瑞格列奈或格列吡嗪联合甘精胰岛素治疗初诊2型糖尿病的观察
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【摘要】 目的 比较瑞格列奈或格列吡嗪联合甘精胰岛素治疗对初诊2型糖尿病患者降糖的疗效及对β细胞功能的影响。方法 将笔者所在医院门诊初诊的2型糖尿病患者45例，随机分成瑞格列奈组(瑞格列奈+甘精胰岛素，n=23)和格列吡嗪组(格列吡嗪+甘精胰岛素，n=22)。结果 两组治疗3个月后餐前和餐后的末梢血糖及HbA1c均较治疗前明显下降(P<0.01)。结论 瑞格列奈(1 mg,3次/d)联合甘精胰岛素控制餐后血糖、HbA1c和改善胰岛β细胞分泌功能较格列吡嗪(5 mg,1次/d)联合组更好。
【关键词】 糖尿病； 瑞格列奈； 格列吡嗪； 甘精胰岛素
Clinical observation of repaglinide or glipizide combined with glargine in the treatment of newly diagnosed type 2 diabetic patients SHI Chun-hui,LI Wen-qin.Danyang City People’s Hospital，Danyang 212300,China
【Abstract】 Objective The effects of repaglinide or glipizide combined with glargine on glucose metabolism and β-cell function were observed in the patients with newly diagnosed type 2 diabetes.Methods The 45 patients with newly diagnosed type 2 were randomly divided in to Repaglinide group (Repaglinide+Glargine；n=23) and Glipizide group (Glipizide+Glargine;n=22).Results The preprandial capillary blood glucose, postprandial capillary blood glucose and HbA1c in both groups after 3-month treatment were significantly reduced as compared with those at baseline(P<0.01).Conclusion The treatment with repaglinide(1 mg,tid)plus glargine was more efficient than glipizide (5 mg, qd) plus glargine in improving β-cell function, ameliorating HbA1c and postprandial blood glucose excursions in patients with type 2 diabetes ......
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