盐酸文拉法辛治疗慢性疼痛的临床效果(1)
[摘要] 目的 探讨盐酸文拉法辛治疗慢性疼痛的临床效果。 方法 将本院2012年3月～2014年4月治疗的慢性疼痛患者80例作为研究对象，按其临床治疗方法分为观察组和对照组，每组40例，对照组患者借助临床常用止痛药物治疗，观察组在对照组治疗的基础给予盐酸文拉法辛，观察两组的治疗效果。 结果 观察组治疗总有效率为95.0%，高于对照组的80.0%，差异有统计学意义(P<0.05)；观察组患者睡眠质量评分为(6.01±0.86)分、疼痛评分为(0.83±0.33)分，对照组患者睡眠质量评分为(10.55±1.52)分、疼痛评分为(2.45±0.39)分，两组差异有统计学意义(P<0.05)；观察组不良反应发生率为7.5%，低于对照组的22.5%，差异有统计学意义(P<0.05)。 结论 借助盐酸文拉法辛治疗慢性疼痛，临床效果显著，可提高患者的生活、睡眠质量，降低不良反应发生率，值得推广应用。
[关键词] 盐酸文拉法辛；慢性疼痛；临床效果
[中图分类号] R971 [文献标识码] A [文章编号] 1674-4721(2015)02(b)-0134-03
Clinical effect of venlafaxine hydrochloride in the treatment of chronic pain
CHEN Sheng-hui
Department of Internal Medicine，Suzhou Jiulong Hospital of Shanghai Jiaotong University School of Medicine，Shanghai 215000，China
[Abstract] Objective To investigate the clinical effect of venlafaxine hydrochloride in treatment of chronic pain. Methods 80 patients with chronic pain treated in our hospital from March 2012 to April 2014 were selected as research objects，and were divided into observation group and control group according to the different treatment，each group of 40 cases，control group were taken with clinical commonly used pain medications，the observation group were given with venlafaxine hydrochloride on the basis of control group，the clinical efficacy of two groups was observed. Results The total effective rate of observation group was 95.0%，higher than 80.0% of control group，the difference was significant (P<0.05).The quality of sleep score in observation group was 6.01±0.86，pain score was 0.83±0.33，and the control group was 10.55±1.52 and 2.45±0.39 respectively，the difference between the two groups was significant (P<0.05).The incidence of adverse reactions in observation group was 7.5%，lower than 22.5% of the control group，the difference was significance (P<0.05). Conclusion With the help of venlafaxine hydrochloride in treating chronic pain has significant clinical effect，can improve the sleep quality of life，and reduce the incidence of adverse reactions，it is worth promoting in clinic.
[Key words] Venlafaxine hydrochloride；Chronic pain；Clinical effect
慢性疼痛是临床常见病，普通人群发病率较高，具有发作时间长、反复性发作等临床特点。慢性疾病患者由于患病时间逐渐延长，均借助各种药物治疗，严重影响日常工作和生活[1]。尤其是大量止痛药物的应用，极易造成药物成瘾等严重并发症。一般来说，慢性疼痛患者抑郁严重，不但影响患者的日常工作和生活，还危害患者的身心健康。本院通过不断研究发现，盐酸文拉法辛不仅可有效缓解患者的抑郁现状，临床效果也较显著。本文探讨盐酸文拉法辛治疗慢性疼痛的临床效果。
1 资料与方法
1.1 一般资料
将本院2012年3月～2014年4月治疗的慢性疼痛患者80例作为研究对象，按其临床治疗方法分为观察组和对照组)，其中，观察组患者40例，男性22例，女性18例；年龄22～62岁，平均(45.5±2.5)岁；病程2～5年，平均(4.0±0.2)年；腰部疼痛12例，头痛20例，四肢疼痛8例。对照组患者40例，男性24例，女性16例；年龄23～65岁，平均(47.5±2.9)岁；病程2～6年，平均(4.2±0.5)年；腰部疼痛13例，头痛17例，四肢疼痛10例。两组患者的性别、年龄、病程、疼痛部位等资料差异无统计学意义(P>0.05)，具有可比性。 (陈胜会)
[关键词] 盐酸文拉法辛；慢性疼痛；临床效果
[中图分类号] R971 [文献标识码] A [文章编号] 1674-4721(2015)02(b)-0134-03
Clinical effect of venlafaxine hydrochloride in the treatment of chronic pain
CHEN Sheng-hui
Department of Internal Medicine，Suzhou Jiulong Hospital of Shanghai Jiaotong University School of Medicine，Shanghai 215000，China
[Abstract] Objective To investigate the clinical effect of venlafaxine hydrochloride in treatment of chronic pain. Methods 80 patients with chronic pain treated in our hospital from March 2012 to April 2014 were selected as research objects，and were divided into observation group and control group according to the different treatment，each group of 40 cases，control group were taken with clinical commonly used pain medications，the observation group were given with venlafaxine hydrochloride on the basis of control group，the clinical efficacy of two groups was observed. Results The total effective rate of observation group was 95.0%，higher than 80.0% of control group，the difference was significant (P<0.05).The quality of sleep score in observation group was 6.01±0.86，pain score was 0.83±0.33，and the control group was 10.55±1.52 and 2.45±0.39 respectively，the difference between the two groups was significant (P<0.05).The incidence of adverse reactions in observation group was 7.5%，lower than 22.5% of the control group，the difference was significance (P<0.05). Conclusion With the help of venlafaxine hydrochloride in treating chronic pain has significant clinical effect，can improve the sleep quality of life，and reduce the incidence of adverse reactions，it is worth promoting in clinic.
[Key words] Venlafaxine hydrochloride；Chronic pain；Clinical effect
慢性疼痛是临床常见病，普通人群发病率较高，具有发作时间长、反复性发作等临床特点。慢性疾病患者由于患病时间逐渐延长，均借助各种药物治疗，严重影响日常工作和生活[1]。尤其是大量止痛药物的应用，极易造成药物成瘾等严重并发症。一般来说，慢性疼痛患者抑郁严重，不但影响患者的日常工作和生活，还危害患者的身心健康。本院通过不断研究发现，盐酸文拉法辛不仅可有效缓解患者的抑郁现状，临床效果也较显著。本文探讨盐酸文拉法辛治疗慢性疼痛的临床效果。
1 资料与方法
1.1 一般资料
将本院2012年3月～2014年4月治疗的慢性疼痛患者80例作为研究对象，按其临床治疗方法分为观察组和对照组)，其中，观察组患者40例，男性22例，女性18例；年龄22～62岁，平均(45.5±2.5)岁；病程2～5年，平均(4.0±0.2)年；腰部疼痛12例，头痛20例，四肢疼痛8例。对照组患者40例，男性24例，女性16例；年龄23～65岁，平均(47.5±2.9)岁；病程2～6年，平均(4.2±0.5)年；腰部疼痛13例，头痛17例，四肢疼痛10例。两组患者的性别、年龄、病程、疼痛部位等资料差异无统计学意义(P>0.05)，具有可比性。 (陈胜会)