SELDI技术预测FOLFIRI方案治疗结肠癌疗效敏感性的应用研究(3)
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从研究结果看,应用SELDI技术可以获得预测FOLFIRI方案治疗结肠癌疗效敏感性的标识指纹,并以此预测结肠癌患者对FOLFIRI方案化疗是否敏感。若能以此为平台增加病例数,进行临床验证,建立预测FOLFIRI方案化疗疗效模型将成为可能。
参考文献
[1] Therasse P,Arbuck S G,Eisenhauer E A,et al.New guidelines to evaluate the response to treatment in solid tumors,European Organization for Reseach and Treament of Cancer,National Cancer Institute of the Unite States, National Cancer Institute of Canada[J]. J Natl Cancer Inst,2000,92(3):205-216.
[2] Fernandes L L,Martins L C,Nagashima C A,et al.CA72-4 antigen levels in serum and peritoneal washing in gastric cancer,Correlation with morphological aspects of neoplasia[J].Arq Gastroenterol,2007,44(3):235-239.
[3] 刘伟,仝林虎,苏秀兰.大肠癌综合治疗的现状及进展[J].内蒙古医学杂志,2007,3(5),124-129.
[4] 陈益定,郑树,余捷凯,等.血清蛋白质质谱模型在大肠癌诊断中的应用[J].中华肿瘤杂志,2004,2(6):417-420.
[5] Xie Li,Ma Xiao-jun,Wei Shuqing.A report on the study of the estimation of the therapeutic effect in treatment of lung cancer with gefitinib by SELDI[J].Progress in modern biomedicine,2008,8(10):1498-1500.
[6] Goldberg R M, Sargent D J.A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, doxaliplatin combinations in patients with previously untreated haetastatic coloreetal cancer[J].J Clin Oncol,2004,22(1):23-30.
(收稿日期:2012-03-08) (本文编辑:连胜利)
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