舍曲林联合丁螺环酮与舍曲林单药治疗抑郁症的对照研究(1)
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【摘要】 目的：评价舍曲林联合丁螺环酮治疗抑郁症的有效性和安全性。方法：将82例单相抑郁症患者随机分为研究组(43例，使用舍曲林联合丁螺环酮治疗)和对照组(39例，使用舍曲林单药治疗)进行为期8周的治疗，在治疗1、2、4、6、8周末使用17项汉密尔顿抑郁量表(HAMD)进行疗效评价，使用不良事件记录表及相关实验室检查评价安全性。结果：研究组完成研究42例，对照组完成研究36例，两组的总体有效率分别为73.8%和63.9%，差异无统计学意义(P=0.344)；研究组临床痊愈率(45.2%)高于对照组(22.2%)，差异有统计学意义(P=0.027)；研究组在第1、2、4周末HAMD减分率显著高于对照组，差异有统计学意义(P<0.05)。两组不良反应总体发生率分别为40.5%和38.9 %，差异无统计学意义(P=0.886)。结论：相对于单用舍曲林，舍曲林联合丁螺环酮治疗抑郁症起效较快，具有较高的治愈率。
【关键词】 抑郁症； 舍曲林； 丁螺环酮
Comparative Study on Sertraline Combined with Buspirone and Sertraline Monotherapy in Treatment of Depression/YAN Gui-ping， ZHU Zhi-wu， DING Han-chun.//Medical Innovation of China，2012，9(12)：010-012
【Abstract】 Objective： To evaluate the efficiency and safety of sertraline in combination with buspirone in the treatment of unipolar depression. Methods： 82 patients who met CCMD-3 criteria of depressive episode were randomly divided into study group(43 cases treated with sertraline in combination with buspirone) and control group(39 cases treated with sertraline monotherapy) for an eight-week treatment. The Hamilton Depression Scale-17 items(HAMD-17) was used to evaluate the efficacy at baseline and at the 1st， 2nd， 4th， 6th， and 8th weekend of the treatment. Adverse event rating scale and related laboratory examinations were employed to assess safety of the treatment. Results： 42 cases in the study group and 36 cases in the control group completed the study. There was no significant difference in effective rate between the two groups(P=0.344). However， the recovery rate in study group was significantly higher than that in control group(P=0.027). The reduction rate of score of HAMD-17 in study group at the 1st， 2nd， 4th weekend were significantly higher than those in the control group(P<0.05). Most side effects could be well tolerated， and there was no significant difference in the prevalence of side effects between the two groups(P=0.8384). The incidence rate of side effects in study group and control group was 40.5% and 38.9% respectively ......
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