他汀强化治疗方案在急性脑梗死患者中的应用效果(1)
[摘要]目的 探討他汀强化治疗方案在急性脑梗死患者中的应用效果。方法 选取2016年1月～2018年1月在我院神经内科治疗的120例急性脑梗死患者作为研究对象，按照数字分组法将其分为两组。两组患者均给予常规药物治疗，对照组患者在此基础上采用阿托伐他汀钙(20 mg/d)治疗，观察组患者采用阿托伐他汀钙(40 mg/d)治疗。比较两组患者的临床疗效、治疗前后神经功能变化、血脂及C反应蛋白(CRP)水平变化、安全性。结果 观察组患者的治疗总有效率为91.67%，明显高于对照组的76.67%，差异有统计学意义(P<0.05)。观察组患者治疗后的美国国立卫生院神经功能缺损评分量表(NIHSS)、改良Rankin量表评分明显低于对照组，而日常生活功能量表(ADL)评分明显高于对照组，差异有统计学意义(P<0.05)。观察组患者治疗后的总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、CRP明显低于对照组，高密度脂蛋白胆固醇(HDL-C)明显高于对照组，差异有统计学意义(P<0.05)。观察组患者消化道不适、失眠、一过性小腿肌痛等不良反应发生率与对照组比较，差异无统计学意义(P>0.05)。结论 他汀强化治疗方案在急性脑梗死患者中的应用效果显著，能降低致死率及致残率，提高生活质量，同时不明显增加他汀类药物的不良反应，具有积极的临床意义。
[关键词]急性脑梗死；他汀强化治疗方案；临床疗效；药物安全性
[中图分类号] R541.4 [文献标识码] A [文章编号] 1674-4721(2018)10(a)-0066-04
[Abstract] Objective To investigate the application effect of Statin intensive treatment regimen in the patients with acute cerebral infarction. Methods A total of 120 patients with acute cerebral infarction who were treated in the department of neurology in our hospital from January 2016 to February 2018 were selected as subjects and were divided into two groups according to the number grouping method. All patients were given conventional medication. On this basis， the control group was given Atorvastatin Calcium of 20 mg/d for treatment. The observation group was given Atorvastatin Calcium of 40 mg/d for treatment.The clinical efficacy， changes in neurological function before and after treatment， changes in blood lipids and C-reactive protein (CRP) levels， and safety were compared between the two groups. Results The total effective rate in the observation group was 91.67%， which was significantly higher than that of 76.67% in the control group， the difference was statistically significant (P<0.05). The National Institutes of Health Stroke Scale (NIHSS) and the modified Rankin Scale score after treatment in the observation group were significantly lower than in the control group， the differences were statistically significant (P<0.05). Activities of daily living (ADL) score in the observation group was significantly higher than that in the control group， and the differences were statistically significant (P<0.05). The total cholesterol (TC)， triglyceride (TG)， low-density lipoprotein cholesterol (LDL-C) and CRP in the observation group after treatment were significantly lower than those in the control group， high-density lipoprotein cholesterol (HDL-C) in the observation group was significantly higher than those in the control group， the differences were statistically significant (P<0.05). There were no significant differences in incidence of adverse drug reactions， such as digestive discomfort， insomnia， and transient calf muscle pain， which in the observation group compared with the control group (P>0.05). Conclusion The statin intensive treatment regimen has a significant effect in patients with acute cerebral infarction， which can reduce the mortality rate and disability rate and improve the quality of life. At the same time， it does not significantly increase the adverse reactions of statins， and has a positive clinical significance., 百拇医药(黄伟东 李亮 梁仕泮)
[关键词]急性脑梗死；他汀强化治疗方案；临床疗效；药物安全性
[中图分类号] R541.4 [文献标识码] A [文章编号] 1674-4721(2018)10(a)-0066-04
[Abstract] Objective To investigate the application effect of Statin intensive treatment regimen in the patients with acute cerebral infarction. Methods A total of 120 patients with acute cerebral infarction who were treated in the department of neurology in our hospital from January 2016 to February 2018 were selected as subjects and were divided into two groups according to the number grouping method. All patients were given conventional medication. On this basis， the control group was given Atorvastatin Calcium of 20 mg/d for treatment. The observation group was given Atorvastatin Calcium of 40 mg/d for treatment.The clinical efficacy， changes in neurological function before and after treatment， changes in blood lipids and C-reactive protein (CRP) levels， and safety were compared between the two groups. Results The total effective rate in the observation group was 91.67%， which was significantly higher than that of 76.67% in the control group， the difference was statistically significant (P<0.05). The National Institutes of Health Stroke Scale (NIHSS) and the modified Rankin Scale score after treatment in the observation group were significantly lower than in the control group， the differences were statistically significant (P<0.05). Activities of daily living (ADL) score in the observation group was significantly higher than that in the control group， and the differences were statistically significant (P<0.05). The total cholesterol (TC)， triglyceride (TG)， low-density lipoprotein cholesterol (LDL-C) and CRP in the observation group after treatment were significantly lower than those in the control group， high-density lipoprotein cholesterol (HDL-C) in the observation group was significantly higher than those in the control group， the differences were statistically significant (P<0.05). There were no significant differences in incidence of adverse drug reactions， such as digestive discomfort， insomnia， and transient calf muscle pain， which in the observation group compared with the control group (P>0.05). Conclusion The statin intensive treatment regimen has a significant effect in patients with acute cerebral infarction， which can reduce the mortality rate and disability rate and improve the quality of life. At the same time， it does not significantly increase the adverse reactions of statins， and has a positive clinical significance., 百拇医药(黄伟东 李亮 梁仕泮)