白介素—8、C反应蛋白在儿童阻塞性睡眠呼吸暂停低通气综合征中的临床意义(1)
[摘要]目的 探讨白介素-8(IL-8)和C反应蛋白(CRP)在儿童阻塞性睡眠呼吸暂停低通气综合征(OSAHS)中的临床意义。方法 选取2017年3月～2018年3月在我院就诊的80例OSAHS患儿，根据OSAHS病情分为轻、中、重度三组。同时选取60例健康儿童作对照组。检测儿童血清中IL-8和CRP水平，分析其与OSAHS发病情况的关系。结果 轻、中、重度组患儿血清IL-8水平均显著高于对照组；且随着OSAHS程度的加重，血清IL-8水平显著增高，差异均有统计学意义(P<0.05)。中、重度组患儿CRP水平显著高于轻度组及对照组，且重度组患儿血清CRP水平显著高于中度组，差异均有统计学意义(P<0.05)。结论 儿童OSAHS血清IL-8及CRP水平均有显著变化，且随着病情加重而明显增高。
[关键词]阻塞性睡眠呼吸暂停低通气综合征；白介素-8；C反应蛋白
[中图分类号] R766 [文献标识码] A [文章编号] 1674-4721(2018)12(b)-0101-03
[Abstract] Objective To investigate the clinical significance of IL-8 and CRP in children with obstructive sleep apnea hypopnea syndrome(OSAHS). Methods 80 children with OSAHS in our hospital from March 2017 to March 2018 were selected and divided into light， moderate and severe three groups according to OSAHS condition. At the same time， 60 healthy children were selected as the control group. The levels of IL-8 and CRP of children were detected， and the relationship with the occurrence of OSAHS was analyzed. Results The level of IL-8 in light， moderate， severe group was significantly higher than that of the control group， and the level of IL-8 was increased with the aggravation of OSAHS (P<0.05). The level of CRP in the moderate and severe group was significantly higher than that of light group and control group， and the level of the severe group was significantly higher than that in the moderate group， the differences were statistically significant (P<0.05). Conclusion There are changes of serum IL-8 and CRP levels in children with OSAHS， and it increases significantly with the aggravation of OSAHS.
[Key words] Obstructive sleep apnea hypopnea syndrome； Interleukin-8； C reactive protein
阻塞性睡眠呼吸暫停低通气综合征(OSAHS)作为一种睡眠障碍，在影响睡眠的同时可能对机体其他系统造成影响，可引起缺氧、二氧化碳潴留及高血压等疾病[1-2]。OSAHS在处于发育阶段的儿童期发病率为1%～3%，对儿童生长的影响可能是潜在和多方面的[3]。因此，明确儿童OSAHS对体格智力发育的影响及诊断标志物，有很重要的临床价值。
研究表明，儿童OSAHS最常见原因是腺样体肥大，且常伴发机体一系列的炎症反应，临床实验室指标多表现为细胞因子及炎性水平改变[4]。此外，OSAHS能影响神经系统在睡眠过程中的内分泌水平，同时可能对免疫系统带来一定影响[5]。白介素8(IL-8)是机体一类重要的炎性因子，推测IL-8可能参与OSAHS的疾病进程；而C反应蛋白(CRP)作为反映炎症水平的重要指标，可能也与OSAHS病情存在相关性[6]。本研究拟通过比较儿童OSAHS和正常儿童血清IL-8和CRP水平，以明确IL-8和CRP水平两者在儿童OSAHS诊断与治疗中的临床意义。
1资料与方法
1.1一般资料
选取2017年3月～2018年3月在我院就诊的OSAHS 80例患儿，男39例，女41例；年龄6岁1个月～9岁1个月，平均(7.45±0.25)岁。根据OSAHS病情分为轻度组(28例)、中度组(29例)及重度组(23例)。同时选取儿童保健科体检的各60例健康男女童，年龄6岁1个月～8岁11个月，平均(7.39±0.50)岁为对照组。本研究经医院医学伦理委员会批准，且征得家长和儿童同意。两组的年龄、性别等一般资料比较，差异无统计学意义(P>0.05)，具有可比性。
