1，6—二磷酸果糖治疗小儿病毒性心肌炎的效果及对心肌酶谱的影响(1)
[摘要] 目的 探讨1，6-二磷酸果糖治疗小儿病毒性心肌炎(VM)的效果及对心肌酶谱的影响。 方法 选取2014年1月～2015年6月在本院接受治疗的30例VM患儿作为研究对象，随机分为观察组及对照组，各15例。对照组采用常规治疗，观察组在对照组的基础上给予1，6-二磷酸果糖，比较两组的治疗效果、心电图及心肌酶谱改善情况。 结果 观察组的治疗总有效率为93.33%，显著高于对照组的73.33%，差异有统计学意义(P<0.05)。观察组心电图恢复正常患儿所占比例为80.00%，显著高于对照组的53.33%，差异有统计学意义(P<0.05)。观察组治疗后的心肌酶水平显著低于对照组治疗后，差异有统计学意义(P<0.05)。 结论 1，6-二磷酸果糖可有效提高小儿VM的治疗效果，显著改善患儿的心电图及心肌酶谱，值得临床推广应用。
[关键词] 1，6-二磷酸果糖；小儿病毒性心肌炎；心肌酶谱
[中图分类号] R725.4 [文献标识码] A [文章编号] 1674-4721(2016)02(c)-0070-03
[Abstract] Objective To explore the effect of 1，6-diphosphate (FDP) in the treatment of children with viral myocarditis and its influence on myocardial enzyme spectrum. Methods 30 children patients with myocardial enzymes (VM) in our hospital from January 2014 to June 2015 were selected and randomly divided into the observation group and the control group，15 cases in each group.The control group was given conventional treatment，the observation group was treated with FDP on the basis of the control group.The treatment effect，the improvement condition of electrocardiogram and myocardial enzyme spectrum in the two groups was compared. Results The totally effective rate of the observation group was 93.33%，which was higher than 73.33% of the control group，with significant difference (P<0.05).The proportion of childrens whose electrocardiogram returned to normal in the observation group was 80.00%，which was higher than 53.33% in the control group，with significant difference (P<0.05).The level of myocardial enzyme after treatment in the observation group was lower than that in the control group，with significant difference (P<0.05). Conclusion FDP can effectively improve the treatment effect in children with VM，and significantly improve electrocardiogram and myocardial enzyme spectrum，it is worthy of clinical promotion and application.
[Key words] Fructose-1，6-diphosphate；Viral myocarditis in children； Ribavirin；Myocardial enzyme spectrum
病毒性心肌炎(viral myocarditis，VM)是常见的儿科疾病，主要由病毒感染人体后侵袭心肌引起弥漫性或局限性心肌组织炎症导致[1]。近年来，VM的发病率呈显著上升趋势，若延误治疗时间，可能会出现心源性休克、心律失常甚至心力衰竭等严重后果，威胁患儿生命[2]。目前，对于VM的治疗以抗病毒为主，辅以对症支持治疗，无临床特效药[3]。1，6-二磷酸果糖是一种治疗冠心病心绞痛、急性心肌梗死、心力衰竭和心律失常等的辅助药物[4]。本院将1，6-二磷酸果糖应用于VM的临床治疗，取得了较好的效果。
1 资料与方法
1.1 一般资料
选取2014年1月～2015年6月在本院接受治疗的30例VM患儿作为研究对象，随机分为观察组及对照组，各15例。所选患儿均有明显的VM症状，诊断均符合中华医学会儿科分会于2000年制订的VM诊断标准[5]。所有患儿家属均知情同意。观察组中，男8例，女7例；年龄4.3～16.7岁，平均(8.2±3.5)岁。对照组中，男7例，女8例；年龄4.2～16.9岁，平均(8.4±3.6)岁。两组的性别构成、平均年龄及病情程度等一般资料比较，差异无统计学意义(P>0.05)，具有可比性。
1.2 方法, 百拇医药(王智 蔡丽霞)
[关键词] 1，6-二磷酸果糖；小儿病毒性心肌炎；心肌酶谱
[中图分类号] R725.4 [文献标识码] A [文章编号] 1674-4721(2016)02(c)-0070-03
[Abstract] Objective To explore the effect of 1，6-diphosphate (FDP) in the treatment of children with viral myocarditis and its influence on myocardial enzyme spectrum. Methods 30 children patients with myocardial enzymes (VM) in our hospital from January 2014 to June 2015 were selected and randomly divided into the observation group and the control group，15 cases in each group.The control group was given conventional treatment，the observation group was treated with FDP on the basis of the control group.The treatment effect，the improvement condition of electrocardiogram and myocardial enzyme spectrum in the two groups was compared. Results The totally effective rate of the observation group was 93.33%，which was higher than 73.33% of the control group，with significant difference (P<0.05).The proportion of childrens whose electrocardiogram returned to normal in the observation group was 80.00%，which was higher than 53.33% in the control group，with significant difference (P<0.05).The level of myocardial enzyme after treatment in the observation group was lower than that in the control group，with significant difference (P<0.05). Conclusion FDP can effectively improve the treatment effect in children with VM，and significantly improve electrocardiogram and myocardial enzyme spectrum，it is worthy of clinical promotion and application.
[Key words] Fructose-1，6-diphosphate；Viral myocarditis in children； Ribavirin；Myocardial enzyme spectrum
病毒性心肌炎(viral myocarditis，VM)是常见的儿科疾病，主要由病毒感染人体后侵袭心肌引起弥漫性或局限性心肌组织炎症导致[1]。近年来，VM的发病率呈显著上升趋势，若延误治疗时间，可能会出现心源性休克、心律失常甚至心力衰竭等严重后果，威胁患儿生命[2]。目前，对于VM的治疗以抗病毒为主，辅以对症支持治疗，无临床特效药[3]。1，6-二磷酸果糖是一种治疗冠心病心绞痛、急性心肌梗死、心力衰竭和心律失常等的辅助药物[4]。本院将1，6-二磷酸果糖应用于VM的临床治疗，取得了较好的效果。
1 资料与方法
1.1 一般资料
选取2014年1月～2015年6月在本院接受治疗的30例VM患儿作为研究对象，随机分为观察组及对照组，各15例。所选患儿均有明显的VM症状，诊断均符合中华医学会儿科分会于2000年制订的VM诊断标准[5]。所有患儿家属均知情同意。观察组中，男8例，女7例；年龄4.3～16.7岁，平均(8.2±3.5)岁。对照组中，男7例，女8例；年龄4.2～16.9岁，平均(8.4±3.6)岁。两组的性别构成、平均年龄及病情程度等一般资料比较，差异无统计学意义(P>0.05)，具有可比性。
1.2 方法, 百拇医药(王智 蔡丽霞)