血清胱抑素C联合尿RBP检验在糖尿病患者早期肾损伤中的价值(1)
[摘要]目的 探讨糖尿病患者早期肾损伤血清胱抑素C(Cys C)联合尿视黄醇结合蛋白(RBP)检验的临床价值。方法 选取我院2015年6月～2016年6月的60例糖尿病早期肾损害患者作为观察组，联合检测所有患者的血清Cys C和尿RBP，与此同时选取同期于我院进行健康体检的60名健康人员作为对照组，测量其血清Cys C和尿RBP并进行对比，分析血清Cys C联合尿RBP检验对糖尿病患者早期肾损伤的临床诊断价值。结果 觀察组的血清Cys C和尿RBP水平显著高于对照组，差异有统计学意义(P<0.05)。血清Cys C联合尿RBP检测诊断糖尿病早期肾损伤的阳性检测率显著高于单独血清Cys C检测、尿RBP检测，差异有统计学意义(P<0.05)。结论 血清Cys C联合尿RBP检验能够为糖尿病患者早期肾损伤的诊断提供可靠的检验依据，值得临床推广应用。
[关键词]糖尿病；早期肾损伤；血清Cys C；尿RBP
[中图分类号] R587.1 [文献标识码] A [文章编号] 1674-4721(2017)06(c)-0109-03
[Abstract]Objective To explore the clinical value of the joint detection of serum cystatin C (Cys C) and urinary retinol binding protcin (RBP) in the diagnosis of early renal damage for diabetic patients.Methods 60 diabetic patients with early renal damage treated in our hospital from June 2015 and June 2016 were selected as the observation group，and they all underwent joint detection of serum Cys C and urinary RBP.Simultaneously，60 cases of the healthy people undergoing medical examination in our hospital were selected as the control group，and they all underwent joint detection of serum Cys C and urinary RBP.A comarison was made in serum Cys C and urinary RBP between the two groups to analyze the clinical value of in the diagnosis of early renal damage for diabetic patients.Results The levels of serum Cys C and urinary RBP test results of the observation group were significantly higher than those of the control group，and the difference was statistically significant (P<0.05).The positive rate of joint detection of serum Cys C and urinary RBP in the diagnosis of early renal injury in diabetes was significantly higher than that in single serum CysC test and urine RBP test，with significant difference (P<0.05).Conclusion The joint detection of serum Cys C and urinary RBP can provide reliable basis for the diagnosis of early renal damage for diabetic patients，and it is worthy of clinical promotion and application.
[Key words]Diabetes；Early renal injury；Serum Cys C；Urinary RBP
糖尿病是危害人类健康的一种常见病，以高并发症发生率为主要特点[1]。在其众多并发症中，以糖尿病肾病最为常见[2]。虽然糖尿病患者早期肾损伤可以治疗，但由于其发生、发展较为隐蔽，出现症状时已是中晚期，因此尽早诊断糖尿病早期肾损伤就显得尤为重要[3]。目前对于诊断糖尿病早期肾损伤普遍使用检测血清光抑素C(Cys C)或尿视黄醇结合蛋白(RBP)[4]，但两种方式均存在误诊或漏诊。有研究显示，血清Cys C联合尿RBP检验能够大幅度提高糖尿病患者早期肾损伤的临床诊断率[5]。为探讨Cys C联合尿RBP检验在糖尿病患者早期肾损伤诊断中的临床价值，本研究选取因糖尿病早期肾损害至我院肾脏科治疗的60例患者，给予血清Cys C联合尿RBP检验，分析其诊断价值，现将结果报道如下。
1资料与方法
1.1一般资料
