5-氨基酮戊酸光动力与重组人干扰素α-2b凝胶治疗宫颈高危型人乳头瘤病毒持续感染的效果比较(1)
[摘要]目的 探究5-氨基酮戊酸光动力疗法、重组人干扰素α-2b凝胶治疗宫颈高危型人乳头瘤病毒(HPV)持续感染的临床效果及安全性，为临床医师选择合理的治疗方案提供参考。方法 选取2017年9月～2018年11月沈阳美德因妇儿医院诊治的86例宫颈高危型HPV持续感染阳性患者作为研究对象，依据随机数字表法将其分成观察组和对照组，每组各43例。观察组患者采用5-氨基酮戊酸光动力疗法，对照组患者应用重组人干扰素α-2b凝胶治疗。比较两组患者的临床治疗总有效率、HPV转阴时间、症状消失时间、治疗前后炎症因子[白介素-6(IL-6)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)]水平及不良反应发生情况。结果 观察组患者的临床治疗总有效率为93.02%，高于对照组的74.42%，差异有统计学意义(P<0.05)。观察组患者的HPV转阴时间、症状消失时间均短于对照组，差异有统计学意义(P<0.05)。观察组患者治疗后的炎症因子水平均低于对照组，差异有统计学意义(P<0.05)。两组均未发生严重的不良反应。结论 在宫颈高危型HPV持續感染患者治疗中，5-氨基酮戊酸光动力疗法、重组人干扰素α-2b凝胶均能取得效果，且安全性较高，但5-氨基酮戊酸光动力疗法效果更佳，可促进患者身体恢复，值得借鉴。
[关键词]5-氨基酮戊酸光动力疗法;重组人干扰素α-2b凝胶;宫颈高危型人乳头瘤病毒持续感染;临床疗效;安全性
[中图分类号] R737.33 [文献标识码] A [文章编号] 1674-4721(2020)3(a)-0128-04
Effect comparison of 5-aminoketovaleric acid photodynamic and Recombinant Human Interferon α-2b Gel in the treatment of cervical high-risk human papilloma virus persistent infection
LI Lu
Gynecological Center， Shenyang Madein Women′s and Children′s Hospital， Liaoning Province， Shenyang 110031， China
[Abstract] Objective To explore the clinical effect and safety of 5-aminolevulinic acid photodynamic therapy and Recombinant Human Interferon α-2b Gel in the treatment of cervical high-risk human papilloma virus (HPV) persistent infection， so as to provide reference for clinicians to select a reasonable treatment plan. Methods A total of 86 patients with cervical high-risk HPV persistent infection diagnosed and treated in Shenyang Madein Women′s and Children′s Hospital from September 2017 to November 2018 were selected as the research objects. They were divided into observation group and control group according to the random number table method， 43 cases in each group. The observation group was treated with 5-aminolevulinic acid photodynamic therapy， while the control group was treated with Recombinant Human Interferon α-2b Gel. The total effective rate of clinical treatment， HPV negative time， symptom disappearance time， inflammatory factor (interleukin-6 [IL-6]， interleukin-8 [IL-8]， tumor necrosis factor-α [TNF-α]) levels and incidence of adverse reactions were compared between the two groups. Results The total effective rate of clinical treatment in the observation group was 93.02%， which was higher than 74.42% in the control group， and the difference was statistically significant (P<0.05). The negative time of HPV and the disappearance time of symptoms in the observation group were shorter than those in the control group， and the differences were statistically significant (P<0.05). The levels of inflammatory factors in the observation group after treatment were lower than those in the control group， and the differences were statistically significant (P<0.05). There were no serious adverse reactions in both groups. Conclusion In the treatment of cervical high-risk HPV persistent infection， both 5-aminolevulinic acid photodynamic therapy and Recombinant Human Interferon α-2b Gel can achieve clinical results and higher safety， but 5-aminolevulinic acid photodynamic therapy has better clinical effect and can promote recovery of patients， which is worth learning., 百拇医药(李璐)
[关键词]5-氨基酮戊酸光动力疗法;重组人干扰素α-2b凝胶;宫颈高危型人乳头瘤病毒持续感染;临床疗效;安全性
[中图分类号] R737.33 [文献标识码] A [文章编号] 1674-4721(2020)3(a)-0128-04
Effect comparison of 5-aminoketovaleric acid photodynamic and Recombinant Human Interferon α-2b Gel in the treatment of cervical high-risk human papilloma virus persistent infection
LI Lu
Gynecological Center， Shenyang Madein Women′s and Children′s Hospital， Liaoning Province， Shenyang 110031， China
[Abstract] Objective To explore the clinical effect and safety of 5-aminolevulinic acid photodynamic therapy and Recombinant Human Interferon α-2b Gel in the treatment of cervical high-risk human papilloma virus (HPV) persistent infection， so as to provide reference for clinicians to select a reasonable treatment plan. Methods A total of 86 patients with cervical high-risk HPV persistent infection diagnosed and treated in Shenyang Madein Women′s and Children′s Hospital from September 2017 to November 2018 were selected as the research objects. They were divided into observation group and control group according to the random number table method， 43 cases in each group. The observation group was treated with 5-aminolevulinic acid photodynamic therapy， while the control group was treated with Recombinant Human Interferon α-2b Gel. The total effective rate of clinical treatment， HPV negative time， symptom disappearance time， inflammatory factor (interleukin-6 [IL-6]， interleukin-8 [IL-8]， tumor necrosis factor-α [TNF-α]) levels and incidence of adverse reactions were compared between the two groups. Results The total effective rate of clinical treatment in the observation group was 93.02%， which was higher than 74.42% in the control group， and the difference was statistically significant (P<0.05). The negative time of HPV and the disappearance time of symptoms in the observation group were shorter than those in the control group， and the differences were statistically significant (P<0.05). The levels of inflammatory factors in the observation group after treatment were lower than those in the control group， and the differences were statistically significant (P<0.05). There were no serious adverse reactions in both groups. Conclusion In the treatment of cervical high-risk HPV persistent infection， both 5-aminolevulinic acid photodynamic therapy and Recombinant Human Interferon α-2b Gel can achieve clinical results and higher safety， but 5-aminolevulinic acid photodynamic therapy has better clinical effect and can promote recovery of patients， which is worth learning., 百拇医药(李璐)