氯吡格雷联合氟伐他汀治疗脑梗死的临床效果观察(1)
[摘要] 目的 观察氯吡格雷联合氟伐他汀治疗脑梗死的临床效果。 方法 选取本院2013年1月～2014年6月收入院的脑梗死患者61例，采取随机数字表法分为对照组(31例)和治疗组(30例)，对照组给予抗血小板、降血压、胰岛素控制血糖等常规治疗；治疗组在常规治疗的基础上加用氯吡格雷75 mg，1次/d口服，氟伐他汀40 mg，晚睡前口服。1周为1个疗程，治疗两个疗程。治疗后，比较治疗前后两组患者的C-反应蛋白、血脂变化情况及临床疗效。 结果 治疗后，治疗组的C-反应蛋白、TC及LDL-C水平均低于对照组，差异有统计学意义(P<0.05)；治疗组总有效率为93.33%，高于对照组的83.87%，差异有统计学意义(P<0.05)。 结论 氯吡格雷联合氟伐他汀治疗脑梗死能明显改善患者病情，效果显著，值得临床推广应用。
[关键词] 脑梗死；氯吡格雷；氟伐他汀
[中图分类号] R971 [文献标识码] A [文章编号] 1674-4721(2015)02(a)-0085-03
Clinical efficacy observation of clopidogrel combined with fluvastatin in treatment of cerebral infarction
LI Rui-bao
Department of Pharmacy，the Central Hospital of Jiangmen City in Guangdong Province，Jiangmen 529000，China
[Abstract] Objective To observe the clinical efficacy of clopidogrel combined with fluvastatin in treatment of cerebral infarction. Methods 61 cases of patients with cerebral infarction treated in our hospital from January 2013 to June 2014 were selected，and were randomly divided into control group (31 cases) and treatment group (30 cases).The control group were taken with antiplatelet，lowering blood pressure，insulin to control blood sugar and other conventional treatment，on the basis of conventional treatment，the treatment group were taken with clopidogrel 75 mg oral，once a day；fluvastatin 40 mg，before sleep，oral.One week as a course，two courses of treatment. C-reactive protein，blood lipid changes and clinical efficacy of the two groups was compared. Results After treatment，C-reactive protein，TC and LDL-C of treatment group was lower than that of control group，the difference was significant (P<0.05).The total effective rate of treatment group was 93.33%，higher than 83.87% of the control group，the difference was significant (P<0.05). Conclusion Clopidogrel combined with fluvastatin in treatment of cerebral infarction can significantly improve the patients′ condition，the efficacy is significant，and is worthy of clinical promotion.
[Key words] Cerebral infarction；Clopidogrel；Fluvastatin
脑梗死是由于脑动脉主干或皮质动脉支干动脉粥样硬化，致血管内皮斑块堆积增厚、管腔狭窄闭塞，使血管内血流动力学改变，并最终导致血栓栓塞脑动脉[1]，可引起局部脑组织血流灌溉减少或供血阻断，脑细胞及周围组织缺少血氧供应而发生坏死并产生局灶性神经系统症状。缺血性脑梗死是最常见的脑血管疾病，其高栓塞率、高致残率及较差的预后均给患者造成不可逆转的后遗症，严重危害患者的身体健康与生活质量。目前抗血栓疗法临床效果并不理想，为了得到理想疗效及较高的预后效果，对脑梗死患者尽早、正确地应用药物至关重要。临床研究发现，氯吡格雷能有效抑制血小板在血管内皮的聚集，氟伐他汀可很好地控制血脂、降低血黏稠度[2]。本研究通过观察用药前后C-反应蛋白水平、血脂改变情况及临床症状改善情况，探讨氯吡格雷及氟伐他汀对脑梗死患者的临床疗效。
1 资料与方法
1.1 一般资料
选取本院2013年1月～2014年6月收入院的脑梗死患者61例，采用随机数字表法分为治疗组和对照组。治疗组30例，其中男14例，女16例，平均年龄(53.6±8.5)岁；对照组31例，其中男15例，女16例，平均年龄(54.1±7.3)岁。两组患者的性别、年龄等一般资料差异无统计学意义(P>0.05)，具有可比性。 (李瑞宝)
[关键词] 脑梗死；氯吡格雷；氟伐他汀
[中图分类号] R971 [文献标识码] A [文章编号] 1674-4721(2015)02(a)-0085-03
Clinical efficacy observation of clopidogrel combined with fluvastatin in treatment of cerebral infarction
LI Rui-bao
Department of Pharmacy，the Central Hospital of Jiangmen City in Guangdong Province，Jiangmen 529000，China
[Abstract] Objective To observe the clinical efficacy of clopidogrel combined with fluvastatin in treatment of cerebral infarction. Methods 61 cases of patients with cerebral infarction treated in our hospital from January 2013 to June 2014 were selected，and were randomly divided into control group (31 cases) and treatment group (30 cases).The control group were taken with antiplatelet，lowering blood pressure，insulin to control blood sugar and other conventional treatment，on the basis of conventional treatment，the treatment group were taken with clopidogrel 75 mg oral，once a day；fluvastatin 40 mg，before sleep，oral.One week as a course，two courses of treatment. C-reactive protein，blood lipid changes and clinical efficacy of the two groups was compared. Results After treatment，C-reactive protein，TC and LDL-C of treatment group was lower than that of control group，the difference was significant (P<0.05).The total effective rate of treatment group was 93.33%，higher than 83.87% of the control group，the difference was significant (P<0.05). Conclusion Clopidogrel combined with fluvastatin in treatment of cerebral infarction can significantly improve the patients′ condition，the efficacy is significant，and is worthy of clinical promotion.
[Key words] Cerebral infarction；Clopidogrel；Fluvastatin
脑梗死是由于脑动脉主干或皮质动脉支干动脉粥样硬化，致血管内皮斑块堆积增厚、管腔狭窄闭塞，使血管内血流动力学改变，并最终导致血栓栓塞脑动脉[1]，可引起局部脑组织血流灌溉减少或供血阻断，脑细胞及周围组织缺少血氧供应而发生坏死并产生局灶性神经系统症状。缺血性脑梗死是最常见的脑血管疾病，其高栓塞率、高致残率及较差的预后均给患者造成不可逆转的后遗症，严重危害患者的身体健康与生活质量。目前抗血栓疗法临床效果并不理想，为了得到理想疗效及较高的预后效果，对脑梗死患者尽早、正确地应用药物至关重要。临床研究发现，氯吡格雷能有效抑制血小板在血管内皮的聚集，氟伐他汀可很好地控制血脂、降低血黏稠度[2]。本研究通过观察用药前后C-反应蛋白水平、血脂改变情况及临床症状改善情况，探讨氯吡格雷及氟伐他汀对脑梗死患者的临床疗效。
1 资料与方法
1.1 一般资料
选取本院2013年1月～2014年6月收入院的脑梗死患者61例，采用随机数字表法分为治疗组和对照组。治疗组30例，其中男14例，女16例，平均年龄(53.6±8.5)岁；对照组31例，其中男15例，女16例，平均年龄(54.1±7.3)岁。两组患者的性别、年龄等一般资料差异无统计学意义(P>0.05)，具有可比性。 (李瑞宝)