基金项目：广东省大学生创新实验项目(NO.1055810111)

    作者单位：510080 中山大学中山医学院

    通讯作者：李博斐

    【摘要】 microRNA(miRNA)是一组长度约20～23个核苷酸的单链非编码RNA，在转录后水平调控靶基因的表达。近年来的研究表明，部分miRNA的异常表达与人类某些类型肿瘤的发生、发展密切相关。本文主要对鼻咽癌以及其相关的miRNA的最新研究进展展开综述。

    【关键词】 miRNA； 鼻咽癌； 综述

    MicroRNA and Nasopharyngeal carcinoma SHEN Lu-jun,LI Bo-fei,HONG Shao-dong,LI Chang-chuan.Medical School of Sun Yat-sen University,Guangzhou 510080,China

    【Abstract】 MicroRNAs (miRNAs) represent a conserved class of small noncoding RNAs that are 20 to 23 nucleotides in length,which can regulate gene expression in cells.Recent research show miRNAs play important roles in physical development, death, proliferation and differentiation of cells.hormone secretion and carcinogenesis. This article reviews the advances in the research of the functions of miRNAs in nasopharyngeal carcinoma in recent years and the mechanism of miRNA action to provide important insight into the roles of microRNAs in NPC.

    【Key words】 miRNA; NPC; Review

    microRNA(miRNAs)是一类长约20～23个核苷酸左右的单链小分子RNA ......