294例原发性甲状腺鳞状细胞癌治疗与生存情况分析(1)
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【摘要】 目的：分析不同治疗方式对原发性甲状腺鳞状细胞癌预后的影响。方法：对在中国知网检索到的1981-2011年间报道的294例原发性甲状腺鳞状细胞癌患者，采用Kaplan-Meieri法进行Log-rank生存分布检验，比较不同治疗方式下患者的生存率。结果：原发性甲状腺鳞状细胞癌中位生存期7个月，仅有27.1%的患者行甲状腺癌根治术；手术组1年生存率低于手术加放疗组，但3年生存率手术组高于手术加放疗组，整体上放疗组生存率高于未放疗组。结论：原发性甲状腺鳞状细胞癌预后差，手术是综合治疗的基础，术后放疗有助于获得短期的生存改善。
【关键词】 甲状腺； 鳞状细胞癌； 治疗； 预后
Treatment and Survival Analysis of 294 Cases of Primary Squamous Cell Carcinoma of the Thyroid/LIU Lin，CHENG Ruo-Chuan.//Medical Innovation of China，2012，9(14)：147-149
【Abstract】 Objective：To analyze the prognosis of patients differently treated with primary squamous cell carcinoma of the thyroid.Methods：Out of 294 patients with primary squamous carcinoma of the thyroid from CNKI databases reported during 1981-2011， clinical outcome from different treatments was compared by a Kaplan-Meier analysis with Log-rank test. Results：Out of 294 patients with primary squamous carcinoma of the thyroid， the median survival was seven months. Only 27.3% of patients underwent radical thyroidectomy. The 1-year survival rate was significantly greater for patients treated in combination with surgery and radiotherapy compared with those who underwent surgery alone. But the latter group had a higher survival rate of 3-year than the former. Patients who received surgery followed by radiotherapy had a significantly longer overall survival than those without radiotherapy. Conclusion：Primary squamous cell carcinoma of the thyroid conferred an extremely poor prognosis. Surgery was the cornerstone of patient management. Postoperative radiotherapy was helpful to improve short-term survival.
【Key words】 Thyroid; Squamous cell carcinoma; Treatment; Prognosis
First-author’s address：People’s Hospital in Jianshui County of Yunnan Province， Jianshui 654300，China
doi：10.3969/j.issn.1674-4985.2012.14.100
原发性甲状腺鳞状细胞癌(primary squamous cell carcinoma of the thyroid， PSCCT)是头颈部极为罕见的肿瘤，约占甲状腺癌的1%左右[1]，是甲状腺未分化癌(anaplastic thyroid carcinoma，ATC)的一种病理类型。笔者分析了31年(1981-2011年)来国内报道的病例，研究不同治疗方式对原发性甲状腺鳞状细胞癌预后的影响，希望有助于临床实践。
1 资料与方法
1.1 一般资料 以甲状腺、鳞癌为关键词或题名 ......
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