氧化苦参碱调节免疫平衡的作用及其对类风湿性关节炎患者炎症水平的影响(1)
[摘要]目的 探討氧化苦参碱调节免疫平衡的作用及其对类风湿性关节炎患者炎症水平的影响。方法 选取2017年1月1日～2018年12月1日我院收治的136例类风湿性关节炎患者作为研究对象，根据随机数字表法分为试验组(68例)与对照组(68例)，其中试验组患者采取氧化苦参碱口服治疗，对照组采取同剂量的安慰剂治疗。比较两组患者治疗前后的免疫功能水平[免疫球蛋白G(IgG)、免疫球蛋白M (IgM)、免疫球蛋白A (IgA)、CD4/CD8]、炎性反应因子水平[白介素-6 (IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)]以及治疗后两组患者的晨僵持续时间、关节压痛评分(VAS评分)、生活能力评分(Barthel评分)。结果 两组患者治疗前的IL-6、TNF-α、CRP水平比较，差异无统计学意义(P>0.05);两组患者治疗后的IL-6、TNF-α、CRP水平均低于治疗前，且试验组低于对照组，差异有统计学意义(P<0.05);两组患者治疗前的IgG、IgM、IgA、CD4/CD8水平比较，差异无统计学意义(P>0.05);两组患者治疗后的IgG、IgM、IgA、CD4/CD8水平均高于治疗前，且试验组高于对照组，差异有统计学意义(P<0.05);试验组患者治疗后的晨僵持续时间短于对照组，关节VAS评分低于对照组，Barthel评分高于对照组，差异均有统计学意义(P<0.05)。结论 在类风湿性关节炎患者的治疗中，采取氧化苦参碱治疗，可明显改善患者的免疫功能，降低患者炎症因子水平，缩短晨僵持续时间，降低关节压痛水平，改善患者的生活能力评分，效果理想。
[关键词]氧化苦参碱;调节免疫平衡;类风湿性关节炎;炎症水平
[中图分类号] R593.22 [文献标识码] A [文章编号] 1674-4721(2019)8(c)-0018-04
[Abstract] Objective To investigate the effects of Oxymatrine on immune balance and inflammation in patients with rheumatoid arthritis. Methods A total of 136 patients with rheumatoid arthritis treated in our hospital from January 1， 2017 to December 1， 2018 were selected as the research objects. They were divided into experimental group (68 cases) and control group (68 cases) by random number table method. The experimental group was treated with Oxymatrine orally， while the control group was treated with the same dose of placebo. The levels of immune function (immunoglobulin G [IgG]， immunoglobulin M [IgM]， immunoglobulin A [IgA]， CD4/CD8)， inflammatory reaction factors (interleukin 6 [IL-6]， tumor necrosis factor-α [TNF-α]， C-reactive protein [CRP]) before and after treatment were compared between the two groups. The duration of morning stiffness and joint tenderness scores (VAS scores)， Barthel scores of the two groups were observed after treatment. Results There were no significant differences in the levels of IL-6， TNF-α and CRP between the two groups before treatment (P>0.05). The levels of IL-6， TNF-α and CRP in the two groups after treatment were lower than those before treatment， and the levels of IL-6， TNF-α and CRP in the experimental group were lower than those in the control group (P<0.05). There were no significant differences in the levels of IgG， IgM， IgA and CD4/CD8 between the two groups before treatment (P>0.05). The levels of IgG， IgM， IgA， CD4/CD8 in the two groups after treatment were higher than those before treatment ， and the levels of IgG， IgM， IgA， CD4/CD8 in experimental group were higher than those in the control group (P<0.05). The duration of morning stiffness in the experimental group was shorter than that in the control group， the VAS score of the joint was lower than that in the control group， and the Barthel score was higher than that of the control group， the differences were statistically significant (P<0.05). Conclusion In the treatment of rheumatoid arthritis patients， Oxymatrine treatment can significantly improve the immune function of patients to achieve balance， reduce the level of inflammatory factors， shorten the duration of morning stiffness， reduce the level of joint tenderness， and improve the life ability score of patients， the effect is ideal., http://www.100md.com(黎威 张邵宁)
[关键词]氧化苦参碱;调节免疫平衡;类风湿性关节炎;炎症水平
[中图分类号] R593.22 [文献标识码] A [文章编号] 1674-4721(2019)8(c)-0018-04
[Abstract] Objective To investigate the effects of Oxymatrine on immune balance and inflammation in patients with rheumatoid arthritis. Methods A total of 136 patients with rheumatoid arthritis treated in our hospital from January 1， 2017 to December 1， 2018 were selected as the research objects. They were divided into experimental group (68 cases) and control group (68 cases) by random number table method. The experimental group was treated with Oxymatrine orally， while the control group was treated with the same dose of placebo. The levels of immune function (immunoglobulin G [IgG]， immunoglobulin M [IgM]， immunoglobulin A [IgA]， CD4/CD8)， inflammatory reaction factors (interleukin 6 [IL-6]， tumor necrosis factor-α [TNF-α]， C-reactive protein [CRP]) before and after treatment were compared between the two groups. The duration of morning stiffness and joint tenderness scores (VAS scores)， Barthel scores of the two groups were observed after treatment. Results There were no significant differences in the levels of IL-6， TNF-α and CRP between the two groups before treatment (P>0.05). The levels of IL-6， TNF-α and CRP in the two groups after treatment were lower than those before treatment， and the levels of IL-6， TNF-α and CRP in the experimental group were lower than those in the control group (P<0.05). There were no significant differences in the levels of IgG， IgM， IgA and CD4/CD8 between the two groups before treatment (P>0.05). The levels of IgG， IgM， IgA， CD4/CD8 in the two groups after treatment were higher than those before treatment ， and the levels of IgG， IgM， IgA， CD4/CD8 in experimental group were higher than those in the control group (P<0.05). The duration of morning stiffness in the experimental group was shorter than that in the control group， the VAS score of the joint was lower than that in the control group， and the Barthel score was higher than that of the control group， the differences were statistically significant (P<0.05). Conclusion In the treatment of rheumatoid arthritis patients， Oxymatrine treatment can significantly improve the immune function of patients to achieve balance， reduce the level of inflammatory factors， shorten the duration of morning stiffness， reduce the level of joint tenderness， and improve the life ability score of patients， the effect is ideal., http://www.100md.com(黎威 张邵宁)