中西医结合治疗LEEP术后HPV持续感染的临床研究(1)
[摘要] 目的 观察中西医结合治疗LEEP术后HPV持续感染的临床效果。 方法 选择2013年1～12月在常熟市中医院妇科就诊的CIN行LEEP术，术后3个月复查，行阴道镜检查阴性，但HPV持续阳性的患者100例为入组病例，随机将其分为治疗组(50例)和对照组(50例)，治疗组采用妇安宁洗剂外用联合重组人干扰素α-2b栓治疗，对照组采用重组人干扰素α-2b栓治疗。两组治疗疗程均为3个月，停药后9个月复查，观察两组的HPV转阴率等。 结果 治疗组的HPV转阴率为64%，对照组为32%，两组比较，差异有统计学意义(P<0.05)；两组的宫颈创面大部分在4周内愈合，治疗组中，创面愈合时间>4周10例，术后出血4例，宫颈管息肉样增生5例；对照组愈合时间>4周14例、术后出血6例，宫颈管息肉样增生8例，两组的上述情况差异有统计学意义(P<0.05)。 结论 妇安宁洗剂外用联合重组人干扰素α-2b栓治疗LEEP术后HPV持续感染的临床效果显著，可干预HPV持续感染，延缓宫颈病变的发生，值得临床推广应用。
[关键词] 中西医结合；宫颈环形电切术；妇安宁洗剂；人乳头瘤病毒；干预
[中图分类号] R713.4 [文献标识码] A [文章编号] 1674-4721(2015)05(b)-0132-03
Clinical study of integrated traditional Chinese and western medicine treating HPV persistent infection after LEEP surgery
WANG Chun-lan YAN Hong-yue
Department of Gynaecology and Obstetrics，Changshu Traditional Chinese Medicine Hospital of Jiangsu Province，Changshu 215500，China
[Abstract] Objective To observe the clinical effect of integrated traditional Chinese and western medicine treating human papilloma virus (HPV) persistent infection after loop electrosurgical excision procedure (LEEP) surgery. Methods From January to December in 2013，100 patients with CIN given LEEP surgerytreated in department of gynaecology of Changshu Traditional Chinese Medicine Hospital，and patients given reexamination after 3 months surgery were HPV persistent positive andnegative by colposcopy examination and selected.They were evenly divided into treatment group and control group in random.In treatment group，fuanning lotion for external use combined with recombinant human interferon α-2b suppository was adopted，while in control group，only recombinant human interferon α-2b suppository was used.The course of treatment in both groups was 3 months.Reexamination was carried out 9 months after ceasing medication，the negative conversion rate of HPV infection and so on was observed in two groups. Results The negative conversion rate in treatment group and control group was 64% and 32% respectively，which displayed a statistical difference after comparison (P<0.05).Most cervical wound would be healed within 4 weeks.In treatment group，there were 10 cases whose wound healing time were over 4 weeks，and 4 cases occurred with postoperative bleeding，polypoid hyperplasia in cervical canal was 5 cases，while in control group，there were 14 cases whose wound healing rate were more than 4 weeks，6 cases with postoperative bleeding，and 8 cases with polypoid hyperplasia in cervical canal，which all displayed statistical differences (P<0.05). Conclusion The clinical effect of fuanning lotion for external use combined with recombinant human interferon α-2b suppository treating human papilloma virus (HPV) persistent infection after loop electrosurgical excision procedure (LEEP) surgery is significantl and can intervene in HPV persistent infection and prolong the occurrence of cervical lesions，which is worthy of application and expansion in clinic. (王春兰 严虹月)
[关键词] 中西医结合；宫颈环形电切术；妇安宁洗剂；人乳头瘤病毒；干预
[中图分类号] R713.4 [文献标识码] A [文章编号] 1674-4721(2015)05(b)-0132-03
Clinical study of integrated traditional Chinese and western medicine treating HPV persistent infection after LEEP surgery
WANG Chun-lan YAN Hong-yue
Department of Gynaecology and Obstetrics，Changshu Traditional Chinese Medicine Hospital of Jiangsu Province，Changshu 215500，China
[Abstract] Objective To observe the clinical effect of integrated traditional Chinese and western medicine treating human papilloma virus (HPV) persistent infection after loop electrosurgical excision procedure (LEEP) surgery. Methods From January to December in 2013，100 patients with CIN given LEEP surgerytreated in department of gynaecology of Changshu Traditional Chinese Medicine Hospital，and patients given reexamination after 3 months surgery were HPV persistent positive andnegative by colposcopy examination and selected.They were evenly divided into treatment group and control group in random.In treatment group，fuanning lotion for external use combined with recombinant human interferon α-2b suppository was adopted，while in control group，only recombinant human interferon α-2b suppository was used.The course of treatment in both groups was 3 months.Reexamination was carried out 9 months after ceasing medication，the negative conversion rate of HPV infection and so on was observed in two groups. Results The negative conversion rate in treatment group and control group was 64% and 32% respectively，which displayed a statistical difference after comparison (P<0.05).Most cervical wound would be healed within 4 weeks.In treatment group，there were 10 cases whose wound healing time were over 4 weeks，and 4 cases occurred with postoperative bleeding，polypoid hyperplasia in cervical canal was 5 cases，while in control group，there were 14 cases whose wound healing rate were more than 4 weeks，6 cases with postoperative bleeding，and 8 cases with polypoid hyperplasia in cervical canal，which all displayed statistical differences (P<0.05). Conclusion The clinical effect of fuanning lotion for external use combined with recombinant human interferon α-2b suppository treating human papilloma virus (HPV) persistent infection after loop electrosurgical excision procedure (LEEP) surgery is significantl and can intervene in HPV persistent infection and prolong the occurrence of cervical lesions，which is worthy of application and expansion in clinic. (王春兰 严虹月)