艾灸对颈动脉粥样硬化斑块的影响研究(1)
[摘要] 目的 观察艾灸对颈动脉粥样硬化斑块的影响。 方法 选取我院2013年1月～2015年1月收治入院的颈动脉粥样斑块患者200例作为研究对象，随机将其分为治疗组和对照组，对照组100例给予口服阿托伐他汀+阿司匹林等常规临床治疗，治疗组100例患者在此基础上应用艾灸治疗，治疗6个月后，对两组患者的动脉粥样硬化斑块情况进行检测，包括斑块的大小、厚度及血管内中膜厚度等，并对两组患者治疗前后测定的胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)进行比较。 结果 两组患者在干预后，颈动脉粥样硬化斑块情况均有所改善，治疗组斑块大小、斑块厚度及血管内中膜厚度的减小程度均明显优于对照组，组间差异有统计学意义(P<0.05)；治疗6个月后，两组组内比较，TC、TG、LDL-C降低，HDL-C升高，差异有统计学意义(P<0.05)；两组间治疗后比较，治疗组TC、LDL-C、HDL-C优于对照组，差异有统计学意义(P<0.05)，TG比较差异无统计学意义(P>0.05)。 结论 艾灸可降低颈动脉粥样硬化斑块患者血脂水平，疗效显著。
[关键词] 艾灸；颈动脉粥样硬化；颈动脉内膜中层厚度
[中图分类号] R246 [文献标识码] A [文章编号] 1674-4721(2016)05(b)-0127-03
[Abstract] Objective To observe the influence of moxibustion on carotid atherosclerotic plaques. Methods 200 patients with carotid atherosclerotic plaques admitted from January 2013 to January 2015 into our hospital were selected as research objects，and they were evenly divided into treatment group and control group in random.In the control group，oral administration of atorvastatin and aspirin as conventional clinical treatment was provided，while in the treatment group，moxibustion was added on the basis of the control group.After 6-month treatment，the condition of carotid atherosclerotic plaques in the two groups were detected including the size and thickness of plaque，and intima-media thickness.Besides，the total cholesterol (TC)，triglyceride (TG)，high-density lipoprotein-C (HDL-C)，and low density lipoprotein-C (LDL-C) before and after treatment were compared. Results After interventions in both groups，the conditions of carotid atherosclerotic plaques were both improved.The reduction of the size and thickness of plaque，and intima-media thickness in the treatment group were all superior to those in the control group with statistical differences (P<0.05).After 6-month treatment，the levels of TC，TG，and LDL-C were decreased and HDL-C was increased within intra-group comparison with statistical differences (P<0.05).After comparison between the two groups，the levels of TC，HDL-C，and LDL-C were superior to those in the control group (P<0.05).There was no great difference in TG in both groups without statistical differences (P>0.05). Conclusion Moxibustion can obtain a remarkable effect on treating patients to reduce the blood lipid with carotid atherosclerotic plaques.
[Key words] Moxibustion；Carotid atherosclerosis；Intima-media thickness of carotid artery
颈动脉内膜增厚与颈动脉斑块是颈动脉粥样硬化，而颈动脉粥样硬化斑块则是机体发生缺血性脑血管疾病的主要危险因素之一[1]。医学影像检查是目前用于诊断颈动脉斑块的主要方法，他汀类药物可改善血管内皮功能、抗炎、抑制血小板聚集及血管平滑肌细胞增殖、迁移等，是临床常用治疗颈动脉斑块的药物[2-3]。颈动脉斑块属祖国中医理论中“痰凝”“血瘀”范畴[4]，患者多以脏腑亏虚为本，其中尤以肾虚为主，血络瘀阻、痰浊阻滞为标，以补肾、活血、清热、消斑为此病的治疗原则。我院根据多年临床诊治经验结合颈动脉斑块实际特征研制的针对性艾灸治疗，用于治疗颈动脉斑块患者可获得满意的效果及安全性，现报道如下。, 百拇医药(杨雨竹 王彩霞 周水香 高娟)
[关键词] 艾灸；颈动脉粥样硬化；颈动脉内膜中层厚度
[中图分类号] R246 [文献标识码] A [文章编号] 1674-4721(2016)05(b)-0127-03
[Abstract] Objective To observe the influence of moxibustion on carotid atherosclerotic plaques. Methods 200 patients with carotid atherosclerotic plaques admitted from January 2013 to January 2015 into our hospital were selected as research objects，and they were evenly divided into treatment group and control group in random.In the control group，oral administration of atorvastatin and aspirin as conventional clinical treatment was provided，while in the treatment group，moxibustion was added on the basis of the control group.After 6-month treatment，the condition of carotid atherosclerotic plaques in the two groups were detected including the size and thickness of plaque，and intima-media thickness.Besides，the total cholesterol (TC)，triglyceride (TG)，high-density lipoprotein-C (HDL-C)，and low density lipoprotein-C (LDL-C) before and after treatment were compared. Results After interventions in both groups，the conditions of carotid atherosclerotic plaques were both improved.The reduction of the size and thickness of plaque，and intima-media thickness in the treatment group were all superior to those in the control group with statistical differences (P<0.05).After 6-month treatment，the levels of TC，TG，and LDL-C were decreased and HDL-C was increased within intra-group comparison with statistical differences (P<0.05).After comparison between the two groups，the levels of TC，HDL-C，and LDL-C were superior to those in the control group (P<0.05).There was no great difference in TG in both groups without statistical differences (P>0.05). Conclusion Moxibustion can obtain a remarkable effect on treating patients to reduce the blood lipid with carotid atherosclerotic plaques.
[Key words] Moxibustion；Carotid atherosclerosis；Intima-media thickness of carotid artery
颈动脉内膜增厚与颈动脉斑块是颈动脉粥样硬化，而颈动脉粥样硬化斑块则是机体发生缺血性脑血管疾病的主要危险因素之一[1]。医学影像检查是目前用于诊断颈动脉斑块的主要方法，他汀类药物可改善血管内皮功能、抗炎、抑制血小板聚集及血管平滑肌细胞增殖、迁移等，是临床常用治疗颈动脉斑块的药物[2-3]。颈动脉斑块属祖国中医理论中“痰凝”“血瘀”范畴[4]，患者多以脏腑亏虚为本，其中尤以肾虚为主，血络瘀阻、痰浊阻滞为标，以补肾、活血、清热、消斑为此病的治疗原则。我院根据多年临床诊治经验结合颈动脉斑块实际特征研制的针对性艾灸治疗，用于治疗颈动脉斑块患者可获得满意的效果及安全性，现报道如下。, 百拇医药(杨雨竹 王彩霞 周水香 高娟)