重复经颅磁治疗难治性精神分裂症的效果及对血清催乳素水平的影响(1)
[摘要] 目的 研究重复经颅磁(rTMS)治疗难治性精神分裂症效果及对血清催乳素(PRL)水平的影响。 方法 选取我院2014年1月～2015年6月接诊的120例精神分裂症患者作为研究对象，将其进行随机分组，每组60例。研究组患者给予高频rTMS刺激；对照组患者进行相应的假rTMS刺激，5次/周，连续进行2周。治疗前后测量两组患者的PANSS评分(阳性症状评分、阴性症状评分、一般病理评分、总分)、CGI-SI评分及血清PRL水平，调查治疗后两组患者的预后情况。 结果 治疗前，两组患者的PANSS评分、CGI-SI评分及血清PRL水平比较，差异无统计学意义(P>0.05)；治疗后，两组患者的PANSS评分、CGI-SI评分均有明显变化，差异有统计学意义(P<0.05)，且研究组患者的变化程度明显大于对照组，差异有统计学意义(P<0.05)；研究组患者的血清PRL水平明显降低，与治疗前比较，差异有统计学意义(P<0.05)，对照组患者变化不明显，与治疗前比较，差异无统计学意义(P>0.05)；治疗后研究组患者的血清PRL水平明显低于对照组(P<0.05)。治疗后，研究组患者的总有效率为56.7%，对照组为40.0%，两组比较差异有统计学意义(P<0.05)，研究组患者的显效率为35.0%，明显高于对照组的16.7%，差异有统计学意义(P<0.05)。 结论 rTMS治疗难治性精神分裂症具有一定疗效，可明显降低血清PRL水平，具有临床应用价值，值得推广。
[关键词] 经颅磁治疗；难治性精神分裂症；血清催乳素
[中图分类号] R749.3 [文献标识码] A [文章编号] 1674-4721(2016)03(c)-0054-04
[Abstract] Objective To study the effect analysis of transcranial magnetism therapy(rTMS) in the treatment of intractable schizophrenia and its influence on serum PRL level. Methods 120 patients with schizophrenia in our hospital from January 2014 to June 2015 were selected as research objects and were evenly divided into two groups in random.In research group，high-frequency rTMS was provided，while in control group，sham rTMS in the corresponding was applied.Five times per week for 2 consecutive weeks were needed.Score of positive and negative syndrome scale(PANSS)(positive symptom score，negative symptom score，pathological score，the total score)，CGI-SI score，and serum PRL level were tested before and after treatment between two groups.The prognosis after therapy was investigated between the two groups. Results Before treatment，there was no statistical difference in PANSS score，CGI-SI score or serum prolactin levels between the two groups(P>0.05).After therapy，the PANSS score and CGI-SI score between the two groups had obvious changes，the difference was statistically significant(P<0.05)，and the change degree of patients in the research group was significantly higher than that of the control group，the difference was statistically significant(P<0.05)；Serum PRL level in the research group was significantly decreased，which was displayed a statistical difference in comparison with that before treatment(P<0.05).No significant change was presented in the control group without statistical difference compared with prior treatment(P>0.05).The serum prolactin level after treatment in the research group was greatly lower than that in the control group(P<0.05).The total effective rate in the research group after therapy was 56.7%，and the rate in the control group was 40.0%，which was in a statistical difference(P<0.05)，the markedly effective rate in the research group was 35%，significantly higher than 16.7% in the control group(P<0.05). Conclusion rTMS can obtain some effect on treating intractable schizophrenia.It can remarkably decrease the level of serum prolactin and has clinical application value，which is worthy of promotion., 百拇医药(李一凡 张少霞 郑丽华 刘浩)
[关键词] 经颅磁治疗；难治性精神分裂症；血清催乳素
[中图分类号] R749.3 [文献标识码] A [文章编号] 1674-4721(2016)03(c)-0054-04
[Abstract] Objective To study the effect analysis of transcranial magnetism therapy(rTMS) in the treatment of intractable schizophrenia and its influence on serum PRL level. Methods 120 patients with schizophrenia in our hospital from January 2014 to June 2015 were selected as research objects and were evenly divided into two groups in random.In research group，high-frequency rTMS was provided，while in control group，sham rTMS in the corresponding was applied.Five times per week for 2 consecutive weeks were needed.Score of positive and negative syndrome scale(PANSS)(positive symptom score，negative symptom score，pathological score，the total score)，CGI-SI score，and serum PRL level were tested before and after treatment between two groups.The prognosis after therapy was investigated between the two groups. Results Before treatment，there was no statistical difference in PANSS score，CGI-SI score or serum prolactin levels between the two groups(P>0.05).After therapy，the PANSS score and CGI-SI score between the two groups had obvious changes，the difference was statistically significant(P<0.05)，and the change degree of patients in the research group was significantly higher than that of the control group，the difference was statistically significant(P<0.05)；Serum PRL level in the research group was significantly decreased，which was displayed a statistical difference in comparison with that before treatment(P<0.05).No significant change was presented in the control group without statistical difference compared with prior treatment(P>0.05).The serum prolactin level after treatment in the research group was greatly lower than that in the control group(P<0.05).The total effective rate in the research group after therapy was 56.7%，and the rate in the control group was 40.0%，which was in a statistical difference(P<0.05)，the markedly effective rate in the research group was 35%，significantly higher than 16.7% in the control group(P<0.05). Conclusion rTMS can obtain some effect on treating intractable schizophrenia.It can remarkably decrease the level of serum prolactin and has clinical application value，which is worthy of promotion., 百拇医药(李一凡 张少霞 郑丽华 刘浩)