糖皮质激素联合特布他林治疗慢性阻塞性肺疾病加重期的临床观察(1)
[摘要] 目的 探讨糖皮质激素联合特布他林治疗慢性阻塞性肺疾病急性加重期的临床效果。 方法 选取2012年4月～2014年4月本院收治的92例慢性阻塞性肺疾病急性加重期患者，将其随机分为观察组和对照组，每组46例。对照组采用特布他林治疗，观察组在对照治疗的基础上添加糖皮质激素治疗。比较两组的临床疗效，观察两组治疗前后血气指标[动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)]的变化情况等。 结果 观察组总有效率为97.83%，高于对照组的80.43%，差异有统计学意义(P<0.05)。治疗后两组患者的PaO2、PaCO2均有所改善(P<0.05)，且观察组的改善程度明显优于对照组(P<0.05)。 结论 糖皮质激素联合特布他林治疗慢性阻塞性肺疾病急性加重期可有效提高治疗效果，改善患者的生活质量，有较高的应用价值，值得临床推广应用。
[关键词] 慢性阻塞性肺疾病；急性加重期；糖皮质激素；特布他林
[中图分类号] R974 [文献标识码] A [文章编号] 1674-4721(2015)02(b)-0111-03
Clinical observation of glucocorticoid combined with terbutaline in the treatment of acute exacerbation of chronic obstructive pulmonary disease
YU Chang-fa CHEN Xiao-qin
Department of Medicine，the First People′s Hospital of Linchuan District in Fuzhou City of Jiangxi Province，Fuzhou 344100，China
[Abstract] Objective To investigate the clinical efficacy of glucocorticoid combined with terbutaline in the treatment of acute exacerbation of chronic obstructive pulmonary disease. Methods 92 cases of patients with acute exacerbation of chronic obstructive pulmonary disease treated in our hospital from April 2012 to April 2014 were selected，and were randomly divided into observation group and control group，46 cases in each group.The control group were taken with terbutaline，glucocorticoid was added to observation group on the basis of control group.The efficiency of the two groups was compared，arterial partial pressure of oxygen (PaO2) and arterial carbon dioxide partial pressure (PaCO2) changes before and after treatment was observed. Results The total effective rate of observation group was 97.83%，higher than 80.43% of the control group，the difference was significant (P<0.05).After treatment，PaO2 and PaCO2 of the two groups improved compared with before treatment (P<0.05)，and the improvement of observation group was better than that of control group (P<0.05). Conclusion Glucocorticoid combined with terbutaline in the treatment of acute exacerbation of chronic obstructive pulmonary disease can effectively improve the therapeutic effect，and can improve the quality of life，has a higher application value，is worthy widely using in clinic.
[Key words] Chronic obstructive pulmonary disease；Acute exacerbation；Glucocorticoids；Terbutaline
慢性阻塞性肺疾病是临床上较常见的一种呼吸系统疾病[1]，主要并发症呼吸衰竭是引起患者死亡的常见原因，慢性阻塞性肺疾病的发病率高、死亡率高，给患者的生活质量带来负面影响[2]。因此，及时采取有效的措施进行治疗，以提高治疗效果，改善患者的生活质量显得尤为重要。随着医疗水平的不断发展，临床上逐渐将糖皮质激素联合特布他林应用于慢性阻塞性肺疾病的治疗中，并取得了一定的效果[3]。本文探讨慢性阻塞性肺疾病急性加重期采用糖皮质激素联合特布他林治疗的临床效果。 (喻长发 陈小琴)
[关键词] 慢性阻塞性肺疾病；急性加重期；糖皮质激素；特布他林
[中图分类号] R974 [文献标识码] A [文章编号] 1674-4721(2015)02(b)-0111-03
Clinical observation of glucocorticoid combined with terbutaline in the treatment of acute exacerbation of chronic obstructive pulmonary disease
YU Chang-fa CHEN Xiao-qin
Department of Medicine，the First People′s Hospital of Linchuan District in Fuzhou City of Jiangxi Province，Fuzhou 344100，China
[Abstract] Objective To investigate the clinical efficacy of glucocorticoid combined with terbutaline in the treatment of acute exacerbation of chronic obstructive pulmonary disease. Methods 92 cases of patients with acute exacerbation of chronic obstructive pulmonary disease treated in our hospital from April 2012 to April 2014 were selected，and were randomly divided into observation group and control group，46 cases in each group.The control group were taken with terbutaline，glucocorticoid was added to observation group on the basis of control group.The efficiency of the two groups was compared，arterial partial pressure of oxygen (PaO2) and arterial carbon dioxide partial pressure (PaCO2) changes before and after treatment was observed. Results The total effective rate of observation group was 97.83%，higher than 80.43% of the control group，the difference was significant (P<0.05).After treatment，PaO2 and PaCO2 of the two groups improved compared with before treatment (P<0.05)，and the improvement of observation group was better than that of control group (P<0.05). Conclusion Glucocorticoid combined with terbutaline in the treatment of acute exacerbation of chronic obstructive pulmonary disease can effectively improve the therapeutic effect，and can improve the quality of life，has a higher application value，is worthy widely using in clinic.
[Key words] Chronic obstructive pulmonary disease；Acute exacerbation；Glucocorticoids；Terbutaline
慢性阻塞性肺疾病是临床上较常见的一种呼吸系统疾病[1]，主要并发症呼吸衰竭是引起患者死亡的常见原因，慢性阻塞性肺疾病的发病率高、死亡率高，给患者的生活质量带来负面影响[2]。因此，及时采取有效的措施进行治疗，以提高治疗效果，改善患者的生活质量显得尤为重要。随着医疗水平的不断发展，临床上逐渐将糖皮质激素联合特布他林应用于慢性阻塞性肺疾病的治疗中，并取得了一定的效果[3]。本文探讨慢性阻塞性肺疾病急性加重期采用糖皮质激素联合特布他林治疗的临床效果。 (喻长发 陈小琴)