小剂量米氮平联合度洛西汀治疗老年难治性抑郁症临床效果及安全性分析(1)
[摘要]目的 探討小剂量米氮平联合度洛西汀治疗老年难治性抑郁症临床效果及安全性。方法 选取2015年5月～2016年8月在我院收治的老年难治性抑郁症患者88例，根据随机数据表法分为观察组和对照组，每组44例，对照组患者给予度洛西汀治疗，观察组患者在对照基础上联合小剂量米氮平治疗，两组患者均治疗两个月。比较各组焦虑、抑郁程度评分，临床效果和不良反应。结果 观察组患者在治疗2周后、5周后、7周后的HAMA 评分、HAMD 评分及 CGI-SI 评分均显著低于对照组，差异有统计学意义(P<0.05)；观察组TESS评分为(1.78±0.36)分，与对照组(1.86±0.47)的评分比较，差异无统计学意义(P>0.05)。观察组不良反应发生率4.55%与对照组6.82%比较，差异无统计学意义(P>0.05)；观察组治疗总有效率(93.18%)明显高于对照组(72.72%)，差异有统计学意义(P<0.05)。结论 对老年难治性抑郁症患者，采取小剂量米氮平联合度洛西汀能取得较好的治疗效果，且不会增加不良反应发生率，值得推广。
[关键词]米氮平；度洛西汀；难治性抑郁症；安全性
[中图分类号] R749 [文献标识码] A [文章编号] 1674-4721(2017)11(c)-0075-03
Clinical effectand safety of low dose Mirtazapine combined with Duloxetine in the treatment of senile refractory depression
JIANG Shen-hui YE Qing
1.Department of Clinical Laboratory，the Fourth People′s Hospital of Jingdezhen City in Jiangxi Province，Jingdezhen 333000，China；2.Department of Psychiatic，the Fourth People′s Hospital of Jingdezhen City in Jiangxi Province，Jingdezhen 333000，China
[Abstract]Objective To investigate the clinical effect and safety of low dose Mirtazapine combined with Duloxetine in the treatment of senile refractory depression.Methods 88 elderly patients with refractory depression in our hospital during the period from May 2015 to August 2016 were selected，and randomly divided into two groups according to the random number table method，the observation group (44 cases) and control group (44 cases). The control group were treated with Duloxetine treatment，the observation group were treated with small dose of Mirtazapine on the basis of control group，patients of two group were treated for two months.The scores of anxiety and depression，the clinical effect and adverse reactions were compared.Results The scores of HAMA， HAMD and CGI-SI in the observation group were significantly lower than those in the control group after 2 weeks，5 weeks and 7 weeks，the difference was statistically significant (P<0.05).The TESS score of the observation group was (1.78±0.36) points， compared with the control group [(1.86±0.47)points]，there was no statistically significant difference (P>0.05).The incidence of adverse reactions in observation group was 4.55%，compared with the control group 6.82%，showed no significant difference (P>0.05).The total effective rate in the observation group was 93.18%， significantly higher than the control group(72.72%)，the difference was statistically significant (P<0.05).Conclusion For elderly refractory depression patients， the combination of low-dose Mirtazapine and Duloxetine can achieve better therapeutic effect， and will not increase the incidence of adverse drug reactions.It is worth popularizing., 百拇医药(江慎辉 叶青)
[关键词]米氮平；度洛西汀；难治性抑郁症；安全性
[中图分类号] R749 [文献标识码] A [文章编号] 1674-4721(2017)11(c)-0075-03
Clinical effectand safety of low dose Mirtazapine combined with Duloxetine in the treatment of senile refractory depression
JIANG Shen-hui YE Qing
1.Department of Clinical Laboratory，the Fourth People′s Hospital of Jingdezhen City in Jiangxi Province，Jingdezhen 333000，China；2.Department of Psychiatic，the Fourth People′s Hospital of Jingdezhen City in Jiangxi Province，Jingdezhen 333000，China
[Abstract]Objective To investigate the clinical effect and safety of low dose Mirtazapine combined with Duloxetine in the treatment of senile refractory depression.Methods 88 elderly patients with refractory depression in our hospital during the period from May 2015 to August 2016 were selected，and randomly divided into two groups according to the random number table method，the observation group (44 cases) and control group (44 cases). The control group were treated with Duloxetine treatment，the observation group were treated with small dose of Mirtazapine on the basis of control group，patients of two group were treated for two months.The scores of anxiety and depression，the clinical effect and adverse reactions were compared.Results The scores of HAMA， HAMD and CGI-SI in the observation group were significantly lower than those in the control group after 2 weeks，5 weeks and 7 weeks，the difference was statistically significant (P<0.05).The TESS score of the observation group was (1.78±0.36) points， compared with the control group [(1.86±0.47)points]，there was no statistically significant difference (P>0.05).The incidence of adverse reactions in observation group was 4.55%，compared with the control group 6.82%，showed no significant difference (P>0.05).The total effective rate in the observation group was 93.18%， significantly higher than the control group(72.72%)，the difference was statistically significant (P<0.05).Conclusion For elderly refractory depression patients， the combination of low-dose Mirtazapine and Duloxetine can achieve better therapeutic effect， and will not increase the incidence of adverse drug reactions.It is worth popularizing., 百拇医药(江慎辉 叶青)