呼吸道合胞病毒毛细支气管炎与支气管哮喘中炎症因子的研究(1)
[摘要]目的 分析呼吸道合胞病毒(RSV)毛细支气管炎与支气管哮喘(BA)的血清干扰素-γ(IFN-γ)、白介素-4(IL-4)、白介素-10(IL-10)、转化生长因子-β(TGF-β)、白介素-17(IL-17)的水平。方法 选取2017年6月～2018年8月我院收治的200例儿童作为研究对象，按照不同疾病方法分为RSV毛细支气管炎组(50例)、BA组(50例)与非RSV肺炎组(50例)，选择同期健康体检儿童作为对照组(50例)，四组均采用酶联免疫吸附实验(ELISA)，比较四组的血清IFN-γ、IL-4、IL-10、TGF-β、IL-17水平。结果 RSV毛细支气管炎组的IL-17水平高于非RSV肺炎组，差异有统计学意义(P<0.05);BA组IL-17水平高于非RSV肺炎组，差异有统计学意义(P<0.05);RSV毛细支气管组IL-10、TGF-β水平低于非RSV肺炎组，差异有统计学意义(P<0.05);四组的IFN-γ比较，差异无统计学意义(P>0.05)。结论RSV毛细支气管炎与BA均具备相同指标改变，且RSV毛细支气管炎与BA中炎症因子的表达有关。
[关键词]呼吸道合胞病毒毛细支气管炎;支气管哮喘;发病机制;相关性
[中图分类号] R725 [文献标识码] A [文章编号] 1674-4721(2019)6(c)-0078-03
[Abstract] Objective To analyze the serum levels of interferon-γ (IFN-γ)， interleukin-4 (IL-4)， interleukin-10 (IL-10)， transforming growth factor-β (TGF-β)， and interleukin-17(IL-17) in patients with respiratory syncytial virus (RSV) bronchiolitis and bronchial asthma(BA). Methods From June 2017 to August 2018， 200 cases of childrens in our hospital were selected as the research object， according to different diseases， they were divided into RSV bronchiolitis group (50 cases) and BA group (50 cases) and non RSV pneumonia group (50 cases)， choose the health checkup children for the same period as the control group (50 cases)， four groups by enzyme-linked immunosorbent assay (ELISA) method， the levels of IFN-γ， IL-4， IL-10， TGF-β and IL-17 were compared in the four groups. Results The level of IL-17 in the RSV capillary bronchial group was higher than that in the non-RSV pneumonia group， and the difference was statistically significant (P<0.05). Il-17 level in the BA group was higher than that in the non-RSV pneumonia group， and the difference was statistically significant (P<0.05). The levels of IL-10 and TGF-β in the RSV capillary bronchial group were lower than those in the non-RSV pneumonia group (P<0.05). There was no significant difference in IFN-γ between the four groups (P>0.05). Conclusion RSV bronchiolitis and BA have the same index changes， and RSV bronchiolitis is associated with the expression of inflammatory factors in BA.
[Key words] Respiratory syncytial virus capillary bronchitis; Bronchial asthma; Pathogenesis; Correlation
毛細支气管炎在临床又被称为喘憋性肺炎，是一类呼吸道感染性疾病，以婴幼儿为主要发病人群，是由于多种病原体所致病，以呼吸道合胞病毒(RSV)最为常见[1]。根据我国流行病学研究显示，RSV毛细支气管炎是哮喘(BA)发生的高危因素，而在RSV毛细支气管炎发展成BA的高危因素主要与早产、RSV感染、家族过敏史、反复呼吸道感染等密切相关[2]。本研究选取200例研究对象分组，对各项指标进行分析，现报道如下。
1资料与方法
1.1一般资料, http://www.100md.com(杨会兰)
[关键词]呼吸道合胞病毒毛细支气管炎;支气管哮喘;发病机制;相关性
[中图分类号] R725 [文献标识码] A [文章编号] 1674-4721(2019)6(c)-0078-03
[Abstract] Objective To analyze the serum levels of interferon-γ (IFN-γ)， interleukin-4 (IL-4)， interleukin-10 (IL-10)， transforming growth factor-β (TGF-β)， and interleukin-17(IL-17) in patients with respiratory syncytial virus (RSV) bronchiolitis and bronchial asthma(BA). Methods From June 2017 to August 2018， 200 cases of childrens in our hospital were selected as the research object， according to different diseases， they were divided into RSV bronchiolitis group (50 cases) and BA group (50 cases) and non RSV pneumonia group (50 cases)， choose the health checkup children for the same period as the control group (50 cases)， four groups by enzyme-linked immunosorbent assay (ELISA) method， the levels of IFN-γ， IL-4， IL-10， TGF-β and IL-17 were compared in the four groups. Results The level of IL-17 in the RSV capillary bronchial group was higher than that in the non-RSV pneumonia group， and the difference was statistically significant (P<0.05). Il-17 level in the BA group was higher than that in the non-RSV pneumonia group， and the difference was statistically significant (P<0.05). The levels of IL-10 and TGF-β in the RSV capillary bronchial group were lower than those in the non-RSV pneumonia group (P<0.05). There was no significant difference in IFN-γ between the four groups (P>0.05). Conclusion RSV bronchiolitis and BA have the same index changes， and RSV bronchiolitis is associated with the expression of inflammatory factors in BA.
[Key words] Respiratory syncytial virus capillary bronchitis; Bronchial asthma; Pathogenesis; Correlation
毛細支气管炎在临床又被称为喘憋性肺炎，是一类呼吸道感染性疾病，以婴幼儿为主要发病人群，是由于多种病原体所致病，以呼吸道合胞病毒(RSV)最为常见[1]。根据我国流行病学研究显示，RSV毛细支气管炎是哮喘(BA)发生的高危因素，而在RSV毛细支气管炎发展成BA的高危因素主要与早产、RSV感染、家族过敏史、反复呼吸道感染等密切相关[2]。本研究选取200例研究对象分组，对各项指标进行分析，现报道如下。
1资料与方法
1.1一般资料, http://www.100md.com(杨会兰)