超声引导下微通道经皮肾镜取石术对上尿路结石患者围术期炎性应激指标的影响(1)
[摘要]目的 觀察超声引导下微通道经皮肾镜取石术对上尿路结石患者围术期炎性应激指标的影响。方法 选取2016年6月～2018年6月我院诊治的110例上尿路结石患者作为研究对象，根据手术方式的不同将其分为对照组(55例)和观察组(55例)。对照组患者给予常规手术治疗，观察组患者给予超声引导下微通道经皮肾镜取石术治疗。比较两组患者治疗前、治疗后1、3 d的围术期抗炎指标[白介素-4(IL-4)、白介素-10(IL-10)、白介素-13(IL-13)]、促炎指标[白介素-1β(IL-1β)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]及应激激素指标[皮质醇(Cor)、血管紧张素-Ⅱ(Ang-Ⅱ)、醛固酮(ALD)]水平。结果 两组患者治疗前的抗炎指标、促炎指标及应激激素指标水平比较，差异无统计学意义(P>0.05)；两组患者治疗后1、3 d的抗炎指标、促炎指标及应激激素指标水平均先上升后下降，差异有统计学意义(P<0.05)；观察组患者治疗后1、3 d的抗炎指标、促炎指标及应激激素指标水平均低于对照组，差异有统计学意义(P<0.05)。结论 超声引导下微通道经皮肾镜取石术治疗的患者围术期炎性应激指标波动幅度较小，不良应激控制效果相对更好。
[关键词]超声引导下微通道经皮肾镜取石术；围术期；抗炎指标；促炎指标；应激激素
[中图分类号] R000 [文献标识码] A [文章编号] 1674-4721(2019)5(a)-0113-04
Effect of ultrasound-guided microchannel percutaneous nephrolithotomy on perioperative inflammatory stress index in patients with upper urinary calculi
LYU Wang-hua
Department of Urinary Surgery， Central People′s Hospital of Zhanjiang， Guangdong Province， Zhanjiang 524000， China
[Abstract] Objective To observe the effect of ultrasound-guided microchannel percutaneous nephrolithotomy on perioperative inflammatory stress index in patients with upper urinary calculi. Methods A total of 110 patients with upper urinary calculi diagnosed and treated in our hospital from June 2016 to June 2018 were selected as the study subjects. They were divided into control group (55 cases) and observation group (55 cases) according to different surgical methods. Patients in the control group were treated with conventional surgery， and the patients in the observation group were treated with ultrasound-guided microchannel percutaneous nephrolithotomy. The levels of perioperative anti-inflammatory indicators (interleukin-4 [IL-4]， interleukin-10 [IL-10]， interleukin-13 [IL-13])， pro-inflammatory indicators (interleukin-1β [IL-1β]， interleukin-6 [IL-6]， tumor necrosis factor-α [TNF-α]) and stress hormone indicators (cortisol [Cor]， angiotensin-Ⅱ [Ang-Ⅱ]， aldosterone [ALD]) were compared between the two groups before treatment and 1， 3 days after treatment. Results There were no significant differences in the levels of anti-inflammatory index， pro-inflammatory index and stress hormone index between the two groups before treatment (P>0.05). The levels of anti-inflammatory index， pro-inflammatory index and stress hormone index of the two groups increased first and then decreased at 1 and 3 days after treatment， with statistically significant differences (P<0.05). The levels of anti-inflammatory index， pro-inflammatory index and stress hormone index of the observation group were lower than those of the control group at 1 and 3 days after treatment， and the differences were statistically significant (P<0.05). Conclusion The fluctuation range of perioperative inflammatory stress index of patients treated with ultrasound-guided percutaneous nephrolithotomy is smaller， and the control effect of adverse stress is relatively better., 百拇医药(吕王华)
[关键词]超声引导下微通道经皮肾镜取石术；围术期；抗炎指标；促炎指标；应激激素
[中图分类号] R000 [文献标识码] A [文章编号] 1674-4721(2019)5(a)-0113-04
Effect of ultrasound-guided microchannel percutaneous nephrolithotomy on perioperative inflammatory stress index in patients with upper urinary calculi
LYU Wang-hua
Department of Urinary Surgery， Central People′s Hospital of Zhanjiang， Guangdong Province， Zhanjiang 524000， China
[Abstract] Objective To observe the effect of ultrasound-guided microchannel percutaneous nephrolithotomy on perioperative inflammatory stress index in patients with upper urinary calculi. Methods A total of 110 patients with upper urinary calculi diagnosed and treated in our hospital from June 2016 to June 2018 were selected as the study subjects. They were divided into control group (55 cases) and observation group (55 cases) according to different surgical methods. Patients in the control group were treated with conventional surgery， and the patients in the observation group were treated with ultrasound-guided microchannel percutaneous nephrolithotomy. The levels of perioperative anti-inflammatory indicators (interleukin-4 [IL-4]， interleukin-10 [IL-10]， interleukin-13 [IL-13])， pro-inflammatory indicators (interleukin-1β [IL-1β]， interleukin-6 [IL-6]， tumor necrosis factor-α [TNF-α]) and stress hormone indicators (cortisol [Cor]， angiotensin-Ⅱ [Ang-Ⅱ]， aldosterone [ALD]) were compared between the two groups before treatment and 1， 3 days after treatment. Results There were no significant differences in the levels of anti-inflammatory index， pro-inflammatory index and stress hormone index between the two groups before treatment (P>0.05). The levels of anti-inflammatory index， pro-inflammatory index and stress hormone index of the two groups increased first and then decreased at 1 and 3 days after treatment， with statistically significant differences (P<0.05). The levels of anti-inflammatory index， pro-inflammatory index and stress hormone index of the observation group were lower than those of the control group at 1 and 3 days after treatment， and the differences were statistically significant (P<0.05). Conclusion The fluctuation range of perioperative inflammatory stress index of patients treated with ultrasound-guided percutaneous nephrolithotomy is smaller， and the control effect of adverse stress is relatively better., 百拇医药(吕王华)