幽门螺杆菌\端粒酶与胃癌病变的相关性研究
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【摘要】目的：研究幽门螺杆菌(Hp)感染和端粒酶活性与胃癌的相关性，为提高胃癌的早期诊断水平提供科学依据。方法：将病例根据病情分为胃癌组、萎缩性胃炎组和正常组三组，Hp感染采用快速尿素酶法、W-S染色法检测，端粒酶活性用PCR-ELISA试剂盒检测，将检测结果进行对比分析，并通过多因素Logistic回归方法作相关性分析。结果：Hp感染率对照组为30.0%，萎缩性胃炎组为44.8%，胃癌组为66.7%，胃癌组显著高于对照组和萎缩性胃炎组(P<0.05)；端粒酶活性对照组为15.0%，萎缩性胃炎组为37.9%，胃癌组为88.9%，胃癌组显著高于对照组和萎缩性胃炎组(P<0.05)，二者检出率均随胃部病变的加重而增加；多因素Logistic回归分析显示，胃癌组OR=5.78，Hp感染患者发生端粒酶活化的几率是无活化者的5.78倍(P<0.01)；萎缩性胃炎组OR=0.9，对照组OR=0.1(P>0.05)，比较差异均无统计学意义。结论：Hp感染可诱导端粒酶活化，癌症患者的端粒酶活化程度较高，二者与胃癌的发生高度相关。
【关键词】幽门螺杆菌；端粒酶；胃癌
The Related Research of Helicobacter Pylori，Telomerase and Gastric Cancer lesions/LONG Xu.//Medical Innovation of China，2012，9(16):058-059
【Abstract】Objective:To study the relationship of helicobacter pylori，telomerase，and gastric cancer lesions，and provide a scientific basis to improve the early diagnosis of gastric cancer.Methods:The cases according to the disease situation were divided into gastric cancer group，atrophic gastritis and normal groups.Hp infection was taken with rapid urease WS staining.The telomerase activity was detected by the PCR-ELISA kit.The test results were analyzed and compared，and it was taken for correlation analysis by Multivariate Logistic Regression method.Results:Hp infection in the control group was 30.0%，atrophic gastritis was 44.8%，and the gastric cancer group was 66.7%.The gastric cancer group was significantly higher than the control group and atrophic gastritis group，P<0.05.The telomerase activity in the control group was 15% ......
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