1.2多导睡眠脑电图分析儿童睡眠
在睡眠监测室用多导睡眠脑电图(PSG)对儿童睡眠质量进行监测，监测时长>7 h。儿童均由家长陪护，并由专业人员进行指导监控。全程记录儿童睡眠过程中阻塞性呼吸暂停指数(OAI)、呼吸暂停低通气指数(AHI)以及最低动脉血氧饱和度(SaO2)。, 百拇医药(谢丹)
[关键词]阻塞性睡眠呼吸暂停低通气综合征；白介素-8；C反应蛋白
[中图分类号] R766 [文献标识码] A [文章编号] 1674-4721(2018)12(b)-0101-03
[Abstract] Objective To investigate the clinical significance of IL-8 and CRP in children with obstructive sleep apnea hypopnea syndrome(OSAHS). Methods 80 children with OSAHS in our hospital from March 2017 to March 2018 were selected and divided into light， moderate and severe three groups according to OSAHS condition. At the same time， 60 healthy children were selected as the control group. The levels of IL-8 and CRP of children were detected， and the relationship with the occurrence of OSAHS was analyzed. Results The level of IL-8 in light， moderate， severe group was significantly higher than that of the control group， and the level of IL-8 was increased with the aggravation of OSAHS (P<0.05). The level of CRP in the moderate and severe group was significantly higher than that of light group and control group， and the level of the severe group was significantly higher than that in the moderate group， the differences were statistically significant (P<0.05). Conclusion There are changes of serum IL-8 and CRP levels in children with OSAHS， and it increases significantly with the aggravation of OSAHS.
[Key words] Obstructive sleep apnea hypopnea syndrome； Interleukin-8； C reactive protein
阻塞性睡眠呼吸暫停低通气综合征(OSAHS)作为一种睡眠障碍，在影响睡眠的同时可能对机体其他系统造成影响，可引起缺氧、二氧化碳潴留及高血压等疾病[1-2]。OSAHS在处于发育阶段的儿童期发病率为1%～3%，对儿童生长的影响可能是潜在和多方面的[3]。因此，明确儿童OSAHS对体格智力发育的影响及诊断标志物，有很重要的临床价值。
研究表明，儿童OSAHS最常见原因是腺样体肥大，且常伴发机体一系列的炎症反应，临床实验室指标多表现为细胞因子及炎性水平改变[4]。此外，OSAHS能影响神经系统在睡眠过程中的内分泌水平，同时可能对免疫系统带来一定影响[5]。白介素8(IL-8)是机体一类重要的炎性因子，推测IL-8可能参与OSAHS的疾病进程；而C反应蛋白(CRP)作为反映炎症水平的重要指标，可能也与OSAHS病情存在相关性[6]。本研究拟通过比较儿童OSAHS和正常儿童血清IL-8和CRP水平，以明确IL-8和CRP水平两者在儿童OSAHS诊断与治疗中的临床意义。
1资料与方法
1.1一般资料
选取2017年3月～2018年3月在我院就诊的OSAHS 80例患儿，男39例，女41例；年龄6岁1个月～9岁1个月，平均(7.45±0.25)岁。根据OSAHS病情分为轻度组(28例)、中度组(29例)及重度组(23例)。同时选取儿童保健科体检的各60例健康男女童，年龄6岁1个月～8岁11个月，平均(7.39±0.50)岁为对照组。本研究经医院医学伦理委员会批准，且征得家长和儿童同意。两组的年龄、性别等一般资料比较，差异无统计学意义(P>0.05)，具有可比性。
1.2多导睡眠脑电图分析儿童睡眠
在睡眠监测室用多导睡眠脑电图(PSG)对儿童睡眠质量进行监测，监测时长>7 h。儿童均由家长陪护，并由专业人员进行指导监控。全程记录儿童睡眠过程中阻塞性呼吸暂停指数(OAI)、呼吸暂停低通气指数(AHI)以及最低动脉血氧饱和度(SaO2)。, 百拇医药(谢丹)