复方盐酸普鲁卡因胶囊治疗围绝经期功能失调性子宫出血的效果观察(1)
[摘要] 目的 探讨复方盐酸普鲁卡因胶囊治疗围绝经期功能失调性子宫出血的临床效果。 方法 以数字法抽选妇科门诊2012年6月～2014年6月收治的99例围绝经期功能失调性子宫出血患者，将其随机分为观察组(52例)和对照组(47例)，观察组给予复方盐酸普鲁卡因胶囊治疗，对照组采用炔诺酮治疗，连续用药3个月，观察两组患者的临床症状，监测治疗前后血红蛋白值、子宫内膜厚度、血激素水平变化。 结果 观察组总有效率为94.23%，明显高于对照组的74.47%，差异有统计学意义(P<0.05)；治疗后观察组血红蛋白值高于对照组、子宫内膜厚度低于对照组、血清FSH/LH比值高于对照组，差异有统计学意义(P<0.05)。 结论 复方盐酸普鲁卡因胶囊能有效改善围绝经期功能失调性子宫出血，有助于各项指标恢复正常，值得临床应用。
[关键词] 复方盐酸普鲁卡因胶囊；围绝经期；功能失调性子宫出血；激素水平
[中图分类号] R711.52 [文献标识码] A [文章编号] 1674-4721(2015)02(b)-0136-03
Efficacy observation of compound procaine hydrochloride capsules in treatment of perimenopausal dysfunctional uterine bleeding
GAN Qin1 LIAN Xiao-qin2 LUO Zhong-ming2
1.Department of Pharmacy，the Central Hospital of Jiangmen City in Guangdong Province，Jiangmen 529000，China；2.Department of Obstetrics and Gynecology，the Central Hospital of Jiangmen City in Guangdong Province，Jiangmen 529000，China
[Abstract] Objective To investigate the clinical efficacy of compound procaine hydrochloride capsules in the treatment of perimenopausal dysfunctional uterine bleeding. Methods 99 patients with perimenopausal dysfunctional uterine bleeding in our hospital from June 2012 to June 2014 were selected by using digital method，and were randomly divided into observation group (52 cases) and control group (47 cases).The observation group were given with compound procaine hydrochloride capsules for treatment，the control group were given with norethisterone for treatment.Both groups were treated for three months.Meanwhile，clinical symptoms of the two groups was observed，endometrial thickness，hemoglobin and blood hormone level before and after treatment was monitored. Results The total effective rate of observation group was 94.23%，higher than74.47% in control group (P<0.05).Moreover the hemoglobin values and endometrial thickness of the observation group was better than that of the control group after the treatment (P<0.05).The serum FSH/LH ratio of observation group was higher than that of the control group (P<0.05). Conclusion Compound procaine hydrochloride capsules can effectively improve clinical curative effect of perimenopausal dysfunctional uterine bleeding，conducive to help each index back to normal，which is worthy of clinical application.
[Key words] Compound procaine hydrochloride capsules；Perimenopausal period；Dysfunctional uterine bleeding；Hormone levels
围绝经期功能失调性子宫出血是妇科常见疾病，发病率约为10%，主要临床表现以月经周期紊乱、月经量过多、不规则出血、经期延长为主，长期反复出血又可能引起感染、贫血等一系列并发症，发生严重子宫内膜病变者只能采取手术切除子宫止血[1]。目前临床治疗该病主要是刮宫止血与药物治疗，其中口服孕激素治疗是常用的保守治疗方案，但从治疗依从性和长期服药产生的的不良反应影响临床疗效来看，不能达到预期效果[2-3]。本研究探讨复方盐酸普鲁卡因胶囊治疗围绝经期功能失调性子宫出血的临床效果。 (甘琴等)
[关键词] 复方盐酸普鲁卡因胶囊；围绝经期；功能失调性子宫出血；激素水平
[中图分类号] R711.52 [文献标识码] A [文章编号] 1674-4721(2015)02(b)-0136-03
Efficacy observation of compound procaine hydrochloride capsules in treatment of perimenopausal dysfunctional uterine bleeding
GAN Qin1 LIAN Xiao-qin2 LUO Zhong-ming2
1.Department of Pharmacy，the Central Hospital of Jiangmen City in Guangdong Province，Jiangmen 529000，China；2.Department of Obstetrics and Gynecology，the Central Hospital of Jiangmen City in Guangdong Province，Jiangmen 529000，China
[Abstract] Objective To investigate the clinical efficacy of compound procaine hydrochloride capsules in the treatment of perimenopausal dysfunctional uterine bleeding. Methods 99 patients with perimenopausal dysfunctional uterine bleeding in our hospital from June 2012 to June 2014 were selected by using digital method，and were randomly divided into observation group (52 cases) and control group (47 cases).The observation group were given with compound procaine hydrochloride capsules for treatment，the control group were given with norethisterone for treatment.Both groups were treated for three months.Meanwhile，clinical symptoms of the two groups was observed，endometrial thickness，hemoglobin and blood hormone level before and after treatment was monitored. Results The total effective rate of observation group was 94.23%，higher than74.47% in control group (P<0.05).Moreover the hemoglobin values and endometrial thickness of the observation group was better than that of the control group after the treatment (P<0.05).The serum FSH/LH ratio of observation group was higher than that of the control group (P<0.05). Conclusion Compound procaine hydrochloride capsules can effectively improve clinical curative effect of perimenopausal dysfunctional uterine bleeding，conducive to help each index back to normal，which is worthy of clinical application.
[Key words] Compound procaine hydrochloride capsules；Perimenopausal period；Dysfunctional uterine bleeding；Hormone levels
围绝经期功能失调性子宫出血是妇科常见疾病，发病率约为10%，主要临床表现以月经周期紊乱、月经量过多、不规则出血、经期延长为主，长期反复出血又可能引起感染、贫血等一系列并发症，发生严重子宫内膜病变者只能采取手术切除子宫止血[1]。目前临床治疗该病主要是刮宫止血与药物治疗，其中口服孕激素治疗是常用的保守治疗方案，但从治疗依从性和长期服药产生的的不良反应影响临床疗效来看，不能达到预期效果[2-3]。本研究探讨复方盐酸普鲁卡因胶囊治疗围绝经期功能失调性子宫出血的临床效果。 (甘琴等)