspartate aminotransferase (AST)，albumin and globulin ratio (A/G) and total bilirubin (TBiL) of the two groups had no significant difference (P>0.05)；After treatment，ALT，AST，A/G and TBiL of the two groups decreased compared with before treatment，the difference was significant (P<0.05)；ALT，AST and TBiL of the experiment group was lower than that of control group，the difference was significant (P<0.05)，but A/G of the two groups had no significant difference (P>0.05).After treatment，the level of serum HBV-DNA replication in the two groups decreased compare with before treatment，the difference was significant (P<0.05)，and the experiment group decreased more than that of control group (P<0.05)；the ratio of serum HBV-DNA < 1000 copies/ml in the experimental group was higher than that in control group，the difference was significant (P<0.05). Conclusion Adefovir dipivoxil combined with magnesium isoglycyrrhizinate in treatment of hepatitis B has prefect clinical efficacy，and it is worthy of clinical promotion. (姚湛 王丽娅 方贵华)