盐酸川芎嗪注射液治疗煤工尘肺合并肺动脉高压的临床研究(1)
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【摘要】目的：评价盐酸川芎嗪注射液治疗煤工尘肺合并肺动脉高压的疗效。方法：将124例煤工尘肺合并肺动脉高压患者随机分为川芎嗪治疗组(60例)和常规治疗组(64例)。常规治疗组给予抗生素、吸氧、平喘、祛痰、调节水电解质等常规治疗；川芎嗪治疗组在常规治疗基础上配以盐酸川芎嗪注射液治疗。共治疗40 d，治疗前后进行6 min步行试验及检测肺动脉压力。结果：与同组治疗前及常规治疗组治疗40 d后比较，川芎嗪治疗组治疗40 d后6 min步行距离均明显延长(P<0.05)，肺动脉压力均明显降低(P<0.05)。常规治疗组治疗前、后上述指标比较差异无统计学意义(P>0.05)。结论：盐酸川芎嗪注射液是治疗煤工尘肺合并肺动脉高压的有效药物。
【关键词】盐酸川芎嗪注射液；煤工尘肺；肺动脉高压
The Clinical Study on Ligustrazine Hydrochloride Injection in Treatment of Coal Worker’s Pneumoconiosis Combined with Pulmonary Arterial Hypertension/LIU Ye-liang.//Medical Innovation of China，2012，9(11)：003-004
【Abstract】Objective：To evaluate the effects of Ligustrazine Hydrochloride Injection in treatment of pneumoconiosis combined with pulmonary arterial hypertension in coal workers.Methods：124 coal workers with pneumoconiosis combined with pulmonary artery hypertension were randomly divided into Ligustrazine Hydrochloride Injection treatment group(n=60) and routine treatment group(n=64).The routine treatment group was given antibiotics，oxygen inhalation，asthma，expectorant，regulation of water-electrolyte and other routine treatment.The Ligustrazine Hydrochloride Injection treatment group was given routine treatment and Ligustrazine Hydrochloride Injection.Before and after treatment，change of 6 min walk test and pulmonary arterial pressure after 40 days were measured.Results：In the Ligustrazine Hydrochloride Injection treatment group，the 6min walk test increased after 40 days compared with routine treatment group and before treatment in the same group (P<0.05)，while the pulmonary arterial pressure decreased after 40 days (P<0.05).There were no significant difference of above parameters in routine treatment group (P>0.05). Conclusion： Ligustrazine Hydrochloride Injection is an effective drug in treatment of pneumoconiosis combined with pulmonary arterial hypertension.
【Key words】Ligustrazine Hydrochloride Injection;Coal worker’s pneumoconiosis;Pulmonary arterial hypertension ......
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