无创双水平气道正压通气联合纳洛酮治疗慢性阻塞性肺病急性加重期合并II型呼吸衰竭的疗效(1)
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【摘要】 目的：分析研究无创双水平气道正压通气联合纳洛酮治疗慢性阻塞性肺病急性加重期(AECOPD)合并II型呼吸衰竭的临床疗效。方法：治疗76例AECOPD合并II型呼吸衰竭的患者，其中常规治疗的患者38例(对照组)，采用无创双水平气道正压通气联合纳洛酮治疗的患者38例(研究组)。统计分析两组的治疗效果。结果：对照组总有效率为81.58%，研究组总有效率为94.74%，两组比较差异有统计学意义(P<0.05)。治疗后，两组患者动脉血气的pH值、PaCO2、PaO2均得到明显的改善(P<0.05)；且研究组的指标改善情况明显优于对照组(P<0.05)。结论：无创双水平气道正压通气联合纳洛酮治疗AECOPD合并II型呼吸衰竭，能够显著改善患者的血气指标，临床疗效确切，值得临床推广。
【关键词】 无创双水平气道正压通气； 纳洛酮； 慢性阻塞性肺病急性加重期； 呼吸衰竭
Curative Effect of Noninvasive Double Level Airway Positive Pressure Ventilation and Naloxone in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)and Type II Respiratory Failure/HUANG Xiao-juan,HUANG Ji-wen.//Medical Innovation of China,2012,9(14):025-026
【Abstract】 Objective:To study clinical effect of noninvasive double level airway positive pressure ventilation and Naloxone in the treatment of AECOPD and type II respiratory failure.Methods: 76 cases of AECOPD and type II respiratory failure were randomly divided into two groups (research group and control group), 38 patients in each group. The control group was treated with conventional treatment. On the basis of the treatment, the research group took Naloxone.The change of PH, PaCO2，PaO2 were tested.Results: The total effective rate of the research group was 94.74%, the total effective rate of the control group was 81.58%. The total effective rate of the two groups had significant difference(P<0.05).After treatment, pH,PaCO2, PaO2 of all patients' arterial blood gas were significantly improved(P<0.05). The index of the research group improved significantly better than that of control group(P<0.05).Conclusion:Noninvasive double level airway positive pressure ventilation and Naloxone in the treatment of AECOPD and type II respiratory failure has sure curative effect and clinical implementation should be promoted.
【Key words】 Noninvasive double level airway positive pressure ventilation; Naloxone; AECOPD; Respiratory failure
First-author’s address: Clifford Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou 511496 ......
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