曲美他嗪联合辛伐他汀治疗不稳定型心绞痛临床观察分析
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【摘要】目的：观察分析曲美他嗪与辛伐他汀联合治疗不稳定型心绞痛的临床效果。方法：随机把89例不稳定型心绞痛患者分为治疗组和对照组， 对照组进行常规治疗，治疗组在常规用药的基础上，联合应用曲美他嗪(20 mg，3次/d)与辛伐他汀(每晚睡前服用20 mg)，连服4周后与对照组比较治疗效果。结果：治疗组总有效率98.14%，显著高于对照组的74.28%，比较差异有统计学意义(P<0.01)。治疗组治疗后血清胆固醇、低密度脂蛋白、C反应蛋白、白细胞与治疗前相比显著下降(P<0.01)，心绞痛发作次数与持续时间与治疗前相比有明显改善(P<0.01)。结论：曲美他嗪联合辛伐他汀治疗不稳定型心绞痛，疗效满意。
【关键词】曲美他嗪；辛伐他汀；不稳定型心绞痛
Analysis of Trimetazidine Combined Simvastatin on Unstable Angina pectoris/Qi Heng-liang.//Medical Innovation of China，2012，9(16):022-023
【Abstract】Objective:To observe the effect of trimetazidine combined simvastatin on unstable angina pectoris.Methods:89 patients with unstable angina randomly allocated to the therapy group and the control group. The therapy group was given trimetazidine (20 mg，tid) and simvastatin (20 mg，qn) for 4 weeks on the basis of routine treatment. Then the clinical effect， serum lipid profile， C reactive protein and white blood cell changes were compared with the control group.Results: The treatment group total effective rate was 98.14%， significantly higher than the control group in 74.28%， had a significant difference (P<0.01). The treatment group after treatment， serum cholesterol， low density lipoprotein， C reactive protein， white cell decreased significantly (P<0.01)， angina frequency and duration are improved obviously (P<0.01). Conclusion: Combined trimetazidine and simvastatin are effective and safe in the treatment of unstable angina pectoris.
【Key words】Trimetazidine ；Simvastatin ；Unstable angina pectoris
First-author’s address:Boshan Economic Development Zone Hospital of Zibo City，Zibo 255200，China
doi:10.3969/j.issn.1674-4985.2012.16.011
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