小剂量阿司匹林对宫腔粘连分离术后子宫动脉血流及子宫内膜影响的Meta分析(1)
[摘要]目的 評价宫腔镜宫腔粘连分离术后应用小剂量阿司匹林对子宫动脉血流及子宫内膜的影响。方法 检索PubMed、Web of Science、MEDLINE、CNKI、万方等数据库，检索时限均为各数据库建库至2019年12月，制订严格的纳入和剔除标准，对纳入文献进行质量评价，采用Review Manager 5.3软件进行Meta分析。结果 最终纳入7篇随机对照试验(RCT)文献。Meta分析结果示，试验组的子宫动脉阻力指数(RI)低于对照组，差异有统计学意义[WMD=-0.17，95%CI(-0.19，-0.14)，P<0.000 01]。试验组的搏动指数(PI)低于对照组，差异有统计学意义[WMD=-0.33，95%CI(-0.49，-0.17)，P<0.0001]。试验组的子宫内膜血管化指数(VI)高于对照组，差异有统计学意义[WMD=1.01，95%CI(0.46，1.55)，P=0.0003]。试验组的血流指数(FI)、血管化血流指数(VFI)均分别高于对照组，差异有统计学意义[WMD=4.53，95%CI(3.45，5.61)，P<0.000 01;WMD=0.30，95%CI(0.24，0.35)，P<0.000 01)]。试验组的A型子宫内膜比例高于对照组，差异有统计学意义[OR=3.01，95%CI(1.38，6.60)，P=0.006]。结论 宫腔粘连分离术后小剂量阿司匹林的应用可以改善子宫动脉血流，增加子宫内膜血流灌注，A型子宫内膜比例增加，促进子宫内膜的修复。
[关键词]宫腔镜;宫腔粘连;小剂量阿司匹林;Meta分析
[中图分类号] R711.32 [文献标识码] A [文章编号] 1674-4721(2020)9(c)-0012-04
[Abstract] Objective To evaluate the effect of low-dose Aspirin on uterine arterial blood flow and endometrium after transcervical resection of adhesion. Methods PubMed， Web of Science， MEDLINE， CNKI， Wanfang and other databases were searched， the retrieval time was from the database construction to December 2019， strict inclusion and exclusion criteria were formulated， quality evaluation of included literature was conducted， and Review Manager 5.3 software was used for Meta-analysis. Results Finally， 7 random control trial (RCT) articles were included. The results of Meta-analysis showed that the uterine artery resistance index (RI) in the experimental group was lower than that in the control group， and the difference was statistically significant (WMD=-0.17， 95%CI[-0.19， -0.14]， P<0.000 01). The pulsatility index (PI) in the experimental group was lower than that in the control group， and the difference was statistically significant (WMD=-0.33， 95%CI[-0.49， -0.17]， P<0.0001). The endometrial vascularization index (VI) in the experimental group was higher than that in the control group， and the difference was statistically significant (WMD=1.01， 95%CI[0.46， 1.55]， P=0.0003). The blood flow index (FI) and vascularized blood flow index (VFI) in the experimental group were higher than those in the control group， and the differences were statistically significant (WMD=4.53， 95%CI[3.45， 5.61]， P<0.000 01; WMD=0.30， 95%CI[0.24， 0.35]， P<0.000 01). The proportion of type A endometrium in the experimental group was higher than that in the control group， and the difference was statistically significant (OR=3.01， 95%CI[1.38， 6.60]， P=0.006). Conclusion The application of low-dose Aspirin after transcervical resection of adhesion can improve the uterine artery blood flow， increase endometrium perfusion and the proportion of type A endometrium， promote the repair of endometrium., http://www.100md.com(张欢 杨贵霞 马明明)
[关键词]宫腔镜;宫腔粘连;小剂量阿司匹林;Meta分析
[中图分类号] R711.32 [文献标识码] A [文章编号] 1674-4721(2020)9(c)-0012-04
[Abstract] Objective To evaluate the effect of low-dose Aspirin on uterine arterial blood flow and endometrium after transcervical resection of adhesion. Methods PubMed， Web of Science， MEDLINE， CNKI， Wanfang and other databases were searched， the retrieval time was from the database construction to December 2019， strict inclusion and exclusion criteria were formulated， quality evaluation of included literature was conducted， and Review Manager 5.3 software was used for Meta-analysis. Results Finally， 7 random control trial (RCT) articles were included. The results of Meta-analysis showed that the uterine artery resistance index (RI) in the experimental group was lower than that in the control group， and the difference was statistically significant (WMD=-0.17， 95%CI[-0.19， -0.14]， P<0.000 01). The pulsatility index (PI) in the experimental group was lower than that in the control group， and the difference was statistically significant (WMD=-0.33， 95%CI[-0.49， -0.17]， P<0.0001). The endometrial vascularization index (VI) in the experimental group was higher than that in the control group， and the difference was statistically significant (WMD=1.01， 95%CI[0.46， 1.55]， P=0.0003). The blood flow index (FI) and vascularized blood flow index (VFI) in the experimental group were higher than those in the control group， and the differences were statistically significant (WMD=4.53， 95%CI[3.45， 5.61]， P<0.000 01; WMD=0.30， 95%CI[0.24， 0.35]， P<0.000 01). The proportion of type A endometrium in the experimental group was higher than that in the control group， and the difference was statistically significant (OR=3.01， 95%CI[1.38， 6.60]， P=0.006). Conclusion The application of low-dose Aspirin after transcervical resection of adhesion can improve the uterine artery blood flow， increase endometrium perfusion and the proportion of type A endometrium， promote the repair of endometrium., http://www.100md.com(张欢 杨贵霞 马明明)