二甲双胍片治疗糖尿病前期病例的临床观察(1)
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【摘要】 目的：探究二甲双胍片治疗糖尿病前期病例的疗效及安全性。方法：将血糖高于正常值而不够糖尿病诊断标准的72例糖尿病前期患者随机分为试验组和对照组，两组均进行饮食控制和运动干预等非药物治疗措施，试验组在此基础上增加二甲双胍片的治疗，治疗6个月后比较两组患者治疗有效率及糖尿病的发生率，并观察试验组的不良反应。结果：试验组治疗有效率及糖尿病的发生率分别为91.7%、55.6%，而对照组为66.7%、27.8%，试验组有效率显著高于对照组(P<0.05)，糖尿病的发生率显著低于对照组(P<0.05)。试验组共发生2例胃肠道反应。结论：在非药物治疗的基础上增加一定剂量的二甲双胍片可以显著提高糖尿病前期病例血糖控制水平，降低糖尿病的发生率，值得临床推广应用。
【关键词】 二甲双胍； 糖尿病前期； 饮食控制
Clinical Observation of Metformin in the Treatment of Prediabetes/ ZHANG Wei.//Medical Innovation of China，2012，9(29)：034—035
【Abstract】 Objective：To explore the efficacy and security of metformin tablets in the treatment of prediabetes patients.Method：FBG and 2 h PG of 72 prediabetes patients were higher than normal value but lower than diagnostic criteria for diabetes，and they were randomly divided into experimental and control groups.Both groups were given non—drug treatment measures of diet and exercise intervention，while the experimental group was given metformin tablets in addition.Compare treatment efficiency and the incidence of diabetes between two groups after six months，and observe the adverse effects of the experimental group.Result：The treatment efficiency and the incidence of experimental group were 91.7% and 5.6%， while the control group were 66.7% and 27.8%. The treatment efficiency of experimental group was significantly higher than the control group (P<0.05)，while its diabetes incidence was significantly lower (P<0.05).There were two cases of gastrointestinal reactions in the experimental group.Conclusion：Adding metformin on the basis of non—drug treatment can significantly improve the blood glucose control level of pre—diabetes patients ......
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