根据WHO1999年制订的《糖尿病诊断标准》中糖尿病早期肾损伤的诊断标准，选取2015年6月～2016年6月因糖尿病早期肾损害至我院肾脏科治疗的60例患者作为观察组，其中男40例，女20例；年龄40～72岁，平均(53.4±10.5)岁；病程(5.3±4.8)年。所有患者对本次研究知情并签署同意书。排除标准：①糖尿病酮症酸中毒；②月经期、妊娠期及哺乳期妇女；③近期服用肾毒性药物；④尿路感染；⑤有其他严重疾病影响正常治疗和资料统计的患者。选取同期于我院进行健康体检的60名健康人员作为对照组，其中男性39例，女性21例；年龄38～76岁，平均(53.6±9.1)岁。两组的性别、年龄等一般资料比较，差异无统计学意义(P>0.05)，具有可比性。, 百拇医药(赖鑫)
[关键词]糖尿病；早期肾损伤；血清Cys C；尿RBP
[中图分类号] R587.1 [文献标识码] A [文章编号] 1674-4721(2017)06(c)-0109-03
[Abstract]Objective To explore the clinical value of the joint detection of serum cystatin C (Cys C) and urinary retinol binding protcin (RBP) in the diagnosis of early renal damage for diabetic patients.Methods 60 diabetic patients with early renal damage treated in our hospital from June 2015 and June 2016 were selected as the observation group，and they all underwent joint detection of serum Cys C and urinary RBP.Simultaneously，60 cases of the healthy people undergoing medical examination in our hospital were selected as the control group，and they all underwent joint detection of serum Cys C and urinary RBP.A comarison was made in serum Cys C and urinary RBP between the two groups to analyze the clinical value of in the diagnosis of early renal damage for diabetic patients.Results The levels of serum Cys C and urinary RBP test results of the observation group were significantly higher than those of the control group，and the difference was statistically significant (P<0.05).The positive rate of joint detection of serum Cys C and urinary RBP in the diagnosis of early renal injury in diabetes was significantly higher than that in single serum CysC test and urine RBP test，with significant difference (P<0.05).Conclusion The joint detection of serum Cys C and urinary RBP can provide reliable basis for the diagnosis of early renal damage for diabetic patients，and it is worthy of clinical promotion and application.
[Key words]Diabetes；Early renal injury；Serum Cys C；Urinary RBP
糖尿病是危害人类健康的一种常见病，以高并发症发生率为主要特点[1]。在其众多并发症中，以糖尿病肾病最为常见[2]。虽然糖尿病患者早期肾损伤可以治疗，但由于其发生、发展较为隐蔽，出现症状时已是中晚期，因此尽早诊断糖尿病早期肾损伤就显得尤为重要[3]。目前对于诊断糖尿病早期肾损伤普遍使用检测血清光抑素C(Cys C)或尿视黄醇结合蛋白(RBP)[4]，但两种方式均存在误诊或漏诊。有研究显示，血清Cys C联合尿RBP检验能够大幅度提高糖尿病患者早期肾损伤的临床诊断率[5]。为探讨Cys C联合尿RBP检验在糖尿病患者早期肾损伤诊断中的临床价值，本研究选取因糖尿病早期肾损害至我院肾脏科治疗的60例患者，给予血清Cys C联合尿RBP检验，分析其诊断价值，现将结果报道如下。
1资料与方法
1.1一般资料
根据WHO1999年制订的《糖尿病诊断标准》中糖尿病早期肾损伤的诊断标准，选取2015年6月～2016年6月因糖尿病早期肾损害至我院肾脏科治疗的60例患者作为观察组，其中男40例，女20例；年龄40～72岁，平均(53.4±10.5)岁；病程(5.3±4.8)年。所有患者对本次研究知情并签署同意书。排除标准：①糖尿病酮症酸中毒；②月经期、妊娠期及哺乳期妇女；③近期服用肾毒性药物；④尿路感染；⑤有其他严重疾病影响正常治疗和资料统计的患者。选取同期于我院进行健康体检的60名健康人员作为对照组，其中男性39例，女性21例；年龄38～76岁，平均(53.6±9.1)岁。两组的性别、年龄等一般资料比较，差异无统计学意义(P>0.05)，具有可比性。, 百拇医药(赖鑫)