SIRT1、p53在卵巢浆液性肿瘤中的表达及意义(1)
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【摘要】 目的：探讨SIRT1、p53蛋白在卵巢浆液性肿瘤中的表达，分析其在卵巢浆液性癌发生发展中的作用。方法：应用Envision二步免疫组织化学方法检测SIRT1、p53在41例卵巢浆液性囊腺癌，26例卵巢交界性浆液性囊腺瘤，28例卵巢浆液性囊腺瘤中的表达。结果：(1)SIRT1、p53在卵巢浆液性囊腺癌，卵巢交界性浆液性囊腺瘤，卵巢浆液性囊腺瘤中阳性表达差异有统计学意义(P<0.05)；(2)SIRT1在卵巢浆液性囊腺癌低分化组的表达高于高分化组，在淋巴结阳性组的表达明显高于淋巴结阴性组(P<0.05)。(3)SIRT1与p53无明显相关性。结论：SIRT1在卵巢浆液性癌中高表达。且在病理高级别及淋巴结阳性组的患者中的表达较高，提示SIRT1在肿瘤的发生发展中起到了促进作用。
【关键词】 组蛋白去乙酰化酶SIRT1； p53； 卵巢浆液性癌
Expression and significance of SIRT1、p53 in serous ovarian tumors/DU Guo-qing，ZHANG Wei./Medical Innovation of China，2012，9(13):008-010
【Abstract】 Objective:To study the expression of SIRT1， p53 protein in serous ovarian tumors， and analyze its role in the development of ovarian serous carcinoma.Methods:Envision immunohistological method were adopted to examine the expression of SIRT1， p53 and compared between the ovarian serous adenocarcinoma(n=41)， and the borderline ovarian serous cystadenoma(n=26)，and the ovarian serous cystadenoma(n=28). Results:(1)The positive rates of SIRT1、p53 were in the ovarian serous adenocarcinoma， the borderline ovarian serous cystadenoma， the ovarian serous cystadenoma. Compared with each group， expression of SIRT1 was significantly enhanced(P<0.05)；(2)the positive expression rate of SIRT1 in ovarian serous adenocarcinoma poorly-differentiated group was higher than Well-differentiated groups， expression was statistically significant， expression in node-positive group was significantly higher than the lymph node-negative group (P<0.05).(3)There was no significant correlation between SIRT1 and p53.Conclusion:SIRT1 is high expression in ovarian serous carcinoma， And higher expression in patients with pathological high-level and node-positive group， Prompt SIRT1 play a catalytic role in tumor development.
【Key words】 Silent information regulator factor SIRT1； p53； Serous ovarian carcinoma
First-author’s address: Urumqi City Maternal and Child Health Hospital，Urumqi 830054，China
doi:10.3969/j.issn.1674-4985.2012.13.000-004
卵巢癌是妇科常见肿瘤之一，其发病率在女性生殖道恶性肿瘤中仅次于宫颈癌和子宫内膜癌，但其死亡率居女性生殖道恶性肿瘤首位[1] ......
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