低分子肝素辅助治疗复发性流产的临床效果及对免疫功能、激素水平的影响(1)
[摘要]目的 探討低分子肝素辅助传统安胎法治疗复发性流产患者的临床效果及对其免疫功能、激素水平的影响。方法 选取我院2016年2月～2017年3月收治的204例复发性流产患者作为研究对象，按照随机数字表法分为对照组(102例)与研究组(102例)。对照组采用传统安胎法治疗，研究组在对照组的基础上采用低分子肝素辅助治疗。比较两组患者的妊娠结局、血清雌二醇(E2)、绒毛膜促性腺激素(HCG)、孕酮(P)、白细胞介素-4(IL-4)、γ-干扰素(IFN-γ)、IFN-γ/IL-4水平以及不良反应发生情况。结果 研究组的保胎成功率为88.24%，高于对照组的59.80%，差异有统计学意义(P<0.05)。研究组干预后的IFN-γ、IFN-γ/IL-4水平低于对照组，差异有统计学意义(P<0.05)。研究组干预后的IL-4、HCG、P、E2水平高于对照组，差异有统计学意义(P<0.05)。两组的不良反应发生率比较，差异无统计学意义(P>0.05)。结论 复发性流产采用传统安胎法联合低分子肝素治疗可显著提高保胎成功率，能够改善机体激素水平与免疫功能，并且不良反应发生率较低。
[关键词]低分子肝素;复发性流产;免疫功能;激素
[中图分类号] R714.21 [文献标识码] A [文章编号] 1674-4721(2019)6(a)-0145-03
[Abstract] Objective To explore the clinical effects of Low Molecular Weight Heparin combined with traditional placenta therapy in the treatment of patients with recurrent spontaneous abortion and its influence on immune function and hormone levels. Methods A total of 204 patients with recurrent spontaneous abortion who admitted to our hospital from February 2016 to March 2017 were selected as the research objects. According to the random number table method， the patients were divided into the control group (102 cases) and the study group (102 cases). The control group was treated with traditional placenta therapy， while the study group was treated with Low Molecular Weight Heparin as adjuvant therapy on the basis of the control group. Pregnancy outcomes， the level of serum estradiol (E2)， human chorionic gonadotropin (HCG)， progesterone (P)， interleukin-4 (IL-4)， interferon-γ (IFN-γ)， IFN-gamma/IL-4 and adverse reactions were compared between the two groups. Results The success rate of fetal protection in the study group was 88.24%， which was higher than that in the control group (59.80%)， and the difference was statistically significant (P<0.05). The level of IFN-γ and IFN-γ/IL-4 in the study group after intervention were lower than those in the control group， and the difference was statistically significant (P<0.05). The levels of IL-4， HCG， P， and E2 in the study group after intervention were higher than those in the control group， the difference was statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Recurrent abortion with traditional placenta therapy combined with Low Molecular Weight Heparin treatment can significantly improve the success rate of fetal protection， improve the body hormone level and immune function， and the incidence of adverse reactions is low., http://www.100md.com(林志金 杨秀珍 张炯兰)
[关键词]低分子肝素;复发性流产;免疫功能;激素
[中图分类号] R714.21 [文献标识码] A [文章编号] 1674-4721(2019)6(a)-0145-03
[Abstract] Objective To explore the clinical effects of Low Molecular Weight Heparin combined with traditional placenta therapy in the treatment of patients with recurrent spontaneous abortion and its influence on immune function and hormone levels. Methods A total of 204 patients with recurrent spontaneous abortion who admitted to our hospital from February 2016 to March 2017 were selected as the research objects. According to the random number table method， the patients were divided into the control group (102 cases) and the study group (102 cases). The control group was treated with traditional placenta therapy， while the study group was treated with Low Molecular Weight Heparin as adjuvant therapy on the basis of the control group. Pregnancy outcomes， the level of serum estradiol (E2)， human chorionic gonadotropin (HCG)， progesterone (P)， interleukin-4 (IL-4)， interferon-γ (IFN-γ)， IFN-gamma/IL-4 and adverse reactions were compared between the two groups. Results The success rate of fetal protection in the study group was 88.24%， which was higher than that in the control group (59.80%)， and the difference was statistically significant (P<0.05). The level of IFN-γ and IFN-γ/IL-4 in the study group after intervention were lower than those in the control group， and the difference was statistically significant (P<0.05). The levels of IL-4， HCG， P， and E2 in the study group after intervention were higher than those in the control group， the difference was statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Recurrent abortion with traditional placenta therapy combined with Low Molecular Weight Heparin treatment can significantly improve the success rate of fetal protection， improve the body hormone level and immune function， and the incidence of adverse reactions is low., http://www.100md.com(林志金 杨秀珍 张炯兰)