[摘要] 目的 探讨七氟醚吸入麻醉与丙泊酚静脉麻醉对老年患者围术期的心肌保护作用。 方法 选择2014年3月～2015年3月于我院行食管癌根治术的老年患者40例，按随机数字表法将其分为七氟醚吸入麻醉组(S组)和丙泊酚静脉麻醉组(P组)，每组20例，比较两组患者不同时间点的血清心肌肌钙蛋I(cTnI)、microRNA-499、microRNA-208b水平。 结果 ①P组T2、T3、T4时刻的cTnI含量均高于S组，差异有统计学意义(P<0.05)；②P组T3时刻的microRNA-499和microRNA-208b含量均高于S组，差异有统计学意义(P<0.05)。 结论 七氟醚吸入麻醉较丙泊酚静脉麻醉更具心肌保护作用，对减少老年患者围术期心脏并发症有重要的意义。

    [关键词] 七氟醚；食管癌；心肌保护

    [中图分类号] R971+.2 [文献标识码] A [文章编号] 1674-4721(2016)05(b)-0093-03

    [Abstract] Objective To investigate the myocardial protective effect of sevoflurane inhalation anesthesia on perioperative period of elderly patients with propofol intravenous anesthesia. Methods 40 elderly patients who were given radical surgery for esophageal cancer in our hospital from March 2014 to March 2015 were selected.They were assigned to the group of inhalation anesthesia with sevoflurane (group S) and the group of intravenous anesthesia with propofol (group P) according to the random number table ......