八珍汤合化积丸加减结合肝动脉化疗栓塞术治疗原发性肝癌的临床效果观察(1)
[摘要]目的 探讨八珍汤合化积丸结合肝动脉化疗栓塞术治疗原发性肝癌的临床效果。方法 选取2015年11月7日～2016年12月3日我院收治的82例原发性肝癌患者，将其随机分为两组。对照组采取肝动脉化疗栓塞术，在此基础上，予以观察组八珍汤合化积丸。观察两组的临床效果、生活质量以及不良事件发生情况。结果 观察组的总缓解率为51.22%，明显高于对照组的24.39%(P<0.05)。观察组的心理、生理功能，社会关系、物质生活评分分别为(81.55±3.03)、(84.86±3.57)、(80.89±4.14)、(86.27±3.06)分，高于对照组的(76.19±3.26)、(72.71±2.79)、(71.79±3.28)、(75.79±4.11)分(P<0.05)。两组的不良事件发生率差异无统计学意义(P>0.05)。结论 八珍汤合化积丸联合肝动脉化疗栓塞术治疗原发性肝癌的临床价值高。
[关键词]原发性肝癌；肝动脉化疗栓塞术；八珍汤；化积丸
[中图分类号] R735.7 [文献标识码] A [文章编号] 1674-4721(2018)1(b)-0056-03
[Abstract]Objective To investigate the clinical effect of Bazhen Decoction and Huaji Pills combined with hepatic arterial chemoembolization operation in the treatment of primary liver cancer.Methods From November 7，2015 to December 3，2016，82 patients with primary liver cancer were selected and they were randomly divided into two groups.The control group was treated with transcatheter arterial chemoembolization.On this basis，the observation group was treated with Bazhen Decoction and Huaji Pills.The clinical effect，quality of life and the incidence of adverse events were observed in the two groups.Results The total remission rate of the observation group was 51.22%，which was significantly higher than that of the control group (24.39%) (P<0.05).Psychological，physiological function，social relationship，material life score in the observation group was (81.55±3.03)，(84.86±3.57)， (80.89±4.14)，(86.27±3.06) points respectively，which was higher than that of the control group ([76.19±3.26]，[72.71±2.79]，[71.79±3.28]，[75.79±4.11] points) (P<0.05).There was no significant difference in the incidence of adverse events between the two groups (P>0.05).Conclusion The clinical value of Bazhen Decoction and Huaji Pills combined with hepatic arterial chemoembolization operation in the treatment of primary liver cancer is high.
[Key words]Primary liver cancer；Hepatic arterial chemoembolization operation；Bazhen Decoction；Huaji Pills
原發性肝癌作为常见恶性疾病，病情发展较快，死亡风险高，患者通常生存期较短，预后不佳。此疾病早期无特异性表现[1-3]，诊断难度较大，就诊时通常已为中晚期，早期手术治疗可有效控制病情，中晚期则使用肝动脉化疗栓塞术治疗[4-6]，但通常无法获得理想效果。本文旨在探讨八珍汤合化积丸加减结合肝动脉化疗栓塞术治疗原发性肝癌的临床效果。
1资料与方法
1.1一般资料
选取2015年11月7日～2016年12月3日于我院就诊的82例原发性肝癌患者进行研究，采取随机分组法，每组41例。对照组男女之比为27∶14；病程为(2.04±0.71)年；年龄为(49.68±4.21)岁。观察组男女之比为29∶12；病程为(2.19±0.95)年；年龄为(49.93±4.42)岁。本研究已经医学伦理委员会批准。纳入标准：经CT、临床表现等检查确诊者；年龄≥35岁；手术耐受者；生存期预计>3个月者；积极配合研究者。排除标准：肝肾功能严重损害者；药物禁忌或手术不耐受者；其他系统或脏器严重疾病者；严重合并症者。两组患者的一般资料差异无统计学意义(P>0.05)，具有可比性。
1.2方法
对照组实施肝动脉化疗栓塞术，常规肝动脉造影，将药物(80～100 mg顺铂、40～60 mg阿霉素以及1 g氟尿嘧啶)灌注于肝内动脉，实施肝内动脉栓塞术，使用10～20 ml碘化油(超乳化)[7-9]，治疗时间为2个月。, http://www.100md.com(石洪伟 许斌 林彬)
[关键词]原发性肝癌；肝动脉化疗栓塞术；八珍汤；化积丸
[中图分类号] R735.7 [文献标识码] A [文章编号] 1674-4721(2018)1(b)-0056-03
[Abstract]Objective To investigate the clinical effect of Bazhen Decoction and Huaji Pills combined with hepatic arterial chemoembolization operation in the treatment of primary liver cancer.Methods From November 7，2015 to December 3，2016，82 patients with primary liver cancer were selected and they were randomly divided into two groups.The control group was treated with transcatheter arterial chemoembolization.On this basis，the observation group was treated with Bazhen Decoction and Huaji Pills.The clinical effect，quality of life and the incidence of adverse events were observed in the two groups.Results The total remission rate of the observation group was 51.22%，which was significantly higher than that of the control group (24.39%) (P<0.05).Psychological，physiological function，social relationship，material life score in the observation group was (81.55±3.03)，(84.86±3.57)， (80.89±4.14)，(86.27±3.06) points respectively，which was higher than that of the control group ([76.19±3.26]，[72.71±2.79]，[71.79±3.28]，[75.79±4.11] points) (P<0.05).There was no significant difference in the incidence of adverse events between the two groups (P>0.05).Conclusion The clinical value of Bazhen Decoction and Huaji Pills combined with hepatic arterial chemoembolization operation in the treatment of primary liver cancer is high.
[Key words]Primary liver cancer；Hepatic arterial chemoembolization operation；Bazhen Decoction；Huaji Pills
原發性肝癌作为常见恶性疾病，病情发展较快，死亡风险高，患者通常生存期较短，预后不佳。此疾病早期无特异性表现[1-3]，诊断难度较大，就诊时通常已为中晚期，早期手术治疗可有效控制病情，中晚期则使用肝动脉化疗栓塞术治疗[4-6]，但通常无法获得理想效果。本文旨在探讨八珍汤合化积丸加减结合肝动脉化疗栓塞术治疗原发性肝癌的临床效果。
1资料与方法
1.1一般资料
选取2015年11月7日～2016年12月3日于我院就诊的82例原发性肝癌患者进行研究，采取随机分组法，每组41例。对照组男女之比为27∶14；病程为(2.04±0.71)年；年龄为(49.68±4.21)岁。观察组男女之比为29∶12；病程为(2.19±0.95)年；年龄为(49.93±4.42)岁。本研究已经医学伦理委员会批准。纳入标准：经CT、临床表现等检查确诊者；年龄≥35岁；手术耐受者；生存期预计>3个月者；积极配合研究者。排除标准：肝肾功能严重损害者；药物禁忌或手术不耐受者；其他系统或脏器严重疾病者；严重合并症者。两组患者的一般资料差异无统计学意义(P>0.05)，具有可比性。
1.2方法
对照组实施肝动脉化疗栓塞术，常规肝动脉造影，将药物(80～100 mg顺铂、40～60 mg阿霉素以及1 g氟尿嘧啶)灌注于肝内动脉，实施肝内动脉栓塞术，使用10～20 ml碘化油(超乳化)[7-9]，治疗时间为2个月。, http://www.100md.com(石洪伟 许斌 林彬)