右美托咪定复合盐酸羟考酮超前镇痛在胸腔镜短小手术中的应用效果(1)
[摘要] 目的 探讨右美托咪定复合盐酸羟考酮超前镇痛在胸腔镜短小手术中的应用效果。 方法 选择2014年11月～2015年11月我院择期进行胸腔镜手术患者60例，随机将其分为实验组和对照组。实验组在麻醉后切皮前给予右美托咪定1 μg/kg及盐酸羟考酮0.1 mg/kg缓慢静脉输注；对照组给予相应的生理盐水。分别记录麻醉诱导前(T0)、手术结束时(T1)、拔管时(T2)、拔管后30 min(T3)、拔管后2 h(T4)、拔管后4 h(T5)的血压、心率(HR)、脉氧饱和度及两组患者的呼吸恢复时间、睁眼时间、气管导管拔出时间、恶心呕吐等不良反应的发生率。评价患者于T3、T4、T5时的术后镇静评分(Ramsay)和视觉模拟评分(VAS)。 结果 两组患者在T0、T1时SBP、DBP、HR比较，差异无统计学意义(P>0.05)；实验组T2～T5时的SBP、DBP、HR明显降低，与对照组比较，差异有统计学意义(P<0.05)；实验组T3～T5时的VAS评分明显低于对照组，Ramsay评分高于对照组，差异有统计学意义(P<0.05)。结论 右美托咪定复合盐酸羟考酮超前镇痛在胸腔镜短小手术中可以减轻术后疼痛及躁动，循环稳定，并且没有增加恶心、呕吐等不良反应，值得推广应用。
[关键词] 右美托咪定；盐酸羟考酮；超前镇痛；胸腔镜手术
[中图分类号] R971 [文献标识码] A [文章编号] 1674-4721(2016)05(c)-0051-04
Application effect of Dexmedetomidine and Oxycodone Hydrochloride preventive analgesia in thoracoscope short operation
HAO Xiao-yan WANG Hui WANG Wei
Department of Anesthesiology，Dalian Friendship Hospital，Dalian 116001，China
[Abstract] Objective To explore the application effect of Dexmedetomidine and Oxycodone Hydrochloride preventive analgesia in thoracoscope short operation. Methods 60 patients，elective conducted thoracoscope surgery in our hospital，from November 2014 to November 2015 were selected and were random divided into two groups，experimental group and control group.Patients in experimental group were given Dexmedetomidine 1 μg/kg and Oxycodone Hydrochloride 0.1 mg/kg intravenous infusion slowly after anesthesia and before skin incision.Patients in control group were given correspondence saline.The blood pressure，heart rate，pulse oxygen saturation，breathing recovery time，eye opening time，pull out time of the endotracheal tube and the incidence rate of adverse effects liked nausea and vomiting at before anesthesia induction (T0)，end of the surgery (T1)，extubation (T2)，30 minutes after extubation (T3)，2 h after extubation (T4) and 4 h after extubation (T5) in two groups were respectively compared.The postoperative sedation scores (Ramsay) and visual analogue scale (VAS) at T3，T4 and T5 were evaluated. Results The SBP，DBP and HR of patients in two groups had no statistical significance (P>0.05)；from T2 to T5，SBP，DBP and HR in control group increased obviously，and had obvious difference with experimental group (P<0.05)；from T3 to T5，the VAS score in experimental group was obvious lower than that in control group，while Ramsay score was higher than that in control group，and the difference was obvious (P<0.05). Conclusion Dexmedetomidine and Oxycodone Hydrochloride preventive analgesia in thoracoscope short operation can alleviate postoperative pain and agitation，with stable circulation and not increase the incidence rate of adverse effects liked nausea and vomiting.It is worth to popularize and application., 百拇医药(郝晓燕 王辉 王玮)
[关键词] 右美托咪定；盐酸羟考酮；超前镇痛；胸腔镜手术
[中图分类号] R971 [文献标识码] A [文章编号] 1674-4721(2016)05(c)-0051-04
Application effect of Dexmedetomidine and Oxycodone Hydrochloride preventive analgesia in thoracoscope short operation
HAO Xiao-yan WANG Hui WANG Wei
Department of Anesthesiology，Dalian Friendship Hospital，Dalian 116001，China
[Abstract] Objective To explore the application effect of Dexmedetomidine and Oxycodone Hydrochloride preventive analgesia in thoracoscope short operation. Methods 60 patients，elective conducted thoracoscope surgery in our hospital，from November 2014 to November 2015 were selected and were random divided into two groups，experimental group and control group.Patients in experimental group were given Dexmedetomidine 1 μg/kg and Oxycodone Hydrochloride 0.1 mg/kg intravenous infusion slowly after anesthesia and before skin incision.Patients in control group were given correspondence saline.The blood pressure，heart rate，pulse oxygen saturation，breathing recovery time，eye opening time，pull out time of the endotracheal tube and the incidence rate of adverse effects liked nausea and vomiting at before anesthesia induction (T0)，end of the surgery (T1)，extubation (T2)，30 minutes after extubation (T3)，2 h after extubation (T4) and 4 h after extubation (T5) in two groups were respectively compared.The postoperative sedation scores (Ramsay) and visual analogue scale (VAS) at T3，T4 and T5 were evaluated. Results The SBP，DBP and HR of patients in two groups had no statistical significance (P>0.05)；from T2 to T5，SBP，DBP and HR in control group increased obviously，and had obvious difference with experimental group (P<0.05)；from T3 to T5，the VAS score in experimental group was obvious lower than that in control group，while Ramsay score was higher than that in control group，and the difference was obvious (P<0.05). Conclusion Dexmedetomidine and Oxycodone Hydrochloride preventive analgesia in thoracoscope short operation can alleviate postoperative pain and agitation，with stable circulation and not increase the incidence rate of adverse effects liked nausea and vomiting.It is worth to popularize and application., 百拇医药(郝晓燕 王辉 王玮)