别嘌呤醇治疗急性脑梗死伴高尿酸血症的临床效果(1)
[摘要] 目的 探讨别嘌呤醇治疗急性脑梗死伴高尿酸血症的临床效果。 方法 选取2013年10月～2014年10月本院收治的80例急性脑梗死伴高尿酸血症患者作为研究对象，随机分为对照组和观察组，各40例。对照组给予抗凝、抗血小板聚集等对症治疗，观察组在对照组的基础上给予别嘌呤醇，比较两组治疗前后的血清尿酸水平、神经功能缺损评分以及临床效果。 结果 两组治疗后的血清尿酸水平与神经功能缺损评分显著低于治疗前，差异有统计学意义(P<0.05)。观察组治疗后的血清尿酸水平与神经功能缺损评分显著低于对照组治疗后，差异有统计学意义(P<0.05)。观察组的总有效率为92.5%，显著高于对照组的75.0%，差异有统计学意义(P<0.05)。 结论 别嘌呤醇能够明显降低急性脑梗死伴高尿酸血症患者的血清尿酸水平，改善患者的神经功能缺损症状，值得临床推广应用。
[关键词] 别嘌呤醇；高尿酸血症；急性脑梗死；疗效
[中图分类号] R743.3 [文献标识码] A [文章编号] 1674-4721(2015)05(b)-0114-03
Clinical effect of allopurinol in the treatment of acute cerebral infarction combined with hyperuricemia
GUO Jian-jun NI Xiao-jun SHI Li LIU Jiu-di WU Xiao-yan WEI Wei-min
Department of Neurology，People′s Hospital of Zengcheng City in Guangdong Province，Zengcheng 511300，China
[Abstract] Objective To explore the clinical effect of allopurinol in the treatment of acute cerebral infarction combined with hyperuricemia. Methods 80 patients with acute cerebral infarction combined with hyperuricemia from October 2013 to October 2014 in our hospital were selected and randomly divided into the control group and the observation group，40 cases in each group.The control group was given symptomatic treatment like anticoagulant and anti-platelet aggregation，the observation group was treated with allopurinol on the basis of the control group.The level of serum uric acid，the score of neurological function defect and clinical effect before and after treatment in two groups was compared. Results The level of serum uric acid and the score of neurological function defect in two groups after treatment was lower than that before treatment，with significant difference(P<0.05).The level of serum uric acid and the score of neurological function defect in the observation group after treatment was lower than that in the control group after treatment，with significant difference(P<0.05).The total effective rate in the observation group was 92.5%，which was higher than 75.0% in the control group，with significant difference(P<0.05). Conclusion Allopurinol can significantly reduce serum uric acid level and improve symptoms of neurological function defect in patients with acute cerebral infarction combined with hyperuricemia，it is worthy of clinical promotion and application.
[Key words] Allopurinol；Hyperuricemia；Acute cerebral infarction；Efficacy
急性脑梗死是临床常见的疾病之一，起病急、进展快、复发率高，具有较高的致残率和致死率，严重影响患者的生活质量及生命安全。近年来的研究显示，高尿酸血症与急性脑梗死的发生、发展具有密切相关性[1-3]，当血清尿酸水平增高时，急性脑梗死患者的预后质量相对较差。别嘌呤醇作为黄嘌呤氧化酶抑制剂，能够有效抑制尿酸生成[4]。本研究选取本院的急性脑梗死伴高尿酸血症患者作为研究对象，探讨别嘌呤醇的治疗效果。 (郭建军 倪晓俊 史丽 刘就娣 吴小燕 )
[关键词] 别嘌呤醇；高尿酸血症；急性脑梗死；疗效
[中图分类号] R743.3 [文献标识码] A [文章编号] 1674-4721(2015)05(b)-0114-03
Clinical effect of allopurinol in the treatment of acute cerebral infarction combined with hyperuricemia
GUO Jian-jun NI Xiao-jun SHI Li LIU Jiu-di WU Xiao-yan WEI Wei-min
Department of Neurology，People′s Hospital of Zengcheng City in Guangdong Province，Zengcheng 511300，China
[Abstract] Objective To explore the clinical effect of allopurinol in the treatment of acute cerebral infarction combined with hyperuricemia. Methods 80 patients with acute cerebral infarction combined with hyperuricemia from October 2013 to October 2014 in our hospital were selected and randomly divided into the control group and the observation group，40 cases in each group.The control group was given symptomatic treatment like anticoagulant and anti-platelet aggregation，the observation group was treated with allopurinol on the basis of the control group.The level of serum uric acid，the score of neurological function defect and clinical effect before and after treatment in two groups was compared. Results The level of serum uric acid and the score of neurological function defect in two groups after treatment was lower than that before treatment，with significant difference(P<0.05).The level of serum uric acid and the score of neurological function defect in the observation group after treatment was lower than that in the control group after treatment，with significant difference(P<0.05).The total effective rate in the observation group was 92.5%，which was higher than 75.0% in the control group，with significant difference(P<0.05). Conclusion Allopurinol can significantly reduce serum uric acid level and improve symptoms of neurological function defect in patients with acute cerebral infarction combined with hyperuricemia，it is worthy of clinical promotion and application.
[Key words] Allopurinol；Hyperuricemia；Acute cerebral infarction；Efficacy
急性脑梗死是临床常见的疾病之一，起病急、进展快、复发率高，具有较高的致残率和致死率，严重影响患者的生活质量及生命安全。近年来的研究显示，高尿酸血症与急性脑梗死的发生、发展具有密切相关性[1-3]，当血清尿酸水平增高时，急性脑梗死患者的预后质量相对较差。别嘌呤醇作为黄嘌呤氧化酶抑制剂，能够有效抑制尿酸生成[4]。本研究选取本院的急性脑梗死伴高尿酸血症患者作为研究对象，探讨别嘌呤醇的治疗效果。 (郭建军 倪晓俊 史丽 刘就娣 吴小燕 )