丙种球蛋白辅助治疗儿童重症腺病毒肺炎的临床效果(1)
[摘要]目的 探讨丙种球蛋白辅助治疗儿童重癥腺病毒肺炎(SAP)的临床效果。方法 回顾性分析2013年5月～2018年5月我院收治的150例住院SAP患儿的临床资料，根据治疗过程中是否使用丙种球蛋白分为丙种球蛋白组(75例)和对照组(75例)。丙种球蛋白组使用丙种球蛋白辅助治疗，对照组使用常规治疗。比较两组的治疗效果、发热时间、住院时间、机械通气时间、不良反应总发生率及死亡率。结果 丙种球蛋白组的治疗总有效率高于对照组，差异有统计学意义(P<0.05);丙种球蛋白组的发热时间、住院时间及机械通气时间短于对照组，差异均有统计学意义(P<0.05);两组的不良反应总发生率和死亡率比较，差异无统计学意义(P>0.05)。结论 丙种球蛋白辅助治疗儿童SAP能提高患者的治疗效果，缩短患者的发热时间、住院时间及机械通气时间，不增加患者的不良反应和死亡率，值得临床推广应用。
[关键词]肺炎;腺病毒;儿童;丙种球蛋白
[中图分类号] R72 [文献标识码] A [文章编号] 1674-4721(2020)3(a)-0145-03
Clinical effect of Gamma Globulin as adjuvant treatment for severe adenoviral pneumonia in children
ZHOU Ming-jian CHEN Xiang-jian ZHUO Xiao-feng LIU Xue-feng▲
Department of Paediatrics， Ningde Hospital Affiliated to Fujian Medical University， Fujian Province， Ningde 352100， China
[Abstract] Objective To investigate the clinical effect of Gamma Globulin as adjuvant treatment for severe adenoviral pneumonia (SAP) in children. Methods The clinical data of 150 inpatients with SAP admitted in our hospital from May 2013 to May 2018 were retrospectively analyzed， they were divided into the Gamma Globulin group (75 patients) and the control group (75 patients) based on whether or not gamma globulin was used during treatment. The Gamma Globulin group was treated with adjuvant Gamma Globulin， the control group was treated with conventional therapy. The treatment effect， fever time， hospital stay， mechanical ventilation time， total incidence of adverse reactions and mortality were compared between the two groups. Results The total effective rate of the Gamma Globulin group was higher than that of the control group， the difference was statistically significant (P<0.05). The fever time， hospitalization time， and mechanical ventilation time of the Gamma Globulin group were shorter than those of the control group， the differences were statistically significant (P<0.05). There were no significant differences in the total incidence and mortality of adverse reactions between the two groups (P>0.05). Conclusion Gamma Globulin adjuvant treatment of children SAP can improve the treatment effect of patients， shorten the fever time， hospitalization time and mechanical ventilation time of patients， without increasing the adverse reactions and mortality of the patients， which is worthy of clinical promotion and application.
[Key words] Pneumonia; Adenovirus; Children; Gamma Globulin, http://www.100md.com(周明建 陈向坚 卓晓峰 刘学锋)
[关键词]肺炎;腺病毒;儿童;丙种球蛋白
[中图分类号] R72 [文献标识码] A [文章编号] 1674-4721(2020)3(a)-0145-03
Clinical effect of Gamma Globulin as adjuvant treatment for severe adenoviral pneumonia in children
ZHOU Ming-jian CHEN Xiang-jian ZHUO Xiao-feng LIU Xue-feng▲
Department of Paediatrics， Ningde Hospital Affiliated to Fujian Medical University， Fujian Province， Ningde 352100， China
[Abstract] Objective To investigate the clinical effect of Gamma Globulin as adjuvant treatment for severe adenoviral pneumonia (SAP) in children. Methods The clinical data of 150 inpatients with SAP admitted in our hospital from May 2013 to May 2018 were retrospectively analyzed， they were divided into the Gamma Globulin group (75 patients) and the control group (75 patients) based on whether or not gamma globulin was used during treatment. The Gamma Globulin group was treated with adjuvant Gamma Globulin， the control group was treated with conventional therapy. The treatment effect， fever time， hospital stay， mechanical ventilation time， total incidence of adverse reactions and mortality were compared between the two groups. Results The total effective rate of the Gamma Globulin group was higher than that of the control group， the difference was statistically significant (P<0.05). The fever time， hospitalization time， and mechanical ventilation time of the Gamma Globulin group were shorter than those of the control group， the differences were statistically significant (P<0.05). There were no significant differences in the total incidence and mortality of adverse reactions between the two groups (P>0.05). Conclusion Gamma Globulin adjuvant treatment of children SAP can improve the treatment effect of patients， shorten the fever time， hospitalization time and mechanical ventilation time of patients， without increasing the adverse reactions and mortality of the patients， which is worthy of clinical promotion and application.
[Key words] Pneumonia; Adenovirus; Children; Gamma Globulin, http://www.100md.com(周明建 陈向坚 卓晓峰 刘学锋)
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