丙戊酸对HL—60/HT细胞耐药性的影响(1)
[摘要]目的 探讨丙戊酸(VPA)对耐三尖杉酯碱的HL-60细胞(HL-60/HT)耐药性的影响。方法 选择递增压力培养法建立HL-60/HT细胞株。分为三组，Ara-C组、VPA组、VPA+Ara-C组，采用MTT法测定使用各组药物后敏感细胞、耐药细胞增殖情况的变化，同时测定丙戊酸对HL-60/HT细胞耐药性的改变，用流式细胞仪检测敏感的HL-60细胞及HL-60/HT细胞的细胞周期。结果 丙戊酸与Ara-C合用可明显抑制HL-60、HL-60/HT细胞生长，抑制率高于丙戊酸或Ara-C单独的作用(q=1.37、1.51)。結论 丙戊酸能够抑制HL-60、HL-60/HT细胞生长，可与Ara-C发挥协同作用，降低白血病细胞的耐药性。
[关键词]丙戊酸；HL-60/HT细胞；白血病
[中图分类号] R733.7 [文献标识码] A [文章编号] 1674-4721(2017)04(c)-0067-03
[Abstract]Objective To explore the impact of Valproic Acid (VPA) on drug resistance of HL-60 cells(HL-60/HT) resistant harringtonine.Methods HL-60/HT cell strain was established by incremental pressure culture and divided into 3 groups：Ara-C group ......
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[关键词]丙戊酸；HL-60/HT细胞；白血病
[中图分类号] R733.7 [文献标识码] A [文章编号] 1674-4721(2017)04(c)-0067-03
[Abstract]Objective To explore the impact of Valproic Acid (VPA) on drug resistance of HL-60 cells(HL-60/HT) resistant harringtonine.Methods HL-60/HT cell strain was established by incremental pressure culture and divided into 3 groups：Ara-C group ......
您现在查看是摘要页，全文长 3514 字符。