同型半胱氨酸、叶酸与维生素B12水平的相关性分析及不良妊娠结局的危险因素考察(1)
[摘要]目的 探讨同型半胱氨酸、叶酸与维生素B12水平的相关性及不良妊娠结局的危险因素。方法 选择2017年6月～2018年6月我院收治的不良妊娠结局孕妇50例作为研究组;另选择同时间段我院收治的无不良妊娠结局孕妇50例作为对照组。观察比较两组的血清检测结果，分析同型半胱氨酸与叶酸、维生素B12水平的相关性，并采用非条件Logistic多元逐步回归分析不良妊娠相关危险因素。结果 研究组的同型半胱氨酸为(11.20±2.85)μmol/L，高于对照组的(9.35±1.02)μmol/L，差异有统计学意义(P<0.05);研究组叶酸为(6.10±1.55)ng/ml，低于对照组的(6.95±1.68)ng/ml，差异有统计学意义(P<0.05);研究组维生素B12为(78.30±28.75)pg/ml，低于对照组的(98.35±45.50)pg/ml，差异有统计学意义(P<0.05);经Pearson相关性分析结果可知，血清同型半胱氨酸水平与叶酸表现为负相关关系(r=-0.088，P=0.000);血清同型半胱氨酸水平与维生素B12水平表现为负相关关系(r=-0.109，P=0.001);非条件Logistic多元逐步回归分析结果提示，同型半胱氨酸升高、维生素B12降低、叶酸降低均属于不良妊娠的危险因素(β=0.541，OR=1.708，95%CI=0.039～1.895，P<0.05;β=0.003，OR=1.001，95%CI=0.001～1.109，P<0.05;β=0.004，OR=1.002，95%CI=0.001～1.010，P<0.05)。结论 不良妊娠结局的相关危险因素包括同型半胱氨酸升高、維生素B12水平降低、叶酸降低等，因此，临床结合孕妇自身情况，应加强同型半胱氨酸监测，加强维生素B12、叶酸水平监测，以有效预防发生不良妊娠结局。
[关键词]同型半胱氨酸;叶酸;维生素B12水平;不良妊娠结局;相关性
[中图分类号] R581.2 [文献标识码] A [文章编号] 1674-4721(2020)1(c)-0165-03
[Abstract] Objective To investigate the correlation between homocysteine， folic acid and vitamin B12 levels and the risk factors of adverse pregnancy outcome. Methods A total of 50 pregnant women with adverse pregnancy outcome from June 2017 to June 2018 were selected as the study group， and 50 pregnant women with no adverse pregnancy outcome in the same time period were selected as the control group. The results of serum test were observed and compared， and the correlation between homocysteine and folic acid and vitamin B12 levels was analyzed， and the risk factors related to adverse pregnancy were analyzed by unconditional Logistic multiple stepwise regression analysis. Results The homocysteine in the study group was (11.20±2.85) μmol/L， which was higher than that in the control group (9.35±1.02) μmol/L， and the difference was statistically significant (P<0.05). The folic acid index in the study group was (6.10±1.55) ng/ml， lower than that in the control group (6.95±1.68) ng/ml， and the difference was statistically significant (P<0.05). The vitamin B12 index in the study group was (78.30±28.75) pg/ml， which was lower than that in the control group (98.35 ±45.50) pg/ml， and the difference was statistically significant (P<0.05). The results of Pearson correlation analysis showed that there was a negative correlation between serum homocysteine level and folic acid (r=-0.088， P=0.000). The serum homocysteine level was negatively correlated with the level of vitamin B12 (r=-0.109， P=0.001). Non-conditional Logistic multivariate regression analysis showed that the increase of homocysteine， the decrease of vitamin B12 and the decrease of folic acid were all risk factors of adverse pregnancy (β=0.541， OR=1.708， 95%CI=0.039-1.895， P<0.05; β=0.003， OR=1.001， 95%CI=0.001-1.109， P<0.05; β=0.004， OR=1.002， 95%CI=0.001-1.010， P<0.05). Conclusion The related risk factors of adverse pregnancy outcome include the increase of homocysteine， the decrease of vitamin B12 level and the decrease of folic acid. Therefore， combined with the situation of pregnant women， the monitoring of homocysteinemia， vitamin B12 and folic acid levels should be strengthen in order to effectively prevent the adverse pregnancy outcome., http://www.100md.com(李朝辉 胡雅 区敏怡)
[关键词]同型半胱氨酸;叶酸;维生素B12水平;不良妊娠结局;相关性
[中图分类号] R581.2 [文献标识码] A [文章编号] 1674-4721(2020)1(c)-0165-03
[Abstract] Objective To investigate the correlation between homocysteine， folic acid and vitamin B12 levels and the risk factors of adverse pregnancy outcome. Methods A total of 50 pregnant women with adverse pregnancy outcome from June 2017 to June 2018 were selected as the study group， and 50 pregnant women with no adverse pregnancy outcome in the same time period were selected as the control group. The results of serum test were observed and compared， and the correlation between homocysteine and folic acid and vitamin B12 levels was analyzed， and the risk factors related to adverse pregnancy were analyzed by unconditional Logistic multiple stepwise regression analysis. Results The homocysteine in the study group was (11.20±2.85) μmol/L， which was higher than that in the control group (9.35±1.02) μmol/L， and the difference was statistically significant (P<0.05). The folic acid index in the study group was (6.10±1.55) ng/ml， lower than that in the control group (6.95±1.68) ng/ml， and the difference was statistically significant (P<0.05). The vitamin B12 index in the study group was (78.30±28.75) pg/ml， which was lower than that in the control group (98.35 ±45.50) pg/ml， and the difference was statistically significant (P<0.05). The results of Pearson correlation analysis showed that there was a negative correlation between serum homocysteine level and folic acid (r=-0.088， P=0.000). The serum homocysteine level was negatively correlated with the level of vitamin B12 (r=-0.109， P=0.001). Non-conditional Logistic multivariate regression analysis showed that the increase of homocysteine， the decrease of vitamin B12 and the decrease of folic acid were all risk factors of adverse pregnancy (β=0.541， OR=1.708， 95%CI=0.039-1.895， P<0.05; β=0.003， OR=1.001， 95%CI=0.001-1.109， P<0.05; β=0.004， OR=1.002， 95%CI=0.001-1.010， P<0.05). Conclusion The related risk factors of adverse pregnancy outcome include the increase of homocysteine， the decrease of vitamin B12 level and the decrease of folic acid. Therefore， combined with the situation of pregnant women， the monitoring of homocysteinemia， vitamin B12 and folic acid levels should be strengthen in order to effectively prevent the adverse pregnancy outcome., http://www.100md.com(李朝辉 胡雅 区敏怡)
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