[摘要]抑癌基因PTEN具有双重特异性磷酸酶活性，其表达缺失可见于多种散发性肿瘤。PTEN基因主要通过对过磷脂酰肌醇3激酶(Pl3K)/蛋白激酶B(AKT)和丝裂原激活蛋白激酶(MAPK)等信号通路平衡的调节发挥抑癌机制。转录前(如基因突变、甲基化、表达缺失)以及转录水平和转录后的调控是PTEN基因表达的重要影响因素。本文就PTEN基因结构、生物学功能、与信号通路作用機制及其调控的研究进展作一综述。

    [关键词]PTEN；基因；肿瘤；进展

    [中图分类号] R737.2 [文献标识码] A [文章编号] 1674-4721(2019)5(a)-0019-04

    [Abstract] The tumor suppressor gene PTEN has dual specific phosphatase activity， and its expression loss can be found in a variety of sporadic tumors. The PTEN gene acts as a tumor suppressor by regulating the balance of signaling pathways such as phosphatidylinositol 3 kinase (Pl3K) /protein kinase B (AKT) and mitogen activated protein kinase (MAPK). The regulation and control on pre-transcription (such as gene mutation ......