保肾宁胶囊对甘油造成的急性肾功能衰竭少尿模型的影响(1)
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【摘要】 目的 采用甘油造成急性肾功能衰竭少尿模型,观察保肾宁胶囊对急性肾功能衰竭的影响。方法 SD大鼠随机分为对照组、尿毒清阳性对照组、模型组和不同剂量保肾宁胶囊干预组,观察保肾宁胶囊对ARF大鼠一般情况、肾功能及电解质的影响。结果 保肾宁胶囊11.0 g生药/kg能增高甘油所致急性肾衰大鼠的尿量,改善少尿症状,能显著降低血Cr水平,使肾功能得到一定程度的改善;5.5、2.8g生药/kg剂量可纠正急性肾衰大鼠的电解质紊乱,使血钠异常得到明显改善。结论 保肾宁胶囊对甘油引起的急性肾功能衰竭具有一定的改善作用。
【关键词】 急性肾功能衰竭; 保肾宁胶囊; 肾功能
The effect of Baoshenning capsules on acute renal failure rat model induced by glycerine JIA Ning, ZHENG Jing,WANG Han.The Fifth Affiliated Hospital of Zhongshan University,Zhuhai 519000,China
【Abstract】 Objective To explore the effect of baoshenning capsules on acute renal failure (ARF)rat model by intramuscular injection of glycerine.Methods SD rats were invided into seven groups randomly:normal groups,positive control groups treated by niaoduqing,model groups and treated groups with baoshenning capsule,observe the effect of baoshenning capsule on acute renal rat's general condition,renal function and electrolyte ......
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