补肾填精活血方治疗骨质疏松症的效果及对β—胶原降解产物的影响(1)
[摘要] 目的 探讨补肾填精活血方治疗骨质疏松症(OP)的效果及对β-胶原降解产物的影响。 方法 选取132例OP患者作为研究对象，随机分为研究组与对照组。对照组采用维生素D、碳酸钙D3及骨化三醇胶丸治疗，研究组采用补肾填精活血方治疗，比较两组的治疗效果及β-胶原降解产物指标。 结果 研究组的总有效率为96.97%，显著高于对照组的81.81%(P<0.05)。研究组的β-胶原降解产物指标显著低于对照组及治疗前(P<0.05)。 结论 补肾填精活血方可以有效强化骨密度，改善临床症状，对β-胶原降解产物亦有显著的降解作用，值得临床推广应用。
[关键词] 补肾填精活血方；骨质疏松症；β-胶原降解产物
[中图分类号] R681 [文献标识码] A [文章编号] 1674-4721(2015)02(a)-0106-03
Effect of Bushen Tianjing Huoxue formula in the treatment of osteoporosis and influence on β-crosslaps degradation products
LIAO Kang-han LI De-yu ZHU Hui-jun LUO Xiao-guang TAN Ning
Department of Rheumatology of Traditional Chinese Medicine，Affiliated Nanshan Hospital of Guangdong Medical College，Shenzhen 518052，China
[Abstract] Objective To explore the effect of Bushen Tianjing Huoxue formula on patients with osteoporosis (OP) and influence on β-collagen degradation products. Methods 132 cases of OP were selected and randomly divided into the study group and the control group.The control group was treated with vitamin D，calcium carbonate D3 and calcitriol soft capsules，the study group was treated with Bushen Tianjing Huoxue formula.The total effective rate and the index of β-collagen degradation products in two groups was compared. Results The total effective rate in the study group was 96.97%，which was significantly higher than 81.81% in the control group，with significant difference(P<0.05).The index of β-collagen degradation products in the study group was significantly lower than that in the control group and before treatment，with significant difference(P<0.05). Conclusion Bushen Tianjing Huoxue formula can effectively enhance the bone density，improve the clinical symptoms and reduce the concentration of β-collagen degradation products.It is safe and reliable，it is worthy of clinical promotion and application.
[Key words] Bushen Tianjing Huoxue formula；Osteoporosis；β-collagen degradation products
骨质疏松症(osteoporosis，OP)是由多种原因所致的骨科疾病，骨组织可见正常钙化，基质与钙盐呈正常比例，主要以单位体积内骨组织降低为特点，患病者易出现骨折、骨骼疼痛等症状。近年来，随着我国人口逐渐步入老龄化，该病的发生率也呈显著上升趋势，严重影响了人们的健康及生活质量[1]。本院中医风湿科根据OP的特点，结合祖国医学理论，以补肾填精活血之法为治疗原则，自拟补肾填精活血方药，临床应用效果显著，可以有效强化骨密度，降低β-胶原降解产物水平，促使骨形成。
1 资料与方法
1.1 一般资料
选择2012年1月～2014年1月本院收治的132例原发性OP患者作为研究对象，根据随机数字表法将其分为研究组与对照组，各66例。研究组中，男30例，女36例；年龄46～83岁，平均(53.6±3.6)岁；病程1～9年，平均(5.2±2.2)年。对照组中，男29例，女37例；年龄45～82岁，平均(53.5±3.2)岁；病程1～8.5年，平均(5.3±2.3)年。两组的性别、年龄、病程等一般资料比较，差异有统计学意义(P>0.05)，具有可比性。
1.2 入选标准
①中医诊断标准：参照《中药新药临床研究指导原则》[2]中的OP诊断标准，以腰膝酸软，腰背酸痛为主症；以脊背压痛或叩击痛，不耐久立久坐，不能持重，耳鸣眩晕，易疲乏为次症，舌质偏红或淡，脉细。②西医诊断标准：参照刘忠厚编写的《中骨质疏松症》[3]中的OP诊断标准，骨密度低于同性别健康人群峰值的2个标准差以上。③对本次研究知情，并签署知情同意书。 (廖康汉等)
[关键词] 补肾填精活血方；骨质疏松症；β-胶原降解产物
[中图分类号] R681 [文献标识码] A [文章编号] 1674-4721(2015)02(a)-0106-03
Effect of Bushen Tianjing Huoxue formula in the treatment of osteoporosis and influence on β-crosslaps degradation products
LIAO Kang-han LI De-yu ZHU Hui-jun LUO Xiao-guang TAN Ning
Department of Rheumatology of Traditional Chinese Medicine，Affiliated Nanshan Hospital of Guangdong Medical College，Shenzhen 518052，China
[Abstract] Objective To explore the effect of Bushen Tianjing Huoxue formula on patients with osteoporosis (OP) and influence on β-collagen degradation products. Methods 132 cases of OP were selected and randomly divided into the study group and the control group.The control group was treated with vitamin D，calcium carbonate D3 and calcitriol soft capsules，the study group was treated with Bushen Tianjing Huoxue formula.The total effective rate and the index of β-collagen degradation products in two groups was compared. Results The total effective rate in the study group was 96.97%，which was significantly higher than 81.81% in the control group，with significant difference(P<0.05).The index of β-collagen degradation products in the study group was significantly lower than that in the control group and before treatment，with significant difference(P<0.05). Conclusion Bushen Tianjing Huoxue formula can effectively enhance the bone density，improve the clinical symptoms and reduce the concentration of β-collagen degradation products.It is safe and reliable，it is worthy of clinical promotion and application.
[Key words] Bushen Tianjing Huoxue formula；Osteoporosis；β-collagen degradation products
骨质疏松症(osteoporosis，OP)是由多种原因所致的骨科疾病，骨组织可见正常钙化，基质与钙盐呈正常比例，主要以单位体积内骨组织降低为特点，患病者易出现骨折、骨骼疼痛等症状。近年来，随着我国人口逐渐步入老龄化，该病的发生率也呈显著上升趋势，严重影响了人们的健康及生活质量[1]。本院中医风湿科根据OP的特点，结合祖国医学理论，以补肾填精活血之法为治疗原则，自拟补肾填精活血方药，临床应用效果显著，可以有效强化骨密度，降低β-胶原降解产物水平，促使骨形成。
1 资料与方法
1.1 一般资料
选择2012年1月～2014年1月本院收治的132例原发性OP患者作为研究对象，根据随机数字表法将其分为研究组与对照组，各66例。研究组中，男30例，女36例；年龄46～83岁，平均(53.6±3.6)岁；病程1～9年，平均(5.2±2.2)年。对照组中，男29例，女37例；年龄45～82岁，平均(53.5±3.2)岁；病程1～8.5年，平均(5.3±2.3)年。两组的性别、年龄、病程等一般资料比较，差异有统计学意义(P>0.05)，具有可比性。
1.2 入选标准
①中医诊断标准：参照《中药新药临床研究指导原则》[2]中的OP诊断标准，以腰膝酸软，腰背酸痛为主症；以脊背压痛或叩击痛，不耐久立久坐，不能持重，耳鸣眩晕，易疲乏为次症，舌质偏红或淡，脉细。②西医诊断标准：参照刘忠厚编写的《中骨质疏松症》[3]中的OP诊断标准，骨密度低于同性别健康人群峰值的2个标准差以上。③对本次研究知情，并签署知情同意书。 (廖康汉等)