顺铂+IL—2胸腔内灌注联合培美曲塞全身化疗治疗老年晚期肺腺癌恶性胸腔积液(1)
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【摘要】 目的：观察顺铂+IL-2胸腔内灌注联合培美曲塞全身化疗治疗老年晚期肺腺癌恶性胸腔积液的临床疗效及毒副反应。方法：老年肺腺癌并胸腔积液患者共51例，采用顺铂40 mg/m2及IL-2150万U胸腔灌注保留，每周一次，共2周，同时应用培美曲塞，第1天，每3周重复，完成2个周期。治疗第4周评价疗效及毒副作用。结果：51 例患者均可评价疗效，完全缓解者16例，部分缓解者25例，无效者6例，其有效率为80.39%，完全缓解率31.37%。结论：顺铂+IL-2胸腔内灌注联合培美曲塞全身化疗治疗老年晚期肺腺癌恶性胸腔积液治疗的方法疗效显著，毒性反应轻，临床使用安全。
【关键词】 顺铂； IL-2； 培美曲塞； 老年； 肺腺癌； 胸腔积液
Clinical Observation of Cisplatin + IL-2 Intrathoracic Perfusion Joint Pemetrexed Disodium Systemic Chemotherapy for Elderly Patients with Advanced Malignant Pleural Effusion of Lung Cancer/WANG Yong-ming，JING Li-jun，FENG Gui-xin，et al.//Medical Innovation of China，2012，9(31)：018-019
【Abstract】 Objective：Observation on cisplatin and IL-2 intrathoracic perfusion combined with pemetrexed disodium systemic chemotherapy for elderly patients with advanced malignant pleural effusion of lung adenocarcinoma’s clinical efficacy and side effects.Method：The lung adenocarcinoma in elderly patients with pleural effusion a total of 51 cases， the intrathoracic injection of cisplatin (40 mg/m2)and IL-2(1.5 million U)once a week for 2 weeks were given. At the same time， pemetrexed disodium for injection (500 mg/m2)， the first day， every 3 weeks repeated， two cycles. The 4th week for evaluating efficacy and side effects.Result：51 patients could be evaluated the effects， 16 cases were completely alleviated， a part of the mitigation in 25 cases， 6 cases ineffective. Then its effective rate of 80.39%， complete remission rate 31.37%.Conclusion：Cisplatin and IL-2 intrathoracic perfusion combined with pemetrexed disodium systemic chemotherapy is a effective treatment method for elderly lung adenocarcinoma patients with advanced malignant pleural effusion which were light toxicity and safe clinical use ......
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