[摘要] 目的 探讨PM2.5暴露对鸦胆子油乳治疗荷瘤肺癌小鼠腹腔巨噬细胞的活性调节作用。 方法 建立肺癌荷瘤A549细胞小鼠模型32只，随机分为4组：治疗组1(鸦胆子油乳治疗组)和对照组1，治疗组2(PM2.5暴露联合鸦胆子油乳治疗组)和对照组2，每组8只。收集腹腔巨噬细胞，检测520 nm吸光度值。 结果 腹腔巨噬细胞吞噬能力显示，治疗组1高于对照组1，差异有统计学意义(P<0.05)；治疗组2低于对照组2及治疗组1高于治疗组2，差异有统计学意义(P<0.01)。 结论 PM2.5暴露对鸦胆子油乳治疗荷瘤肺癌小鼠腹腔巨噬细胞的活性有抑制作用。

    [关键词] 空气细颗粒物；鸦胆子油乳；荷瘤小鼠；腹腔巨噬细胞

    [中图分类号] R332 [文献标识码] A [文章编号] 1674-4721(2016)02(c)-0015-04

    [Abstract] Objective To explore active regulating effect of PM2.5 exposure for peritoneal macrophages of tumor-bearing mice with lung cancer treated by bruceolic oil emulsion. Methods 32 mouse models in tumor-bearing A549 cell in lung cancer were randomly divided into 4 groups：treatment group 1 (bruceolic oil emulsion treatment group) and control group 1 ......