酒精对雄性大鼠性激素\精浆果糖\精浆锌的影响(1)
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【摘要】目的：研究酒精对雄性大鼠性激素(睾酮、卵泡刺激素、黄体生成素)、精浆生化(果糖、锌)的影响。方法：40只健康雄性成年SD大鼠随机分为四组，各组每日分别给予酒精0 g/kg、2.7 g/kg、4.5 g/kg、7.5 g/kg灌胃，连续13周。测定各组大鼠精浆果糖、精浆锌，血清T、LH、FSH含量。结果：各酒精组T、FSH、LH水平均低于正常对照组，差异均有统计学意义(P<0.05或P<0.01)；各酒精组精浆果糖、精浆锌水平均低于正常对照组，差异均有统计学意义(P<0.05或P<0.01)。结论：酒精可导致雄性大鼠生殖内分泌系统损害，抑制雄性大鼠附属性腺的分泌。
【关键词】酒精；男性不育；性激素；精浆生化；雄性大鼠
Effect of Alcohol Consumption on Sex Hormones，Pure Berries Sugar and seminal Plasma Zinc of Male Rats/YANG Xiang-feng，XU Ji-xiu，LIANG Ting-yu//Medical Innovation of China，2012，9(10)：009-011
【Abstract】Objective：To investigate the effect ofalcohol consumption on the sex hormones testosterone(T)，follicle-stimulating hormone(FSH)，luteinizing hormone(LH)and seminal plasma biochemical(fructose，zinc)of male rats.Methods：40 healthySprague-Dawley adult male rats were randomly divided into four groups.Different doses of alcohol(0 g/kg，2 g/kg.7 g/kg，4 g/kg.5 g/kg，7.5 g/kg) were administrated to the rats for 13 weeks by agastric tube.Seminal plasma biochemical(fructose、zinc)and the serum sexual hormones(T，LH，FSH)were determined.Results：Compared with control group，Serum T and LH、FSH levels of each alcohol in treated group are below normal control group，and there were significant differences between them(P<0.05 or P<0.01)；Pure berries sugar content and seminal plasma zinc content of each alcohol in treated group are below normal control group，and there were significant differences between them(P<0.05 or P<0.01).Conclusion：Alcohol can lead to damage of reproductive endocrine system in male rats.Alcohol can restrain accessory glands secrete of the male rats.
【Key words】Alcohol;Male infertility;Sex hormones;Seminal plasma biochemical;Male rats
First-author’s address：The First Hospital of Shanxi Medical University，Taiyuan 030000，China
doi：10.3969/j.issn.1674-4985.2012.10.004
在中华民族的历史长河中，酒及酒文化一直占据着重要地位，素有无酒不成席之说。过度饮酒对身体的危害很大，特别是对男性不育方面。从遗传学角度分析，酒精对人体生殖细胞的损伤，是导致出生缺陷的重要原因之一[1-2]。有关男性生殖的状况和研究是近十多年来男性学研究的热门话题。研究表明，人类的生殖功能正逐渐退化，在过去五十年内，人类精液质量下降了近一半，将来不育症的发生率可能高于目前文献报道的12%~15%，甚至达到30%以上[3] ......
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