[摘要]目的 探讨恒温腹腔热灌注化疗(HIPEC)联合全身静脉化疗治疗恶性腹水的效果及安全性。方法 选取2015年6月～2018年5月我院收治的80例恶性腹水患者，利用随机数字表法分为观察组与对照组，每组40例，对照组给予全身静脉化疗治疗，观察组在对照组基础上给予恒温HIPEC治疗，比较两组治疗效果。结果 观察组总有效率为95.00%，高于对照组的80.00%，差异有统计学意义(P<0.05);观察组治疗后生活质量量表中生理功能、生理职能、躯体疼痛、总体健康、活力、社会功能、情感职能、精神健康评分均高于对照组，差异有统计学意义(P<0.05);两组毒副反应发生率比较，差异无統计学意义(P>0.05)。结论 恒温HIPEC联合全身静脉化疗治疗恶性腹水安全有效。

    [关键词]恶性腹水;腹腔热灌注化疗;静脉化疗;毒副反应;生活质量

    [中图分类号] R735 [文献标识码] A [文章编号] 1674-4721(2020)6(b)-0099-04

    [Abstract] Objective To explore effect and safety of homothermal hyperthermic-itraperitoneal chemotherapy (HIPEC) combined with systemic intravenous chemotherapy (SIC) in treatment of malignant ascites. Methods Eighty malignant ascites patients admitted to our hospital from June 2015 to May 2018 were enrolled. They were divided into observation group and control group by random number table method ......