高压氧治疗外伤性癫痫的临床效果观察(1)
[摘要] 目的 探讨高压氧治疗外伤性癫痫的临床效果。 方法 选取2012年6月～2013年6月本院收治的60例外伤性癫痫患者作为研究对象，随机分为观察组与对照组，各30例。对照组给予常规治疗，观察组在对照组的基础上采用高压氧治疗，比较两组的临床效果。 结果 观察组的总有效率为96.67%，显著高于对照组的66.67%，差异有统计学意义(P<0.05)。观察组治疗后的癫痫发作次数显著少于对照组，差异有统计学意义(P<0.05)。观察组治疗后的发作持续时间显著短于对照组，差异有统计学意义(P<0.05)。 结论 高压氧治疗外伤性癫痫效果显著，能够有效减少癫痫发作次数，缩短发作持续时间，值得临床推广应用。
[关键词] 高压氧；外伤性；癫痫
[中图分类号] R742.1 [文献标识码] A [文章编号] 1674-4721(2015)07(b)-0029-03
[Abstract] Objective To explore the clinical effect of hyperbaric oxygenation (HBO) in the treatment of posttraumatic epilepsy. Methods 60 patients of posttraumatic epilepsy from June 2012 to June 2013 in our hospital were selected and randomly divided into the observation group and the control group，30 cases in each group.The control group was treated with routine therapy，the observation group was given HBO on the basis of the control group.The clinical efficacy in two groups was compared. Results The total effective rate in the observation group was 96.67%，which was higher than 66.00% in the control group，with significant dafference(P<0.05).The attack frequency of epilepsy in the observation group after treatment was less than that in the control group，with significant dafference(P<0.05).The attack duration of epilepsy in the observation group after treatment was shorter than that in the control group，with significant dafference(P<0.05). Conclusion The effect of HBO in the treatment of posttraumatic epilepsy is significant，which can effectively reduce attack frequency of epilepsy and shorten attack duration of epilepsy，it is worthy of clinical promotion and application.
[Key words] Hyperbaric oxygenation；Traumatism；Epilepsy
外伤性癫痫是一种严重的颅脑外伤后并发症，病情进展缓慢，反复发作[1]，需要长期治疗。在外伤性癫痫治疗中，手术治疗往往难以取得良好的效果，容易发展成难治性癫痫[2]。随着医疗水平的发展，高压氧逐渐成为治疗外伤性癫痫的重要手段，其效果显著，能够有效控制癫痫的发作频率，促进患者心电图恢复[3]。本研究选取本院收治的外伤性癫痫患者作为研究对象，分别采取常规治疗与高压氧治疗，旨在探讨高压氧治疗外伤性癫痫的临床效果。
1 资料与方法
1.1一般资料
选取2012年6月～2013年6月本院收治的60例外伤性癫痫患者作为研究对象，均符合外伤性癫痫的诊断标准[4]。将入选患者随机分为观察组与对照组，各30例。观察组中，男16例，女14例；年龄为17～59岁，平均(38.43±5.33)岁；其中早期癫痫13 例，中期癫痫10例，晚期癫痫7例；大发作10例，小发作9例，局限性发作7例，精神运动性发作4例。对照组中，男17例，女13例；年龄为18～57岁，平均(38.80±5.15)岁；其中早期癫痫12例，中期癫痫9例，晚期癫痫9例；大发作11例，小发作8例，局限性发作6例，精神运动性发作5例。两组的性别、年龄、病情等一般资料比较，差异无统计学意义(P>0.05)，具有可比性。
1.2方法
对照组采用卡马西平或丙戊酸钠、控制血压、抗感染、营养神经、扩血管、改善脑细胞代谢及脑循环等常规治疗。急性癫痫发作期给予静脉注射地西泮；持续性癫痫发作患者在注射地西泮的同时，使用苯巴比妥、硫喷妥钠等；在癫痫发作缓解后，给予患者口服丙戊酸钠，总疗程为1年。治疗组在对照组治疗的基础上给予高压氧治疗，选择6人卧式医用氧舱，压力2.0 TAT，升压时间为10 min，降压时间为10 min，稳压时戴面罩吸氧，30 min/次，中间休息5 min，1次/d。1个疗程为12次，共治疗4个疗程。 (王大春)
[关键词] 高压氧；外伤性；癫痫
[中图分类号] R742.1 [文献标识码] A [文章编号] 1674-4721(2015)07(b)-0029-03
[Abstract] Objective To explore the clinical effect of hyperbaric oxygenation (HBO) in the treatment of posttraumatic epilepsy. Methods 60 patients of posttraumatic epilepsy from June 2012 to June 2013 in our hospital were selected and randomly divided into the observation group and the control group，30 cases in each group.The control group was treated with routine therapy，the observation group was given HBO on the basis of the control group.The clinical efficacy in two groups was compared. Results The total effective rate in the observation group was 96.67%，which was higher than 66.00% in the control group，with significant dafference(P<0.05).The attack frequency of epilepsy in the observation group after treatment was less than that in the control group，with significant dafference(P<0.05).The attack duration of epilepsy in the observation group after treatment was shorter than that in the control group，with significant dafference(P<0.05). Conclusion The effect of HBO in the treatment of posttraumatic epilepsy is significant，which can effectively reduce attack frequency of epilepsy and shorten attack duration of epilepsy，it is worthy of clinical promotion and application.
[Key words] Hyperbaric oxygenation；Traumatism；Epilepsy
外伤性癫痫是一种严重的颅脑外伤后并发症，病情进展缓慢，反复发作[1]，需要长期治疗。在外伤性癫痫治疗中，手术治疗往往难以取得良好的效果，容易发展成难治性癫痫[2]。随着医疗水平的发展，高压氧逐渐成为治疗外伤性癫痫的重要手段，其效果显著，能够有效控制癫痫的发作频率，促进患者心电图恢复[3]。本研究选取本院收治的外伤性癫痫患者作为研究对象，分别采取常规治疗与高压氧治疗，旨在探讨高压氧治疗外伤性癫痫的临床效果。
1 资料与方法
1.1一般资料
选取2012年6月～2013年6月本院收治的60例外伤性癫痫患者作为研究对象，均符合外伤性癫痫的诊断标准[4]。将入选患者随机分为观察组与对照组，各30例。观察组中，男16例，女14例；年龄为17～59岁，平均(38.43±5.33)岁；其中早期癫痫13 例，中期癫痫10例，晚期癫痫7例；大发作10例，小发作9例，局限性发作7例，精神运动性发作4例。对照组中，男17例，女13例；年龄为18～57岁，平均(38.80±5.15)岁；其中早期癫痫12例，中期癫痫9例，晚期癫痫9例；大发作11例，小发作8例，局限性发作6例，精神运动性发作5例。两组的性别、年龄、病情等一般资料比较，差异无统计学意义(P>0.05)，具有可比性。
1.2方法
对照组采用卡马西平或丙戊酸钠、控制血压、抗感染、营养神经、扩血管、改善脑细胞代谢及脑循环等常规治疗。急性癫痫发作期给予静脉注射地西泮；持续性癫痫发作患者在注射地西泮的同时，使用苯巴比妥、硫喷妥钠等；在癫痫发作缓解后，给予患者口服丙戊酸钠，总疗程为1年。治疗组在对照组治疗的基础上给予高压氧治疗，选择6人卧式医用氧舱，压力2.0 TAT，升压时间为10 min，降压时间为10 min，稳压时戴面罩吸氧，30 min/次，中间休息5 min，1次/d。1个疗程为12次，共治疗4个疗程。 (王大春)